LPAR5

LPAR5
Identifiers
AliasesLPAR5, GPR92, GPR93, KPG_010, LPA5, lysophosphatidic acid receptor 5
External IDsOMIM: 606926; MGI: 2685918; HomoloGene: 10696; GeneCards: LPAR5; OMA:LPAR5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

57121

381810

Ensembl

ENSG00000184574

ENSMUSG00000067714

UniProt

Q9H1C0

Q149R9

RefSeq (mRNA)

NM_020400
NM_001142961

NM_001163268
NM_001163269

RefSeq (protein)

NP_001136433
NP_065133

NP_001156740
NP_001156741

Location (UCSC)Chr 12: 6.62 – 6.64 MbChr 6: 125.04 – 125.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Lysophosphatidic acid receptor 5 also known as LPA5 is a protein that in humans is encoded by the LPAR5 gene.[5][6][7][8][9] LPA5 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).[10]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000184574 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000067714 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23". Nature Genetics. 26 (3): 345–348. November 2000. doi:10.1038/81664. PMID 11062477. S2CID 38870810.
  6. ^ Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, et al. (September 2001). "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene. 275 (1): 83–91. doi:10.1016/S0378-1119(01)00651-5. PMID 11574155.
  7. ^ Lee CW, Rivera R, Gardell S, Dubin AE, Chun J (August 2006). "GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5". The Journal of Biological Chemistry. 281 (33): 23589–23597. doi:10.1074/jbc.M603670200. PMID 16774927.
  8. ^ Kotarsky K, Boketoft A, Bristulf J, Nilsson NE, Norberg A, Hansson S, et al. (August 2006). "Lysophosphatidic acid binds to and activates GPR92, a G protein-coupled receptor highly expressed in gastrointestinal lymphocytes". The Journal of Pharmacology and Experimental Therapeutics. 318 (2): 619–628. doi:10.1124/jpet.105.098848. PMID 16651401. S2CID 5989815.
  9. ^ "Entrez Gene: GPR92 G protein-coupled receptor 92".
  10. ^ Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, et al. (January 2010). "LPA receptors: subtypes and biological actions". Annual Review of Pharmacology and Toxicology. 50 (1): 157–186. doi:10.1146/annurev.pharmtox.010909.105753. PMID 20055701.

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