Nonabine

Nonabine
Clinical data
ATC code
  • none
Legal status
Legal status
  • Not approved for any medical use
Identifiers
  • 7-(1,2-Dimethylheptyl)-2,2-dimethyl-4-(4-pyridinyl)-2H-1-benzopyran-5-ol
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC25H33NO2
Molar mass379.544 g·mol−1
3D model (JSmol)
  • CCCCCC(C)C(C)c1cc(c2c(c1)OC(C=C2c3ccncc3)(C)C)O
  • InChI=1S/C25H33NO2/c1-6-7-8-9-17(2)18(3)20-14-22(27)24-21(19-10-12-26-13-11-19)16-25(4,5)28-23(24)15-20/h10-18,27H,6-9H2,1-5H3 ☒N
  • Key:YHUDSHIRWOVVCV-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Nonabine (BRL-4664) is an experimental drug which is a synthetic THC analog.[1] It was studied in the 1980s for the prevention of nausea and vomiting associated with cancer chemotherapy but was never marketed.[1] It has strong antiemetic effects equivalent to those of chlorpromazine, and also produces some mild sedative effects, along with dry mouth and EEG changes typical of cannabinoid agonists, but with minimal changes in mood or perception, suggesting the abuse potential is likely to be low.[2][3]

References

  1. ^ a b Staquet M, Bron D, Rozencweig M, Kenis Y (1981). "Clinical studies with a THC analog (BRL-4664) in the prevention of cisplatin-induced vomiting". Journal of Clinical Pharmacology. 21 (S1): 60S – 63S. doi:10.1002/j.1552-4604.1981.tb02575.x. PMID 7197692. S2CID 30609591.
  2. ^ Archer CB, Amlot PL, Trounce JR (January 1983). "Antiemetic effect of nonabine in cancer chemotherapy: a double blind study comparing nonabine and chlorpromazine". British Medical Journal. 286 (6362): 350–1. doi:10.1136/bmj.286.6362.350-a. PMC 1546960. PMID 6402096.
  3. ^ McClelland GR, Sutton JA (1985). "Pilot investigation of the quantitative EEG and clinical effects of ketazolam and the novel antiemetic nonabine in normal subjects". Psychopharmacology. 85 (3): 306–8. doi:10.1007/BF00428192. PMID 2860687. S2CID 19560039.
Stub icon

This drug article relating to the gastrointestinal system is a stub. You can help Wikipedia by expanding it.

Stub icon

This cannabinoid related article is a stub. You can help Wikipedia by expanding it.

Read other articles:

Chanson pour boire

An 18th century chanson pour boire Chanson pour boire and chanson à boire are terms for French drinking songs, frequently coupled with chanson pour danser (or song for dancing). It was used in from about 1627–1670. It is different from the air à boire primarily by the period the term was used, and that chansons pour boire are usually for one voice with lute accompaniment, and airs à boire are for multiple voices with lute accompaniment. Both are fairly simple; strophic, with syllabic set...

 

 

Daftar Wali Kota Tegal

Wali Kota TegalPetahanaDadang Somantrisejak 23 Maret 2019KediamanJalan Ki Gede Sebayu 1 Kota TegalMasa jabatan5 tahunPejabat pertamaD.J. SpanjaardSitus webSitus Resmi Kota Tegal Artikel ini memuat daftar wali kota Tegal, dari masa ke masa. No Wali Kota Mulai menjabat Akhir menjabat Prd. Ket. Wakil Wali Kota 1 Dirk Johannes Spanjaard 1929 1933 1 2 J.J.Ph. Koppenol 1933 1935 2 3 A.M. Pino 1935 1937 3 4 Mr. W.A. Court 1937 1941 4 5 H. Leenmans 1941 1942 5 6 Mr. Besar Mertokoesoemo 1942 1945...

 

 

Человек прямоходящий

† Человек прямоходящий Научная классификация Домен:ЭукариотыЦарство:ЖивотныеПодцарство:ЭуметазоиБез ранга:Двусторонне-симметричныеБез ранга:ВторичноротыеТип:ХордовыеПодтип:ПозвоночныеИнфратип:ЧелюстноротыеНадкласс:ЧетвероногиеКлада:АмниотыКлада:Синапсиды�...

Metrojet Flight 9268

2015 terrorist bombing of Russian aircraft above the northern Sinai in Egypt Flight 9268 redirects here. For the Red Wings Airlines accident in 2012, see Red Wings Airlines Flight 9268. Metrojet Flight 9268EI-ETJ, the aircraft involved, seen in June 2015BombingDate31 October 2015 (2015-10-31)SummaryBombing by Islamic State's Sinai branchSiteNear Housna, North Sinai Governorate, Egypt 30°10′9″N 34°10′22″E / 30.16917°N 34.17278°E / 30.16917; 34...

