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PTAFR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2B0X
Identifiers
Aliases	PTAFR, PAFR, platelet activating factor receptor
External IDs	OMIM: 173393; MGI: 106066; HomoloGene: 20260; GeneCards: PTAFR; OMA:PTAFR - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	28,193,936 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	132,309,994 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; granulocyte; ; bone marrow; ; vena cava; ; nasal epithelium; ; pericardium; ; cecum; ; body of tongue; ; bone marrow cells;
	Top expressed in
	granulocyte; ; bone marrow; ; white adipose tissue; ; jejunum; ; esophagus; ; ileum; ; spleen; ; zone of skin; ; urinary bladder; ; muscle of thigh;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; G protein-coupled purinergic nucleotide receptor activity; lipopolysaccharide binding; signal transducer activity; mitogen-activated protein kinase binding; platelet activating factor receptor activity; phospholipid binding; lipopolysaccharide immune receptor activity; protein binding;
Cellular component	integral component of membrane; membrane; integral component of plasma membrane; plasma membrane; secretory granule membrane; tertiary granule membrane;
Biological process	G protein-coupled receptor signaling pathway; positive regulation of leukocyte tethering or rolling; inositol trisphosphate biosynthetic process; positive regulation of voltage-gated chloride channel activity; positive regulation of phospholipase C activity; negative regulation of blood pressure; interferon-gamma-mediated signaling pathway; positive regulation of inositol phosphate biosynthetic process; regulation of transcription by RNA polymerase II; positive regulation of transcytosis; cytokine production; response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine; response to symbiotic bacterium; transcytosis; positive regulation of translation; cellular response to gravity; response to dexamethasone; positive regulation of cellular extravasation; positive regulation of maternal process involved in parturition; chemotaxis; cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine; positive regulation of sensory perception of pain; response to lipopolysaccharide; cellular response to fatty acid; response to organophosphorus; birth; positive regulation of vasoconstriction; immune response; positive regulation of gastro-intestinal system smooth muscle contraction; positive regulation of tumor necrosis factor production; inflammatory response; positive regulation of smooth muscle contraction; positive regulation of neutrophil degranulation; positive regulation of leukocyte cell-cell adhesion; phosphatidylinositol-mediated signaling; lipopolysaccharide-mediated signaling pathway; cellular response to cAMP; signal transduction; positive regulation of smooth muscle cell proliferation; G protein-coupled purinergic nucleotide receptor signaling pathway; neutrophil degranulation; cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	5724
	19204
	ENSG00000169403
	ENSMUSG00000056529
	P25105
	Q62035
	NM_001164723; NM_000952; NM_001164721; NM_001164722
	NM_001081211
	NP_000943; NP_001158193; NP_001158194; NP_001158195
	NP_001074680
	Wikidata
View/Edit Human	View/Edit Mouse

The platelet-activating factor receptor (PAF-R) is a G-protein coupled receptor which binds platelet-activating factor.^[5]^[6] It is encoded in the human by the PTAFR gene.

The PAF receptor shows structural characteristics of the rhodopsin (MIM 180380) gene family and binds platelet-activating factor (PAF). PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) that has been implicated as a mediator in diverse pathologic processes, such as allergy, asthma, septic shock, arterial thrombosis, and inflammatory processes.[supplied by OMIM]^[7] Its pathogenetic role in chronic kidney failure has also been reported recently.^[8]

Ligands

Agonists

Platelet activating factor

Antagonists

Apafant (WEB-2086)
Israpafant (Y-24180)
Lexipafant
Rupatadine

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000169403 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000056529 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Seyfried CE, Schweickart VL, Godiska R, Gray PW (1992). "The human platelet-activating factor receptor gene (PTAFR) contains no introns and maps to chromosome 1". Genomics. 13 (3): 832–4. doi:10.1016/0888-7543(92)90162-L. PMID 1322356.
^ Ishii S, Nagase T, Shimizu T (2002). "Platelet-activating factor receptor". Prostaglandins Other Lipid Mediat. 68–69: 599–609. doi:10.1016/S0090-6980(02)00058-8. PMID 12432946.
^ "Entrez Gene: PTAFR platelet-activating factor receptor".
^ Correa-Costa M (Apr 2014). "Activation of platelet-activating factor receptor exacerbates renal inflammation and promotes fibrosis". Lab. Invest. 94 (4): 455–466. doi:10.1038/labinvest.2013.155. PMID 24492283.

External links

"Platelet-Activating Factor Receptor". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2007-10-25.
platelet+activating+factor+receptor at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.