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GPBAR1
Identifiers
Aliases	GPBAR1, BG37, GPCR19, GPR131, M-BAR, TGR5, G protein-coupled bile acid receptor, G protein-coupled bile acid receptor 1
External IDs	OMIM: 610147; MGI: 2653863; HomoloGene: 18125; GeneCards: GPBAR1; OMA:GPBAR1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	218,263,861 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	74,318,783 bp
RNA expression pattern
	Top expressed in
	testicle; ; monocyte; ; granulocyte; ; decidua; ; gallbladder; ; blood; ; subcutaneous adipose tissue; ; apex of heart; ; spleen; ; gastric mucosa;
	Top expressed in
	blastocyst; ; embryo; ; embryo; ; yolk sac; ; urinary bladder; ; placenta; ; intestine; ; ileum; ; zygote; ; duodenum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	bile acid receptor activity; G protein-coupled receptor activity; G protein-coupled bile acid receptor activity; signal transducer activity;
Cellular component	cytoplasm; integral component of membrane; plasma membrane; membrane;
Biological process	signal transduction; cell surface bile acid receptor signaling pathway; regulation of bicellular tight junction assembly; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	151306
	227289
	ENSG00000179921
	ENSMUSG00000064272
	Q8TDU6
	Q80SS6
	NM_001077191; NM_001077194; NM_170699; NM_001321950
	NM_174985
	NP_001070659; NP_001070662; NP_001308879; NP_733800
	NP_778150
	Wikidata
View/Edit Human	View/Edit Mouse

The G protein-coupled bile acid receptor 1 (GPBAR1) also known as G-protein coupled receptor 19 (GPCR19), membrane-type receptor for bile acids (M-BAR) or Takeda G protein-coupled receptor 5 (TGR5) is a protein that in humans is encoded by the GPBAR1 gene.^[5]^[6]

Function

This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This protein functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids.^[7]

One effect of this receptor is to activate deiodinases which convert the prohormone thyroxine (T₄) to the active hormone triiodothyronine (T₃). T₃ in turn activates the thyroid hormone receptor which increases metabolic rate.^[8]^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000179921 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000064272 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kawamata Y, Fujii R, Hosoya M, Harada M, Yoshida H, Miwa M, Fukusumi S, Habata Y, Itoh T, Shintani Y, Hinuma S, Fujisawa Y, Fujino M (2003). "A G protein-coupled receptor responsive to bile acids". J. Biol. Chem. 278 (11): 9435–40. doi:10.1074/jbc.M209706200. PMID 12524422.
^ Wang H, Tan YZ, Mu RH, Tang SS, Liu X, Xing SY, Long Y, Yuan DH, Hong H (June 2021). "Takeda G Protein-Coupled Receptor 5 Modulates Depression-like Behaviors via Hippocampal CA3 Pyramidal Neurons Afferent to Dorsolateral Septum". Biological Psychiatry. 89 (11): 1084–1095. doi:10.1016/j.biopsych.2020.11.018. PMID 33536132. S2CID 227165118.
^ "Entrez Gene: GPBAR1 G protein-coupled bile acid receptor 1".
^ Watanabe M, Houten SM, Mataki C, Christoffolete MA, Kim BW, Sato H, Messaddeq N, Harney JW, Ezaki O, Kodama T, Schoonjans K, Bianco AC, Auwerx J (2006). "Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation". Nature. 439 (7075): 484–9. Bibcode:2006Natur.439..484W. doi:10.1038/nature04330. PMID 16400329. S2CID 4429032.
^ Baxter JD, Webb P (2006). "Metabolism: bile acids heat things up". Nature. 439 (7075): 402–3. Bibcode:2006Natur.439..402B. doi:10.1038/439402a. PMID 16437098. S2CID 45562883.

External links

"Bile Acid Receptor". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2007-11-01.
GPBAR1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000179921 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000064272 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12524422-5] Kawamata Y, Fujii R, Hosoya M, Harada M, Yoshida H, Miwa M, Fukusumi S, Habata Y, Itoh T, Shintani Y, Hinuma S, Fujisawa Y, Fujino M (2003). "A G protein-coupled receptor responsive to bile acids". J. Biol. Chem. 278 (11): 9435–40. doi:10.1074/jbc.M209706200. PMID 12524422.

[pmid33536132-6] Wang H, Tan YZ, Mu RH, Tang SS, Liu X, Xing SY, Long Y, Yuan DH, Hong H (June 2021). "Takeda G Protein-Coupled Receptor 5 Modulates Depression-like Behaviors via Hippocampal CA3 Pyramidal Neurons Afferent to Dorsolateral Septum". Biological Psychiatry. 89 (11): 1084–1095. doi:10.1016/j.biopsych.2020.11.018. PMID 33536132. S2CID 227165118.

[entrez-7] "Entrez Gene: GPBAR1 G protein-coupled bile acid receptor 1".

[pmid16400329-8] Watanabe M, Houten SM, Mataki C, Christoffolete MA, Kim BW, Sato H, Messaddeq N, Harney JW, Ezaki O, Kodama T, Schoonjans K, Bianco AC, Auwerx J (2006). "Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation". Nature. 439 (7075): 484–9. Bibcode:2006Natur.439..484W. doi:10.1038/nature04330. PMID 16400329. S2CID 4429032.

[pmid16437098-9] Baxter JD, Webb P (2006). "Metabolism: bile acids heat things up". Nature. 439 (7075): 402–3. Bibcode:2006Natur.439..402B. doi:10.1038/439402a. PMID 16437098. S2CID 45562883.

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G protein-coupled bile acid receptor

Function

References

Further reading

External links