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CELSR2
Identifiers
Aliases	CELSR2, CDHF10, EGFL2, Flamingo1, MEGF3, ADGRC2, cadherin EGF LAG seven-pass G-type receptor 2
External IDs	OMIM: 604265; MGI: 1858235; HomoloGene: 1078; GeneCards: CELSR2; OMA:CELSR2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	109,275,751 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	108,323,383 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; right frontal lobe; ; prefrontal cortex; ; primary visual cortex; ; hippocampus proper; ; postcentral gyrus; ; C1 segment; ; Brodmann area 9; ; superior frontal gyrus;
	Top expressed in
	superior surface of tongue; ; gallbladder; ; lip; ; subiculum; ; superior frontal gyrus; ; visual cortex; ; motor neuron; ; ascending aorta; ; primary visual cortex; ; extensor digitorum longus muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; calcium ion binding; transmembrane signaling receptor activity;
Cellular component	integral component of membrane; plasma membrane; membrane; cytoplasm;
Biological process	homophilic cell adhesion via plasma membrane adhesion molecules; regulation of transcription, DNA-templated; cell surface receptor signaling pathway; multicellular organism development; regulation of cell-cell adhesion; Wnt signaling pathway, planar cell polarity pathway; G protein-coupled receptor signaling pathway; signal transduction; neural plate anterior/posterior regionalization; Wnt signaling pathway; cell adhesion; dendrite morphogenesis; cell-cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	1952
	53883
	ENSG00000143126
	ENSMUSG00000068740
	Q9HCU4
	Q9R0M0
	NM_001408
	NM_001004177; NM_017392
	NP_001399
	NP_001004177; NP_059088
	Wikidata
View/Edit Human	View/Edit Mouse

Cadherin EGF LAG seven-pass G-type receptor 2 is a protein that in humans is encoded by the CELSR2 gene.^[5]^[6]

The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143126 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000068740 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nakayama M, Nakajima D, Nagase T, Nomura N, Seki N, Ohara O (Sep 1998). "Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening". Genomics. 51 (1): 27–34. doi:10.1006/geno.1998.5341. PMID 9693030.
^ ^a ^b "Entrez Gene: CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)".

External links

Human CELSR2 genome location and CELSR2 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000143126 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000068740 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9693030-5] Nakayama M, Nakajima D, Nagase T, Nomura N, Seki N, Ohara O (Sep 1998). "Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening". Genomics. 51 (1): 27–34. doi:10.1006/geno.1998.5341. PMID 9693030.

[entrez-6] "Entrez Gene: CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)".

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CELSR2

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