5-APB (abbreviation of "5-(2-aminopropyl)benzofuran"; see infobox for the correct IUPAC name) is an empathogenic psychoactive compound of the substituted benzofuran, substituted amphetamine and substituted phenethylamine classes. 5-APB and other compounds are sometimes informally called "Benzofury".
5-APB is commonly found as the succinate and hydrochloride salt. The hydrochloride salt is 10% more potent by mass and doses should be adjusted accordingly.
5-APB has been sold as a designer drug since 2010.[2]
5-APB is a serotonin–norepinephrine–dopamine reuptake inhibitor with Ki(NET)=180 nmol/L, Ki(DAT)=265 nmol/L and Ki(SERT)=811 nmol/L.[3] It is also a serotonin–norepinephrine–dopamine releasing agent.[4] 5-APB is a potent agonist for the 5-HT2A and 5-HT2B receptors (Ki of 14 nmol/L at 5-HT2B with an efficacy of[3] 0.924). This agonism for 5-HT2B makes it likely that 5-APB would be cardiotoxic with long term use, as seen in other 5-HT2B agonists such as fenfluramine and MDMA. [citation needed] 5-APB is also an agonist of the 5-HT2C receptor.[5]
A forensic standard of 5-APB is available, and the compound has been posted on the Forendex website of potential drugs of abuse.[6] The US Department of Justice and DEA have also conducted studies concerning the detection of 5-APB.[7]
Users describe effects as euphoric. Largely, effects reported were similar to that of the drug MDMA but not as strong.[citation needed] Recreational use of 5-APB has been associated with death in combination with other drugs[8][9] and solely as the result of 5-APB.[10]
On March 5, 2014 the UK Home Office announced that 5-APB would be made a class B drug on 10 June 2014 alongside every other benzofuran entactogen and many structurally related drugs.[11]
5-APB ... has been implicated in 10 recent drug-related deaths in the UK
Stimulants: Phenylethanolamine
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