JWH-098

JWH-098

Legal status
Legal status	BR: Class F2 (Prohibited psychotropics)[1] CA: Schedule II DE: NpSG (Industrial and scientific use only) UK: Class B US: Schedule I
Identifiers
IUPAC name 4-Methoxynaphthalen-1-yl-(1-pentyl-2-methylindol-3-yl)methanone
CAS Number	316189-74-9
PubChem CID	45272116
ChemSpider	24628229
UNII	T27V33219F
CompTox Dashboard (EPA)	DTXSID80185501
Chemical and physical data
Formula	C26H27NO2
Molar mass	385.507 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCCCCn(c1C)c2ccccc2c1C(=O)c(ccc3OC)c4ccccc34
InChI InChI=1S/C26H27NO2/c1-4-5-10-17-27-18(2)25(22-13-8-9-14-23(22)27)26(28)21-15-16-24(29-3)20-12-7-6-11-19(20)21/h6-9,11-16H,4-5,10,17H2,1-3H3 Key:CNTCHEBQQFICNR-UHFFFAOYSA-N
(verify)

JWH-098 is a synthetic cannabinoid receptor agonist from the naphthoylindole family. It is the indole 2-methyl derivative of a closely related compound JWH-081, but has markedly different affinity for the CB₁ and CB₂ receptors. While JWH-081 is around tenfold selective for CB₁ over CB₂, in JWH-098 this is reversed, and it is around four times weaker than JWH-081 at CB₁ while being six times more potent at CB₂, giving it a slight selectivity for CB₂ overall. This makes JWH-098 a good example of how methylation of the indole 2-position in the naphthoylindole series tends to increase CB₂ affinity, but often at the expense of CB₁ binding.^[2]

In the United States, all CB₁ receptor agonists of the 3-(1-naphthoyl)indole class such as JWH-098 are Schedule I Controlled Substances.^[3]

JWH-098 is illegal in Russia,^[4] Sweden,^[5] and the UK,^[6] although it is unclear whether it has any history of human use.

• JWH-007
• JWH-081

This cannabinoid related article is a stub. You can help Wikipedia by expanding it.

• v
• t
• e