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CDK14
Identifiers
Aliases	CDK14, PFTAIRE1, PFTK1, cyclin-dependent kinase 14, cyclin dependent kinase 14
External IDs	OMIM: 610679; MGI: 894318; HomoloGene: 7888; GeneCards: CDK14; OMA:CDK14 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	91,210,590 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	5,470,312 bp
RNA expression pattern
	Top expressed in
	postcentral gyrus; ; Region I of hippocampus proper; ; pars compacta; ; pars reticulata; ; lateral nuclear group of thalamus; ; entorhinal cortex; ; Brodmann area 10; ; superior frontal gyrus; ; Brodmann area 46; ; tendon of biceps brachii;
	Top expressed in
	cingulate gyrus; ; habenula; ; medial dorsal nucleus; ; Amygdala; ; mammillary body; ; dentate gyrus; ; lateral geniculate nucleus; ; anterior amygdaloid area; ; pontine nuclei; ; medial geniculate nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; cyclin-dependent protein serine/threonine kinase activity; kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding; cyclin binding;
Cellular component	membrane; plasma membrane; cytoplasmic cyclin-dependent protein kinase holoenzyme complex; nucleus; cytoplasm; cytosol;
Biological process	phosphorylation; regulation of canonical Wnt signaling pathway; Wnt signaling pathway; cell division; protein phosphorylation; G2/M transition of mitotic cell cycle; cell cycle; regulation of cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	5218
	18647
	ENSG00000058091
	ENSMUSG00000028926
	O94921
	O35495
	NM_001287135; NM_001287136; NM_001287137; NM_012395
	NM_011074; NM_001310448
	NP_001274064; NP_001274065; NP_001274066; NP_036527
	NP_001297377; NP_035204
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein kinase PFTAIRE-1 is an enzyme that in humans is encoded by the CDK14 gene.^[5]^[6]^[7]

Interactions

PFTK1 has been shown to interact with SEPT8.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000058091 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028926 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lazzaro MA, Albert PR, Julien JP (Jul 1997). "A novel cdc2-related protein kinase expressed in the nervous system". J Neurochem. 69 (1): 348–64. doi:10.1046/j.1471-4159.1997.69010348.x. PMID 9202329. S2CID 41686721.
^ Yang T, Chen JY (Apr 2001). "Identification and cellular localization of human PFTAIRE1". Gene. 267 (2): 165–72. doi:10.1016/S0378-1119(01)00391-2. PMID 11313143.
^ "Entrez Gene: PFTK1 PFTAIRE protein kinase 1".
^ Yang, Tao; Gao Yan-Kun; Chen Jiang-Ye (Jul 2002). "KIAA0202, a human septin family member, interacting with hPFTAIRE1". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao. 34 (4). China: 520–5. ISSN 0582-9879. PMID 12098780.