PRKD2
Protein-coding gene in the species Homo sapiens
Serine/threonine-protein kinase D2 or PKD2 is an enzyme that in humans is encoded by the PRKD2 gene .[ 5] [ 6] [ 7]
Function
The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine /threonine protein kinases, a subfamily of protein kinase C . This kinase can be activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms.[ 7]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000105287 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041187 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells" . Genome Res . 10 (10): 1546–60. doi :10.1101/gr.140200 . PMC 310934 PMID 11042152 . ^ Sturany S, Van Lint J, Muller F, Wilda M, Hameister H, Hocker M, Brey A, Gern U, Vandenheede J, Gress T, Adler G, Seufferlein T (May 2001). "Molecular cloning and characterization of the human protein kinase D2. A novel member of the protein kinase D family of serine threonine kinases" . J Biol Chem . 276 (5): 3310–8. doi :10.1074/jbc.M008719200 PMID 11062248 . ^ a b "Entrez Gene: PRKD2 protein kinase D2" .
Further reading
Sturany S, Van Lint J, Gilchrist A, et al. (2002). "Mechanism of activation of protein kinase D2(PKD2) by the CCK(B)/gastrin receptor" . J. Biol. Chem . 277 (33): 29431–6. doi :10.1074/jbc.M200934200 PMID 12058027 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Rey O, Yuan J, Rozengurt E (2003). "Intracellular redistribution of protein kinase D2 in response to G-protein-coupled receptor agonists". Biochem. Biophys. Res. Commun . 302 (4): 817–24. doi :10.1016/S0006-291X(03)00269-9 . PMID 12646243 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Yeaman C, Ayala MI, Wright JR, et al. (2004). "Protein kinase D regulates basolateral membrane protein exit from trans-Golgi network" . Nat. Cell Biol . 6 (2): 106–12. doi :10.1038/ncb1090 . PMC 3372901 PMID 14743217 . Mihailovic T, Marx M, Auer A, et al. (2005). "Protein kinase D2 mediates activation of nuclear factor kappaB by Bcr-Abl in Bcr-Abl+ human myeloid leukemia cells" . Cancer Res . 64 (24): 8939–44. doi :10.1158/0008-5472.CAN-04-0981 PMID 15604256 . Parra M, Kasler H, McKinsey TA, et al. (2005). "Protein kinase D1 phosphorylates HDAC7 and induces its nuclear export after T-cell receptor activation" . J. Biol. Chem . 280 (14): 13762–70. doi :10.1074/jbc.M413396200 PMID 15623513 . Auer A, von Blume J, Sturany S, et al. (2006). "Role of the regulatory domain of protein kinase D2 in phorbol ester binding, catalytic activity, and nucleocytoplasmic shuttling" . Mol. Biol. Cell . 16 (9): 4375–85. doi :10.1091/mbc.E05-03-0251 . PMC 1196345 PMID 15975900 . Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells". J. Proteome Res . 4 (4): 1339–46. doi :10.1021/pr050048h . PMID 16083285 . Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes" . Genome Res . 16 (1): 55–65. doi :10.1101/gr.4039406 . PMC 1356129 PMID 16344560 . Jackson LN, Li J, Chen LA, et al. (2006). "Overexpression of wild-type PKD2 leads to increased proliferation and invasion of BON endocrine cells" . Biochem. Biophys. Res. Commun . 348 (3): 945–9. doi :10.1016/j.bbrc.2006.07.142 . PMC 2430871 PMID 16899224 . Chiu TT, Leung WY, Moyer MP , et al. (2007). "Protein kinase D2 mediates lysophosphatidic acid-induced interleukin 8 production in nontransformed human colonic epithelial cells through NF-kappaB". Am. J. Physiol., Cell Physiol . 292 (2): C767–77. doi :10.1152/ajpcell.00308.2006 . PMID 16928771 . S2CID 2220790 . Irie A, Harada K, Tsukamoto H, et al. (2007). "Protein kinase D2 contributes to either IL-2 promoter regulation or induction of cell death upon TCR stimulation depending on its activity in Jurkat cells" . Int. Immunol . 18 (12): 1737–47. doi :10.1093/intimm/dxl108 PMID 17077180 . Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48. doi :10.1016/j.cell.2006.09.026 PMID 17081983 . S2CID 7827573 . Kollers S, Musilova P, Rubes J, Rocha D (2007). "Comparative mapping reveals multiple rearrangements between pig chromosome 6 and human 19q13". Anim. Genet . 37 (6): 595–6. doi :10.1111/j.1365-2052.2006.01516.x . PMID 17121608 . Wissing J, Jänsch L, Nimtz M, et al. (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry" . Mol. Cell. Proteomics . 6 (3): 537–47. doi :10.1074/mcp.T600062-MCP200 hdl :10033/19756 PMID 17192257 .
Activity Regulation Classification Kinetics Types
