STS-135 (N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide, also called 5F-APICA) is a designer drug offered by online vendors as a cannabimimetic agent. The structure of STS-135 appears to use an understanding of structure-activity relationships within the indole class of cannabimimetics, although its design origins are unclear.[1] STS-135 is the terminally-fluorinated analogue of SDB-001, just as AM-2201 is the terminally-fluorinated analogue of JWH-018, and XLR-11 is the terminally-fluorinated analogue of UR-144. STS-135 acts a potent cannabinoid receptor agonist in vitro, with an EC50 of 51 nM for human CB2 receptors, and 13 nM for human CB1 receptors.[2] STS-135 produces bradycardia and hypothermia in rats at doses of 1–10 mg/kg, suggesting cannabinoid-like activity.[2]
As of October 2015 STS-135 is a controlled substance in China.[3] It is also illegal in the UK.
A forensic standard of STS-135 is available, and the compound has been posted on the Forendex website of potential drugs of abuse.[4]
This cannabinoid related article is a stub. You can help Wikipedia by expanding it.
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هذه المقالة يتيمة إذ تصل إليها مقالات أخرى قليلة جدًا. فضلًا، ساعد بإضافة وصلة إليها في مقالات متعلقة بها. (أبريل 2019) جوزيف دفي معلومات شخصية الميلاد 3 فبراير 1934 (89 سنة) دبلن مواطنة أيرلندا مناصب مطران في المنصب7 يوليو 1979 – 6 مايو 2010 أسقف كلوغر تولى المنص…
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