 

 

Mohamed Tchité

Burundian footballer (born 1984) Mohamed Tchité Tchité after a game with Racing in 2009Personal informationFull name Mohamed Gasana TchitéDate of birth (1984-01-31) 31 January 1984 (age 40)Place of birth Bujumbura, BurundiHeight 1.76 m (5 ft 9 in)Position(s) StrikerYouth career1996–2001 AS RangersSenior career*Years Team Apps (Gls)2001–2002 Prince Louis 2002–2003 Mukura Victory 2003–2006 Standard Liège 58 (21)2006–2007 Anderlecht 33 (21)2007–2010 Racing San...

 

 

Belmore railway station

Railway station in Sydney, New South Wales, Australia BelmoreStation building and entrance, October 2022General informationLocationBurwood Road, BelmoreCoordinates33°55′02″S 151°05′19″E / 33.91725833°S 151.0887111°E / -33.91725833; 151.0887111Elevation33 metres (108 ft)Owned byTransport Asset Holding EntityOperated bySydney TrainsLine(s)BankstownDistance13.25 km (8.23 mi) from CentralPlatforms2 (1 island)Tracks2Connections BusConstructionStru...

Elobey Grande

Questa voce sull'argomento isole della Guinea Equatoriale è solo un abbozzo. Contribuisci a migliorarla secondo le convenzioni di Wikipedia. Elobey GrandeGeografia fisicaCoordinate0°59′00″N 9°30′00″E / 0.983333°N 9.5°E0.983333; 9.5Coordinate: 0°59′00″N 9°30′00″E / 0.983333°N 9.5°E0.983333; 9.5 Geografia politicaStato Guinea Equatoriale DemografiaAbitanti0 Cartografia Elobey Grande voci di isole della Guinea Equatoriale presen...

 

 

Lists of Polish films

Cinema of Poland List of Polish films Interwar Period Pre 1930 1930s 1940s 1950s 1960s 1970s 1980s 1990s 2000s 2010s 2020svte List of films produced in the Cinema of Poland. For an A-Z list of films currently covered on Wikipedia see Polish films. Interwar List of films made in Poland in the Interwar Period 1902–1929 List of Polish films pre 1930 1930s List of Polish films of the 1930s 1940s List of Polish films of the 1940s 1950s List of Polish films of the 1950s 1960s List of Polish film...

 

 

XII legislatura del Regno d'Italia

XII legislaturaS.M. Re Vittorio Emanuele II inaugura la XII legislaturaStato Italia MonarcaVittorio Emanuele II di Savoia Inizio23 novembre 1874 Fine3 ottobre 1876 SessioniI sessione23 nov. 1874–21 feb. 1876 II sessione6 mar. 1876–3 ott. 1876 CameraElezioni8 novembre 1874 (Dettagli) PresidenteGiuseppe Biancheri DeputatiElenco SenatoPresidenteLuigi Des AmbroisGiuseppe Pasolini SenatoriElenco Capi di governoGoverniMinghetti II (1873-1876)Depretis I (1876-1877) XI legislatura XIII legis...

Kool Savas

Kool Savas (2019) Kool Savas [ˌkuːl saˈvaːʃ] (bürgerlich Savaş Yurderi; * 10. Februar 1975 in Aachen) ist ein deutscher Rapper. Seit Mitte der 1990er-Jahre ist er in der Berliner Hip-Hop-Szene aktiv. Durch die Beteiligung innerhalb der Formationen M.O.R. und Westberlin Maskulin erlangte Savas erste Bekanntheit. Seine Soloalben Der beste Tag meines Lebens, Tot oder lebendig, Aura, Märtyrer, KKS und Aghori sowie die Kollaborationsprojekte One mit Azad, Gespaltene Persönlichkeit mit Xav...

 

 

Vilnius International Film Festival

Vilnius International Film FestivalLocationVilnius, LithuaniaFounded1995LanguageLithuanian & EnglishWebsitekinopavasaris.ltThe Vilnius International Film Festival (VIFF) Kino pavasaris is a film festival held annually in March in Vilnius, Lithuania since 1995, and is the largest film festival in the nation in number of films and audience. It is one of the most anticipated annual cultural events in Lithuania. Vilnius International Film Festival Kino Pavasaris is the biggest and most import...

 

 

Chaudhary Bansi Lal University

Chaudhary Bansi Lal UniversityMottoविद्या गुरूणां गुरूः (Sanskrit)TypeState university, PostgraduateEstablished2014 (2014)ChancellorGovernor of HaryanaVice-ChancellorProf. Deepti DharmaniLocationBhiwani, Haryana, 127021, India28°47′57″N 76°08′01″E / 28.799045°N 76.133511°E / 28.799045; 76.133511LanguageEnglish & HindiWebsitehttps://cblu.ac.in/ Chaudhary Bansi Lal University (CBLU) is a state university in the ci...

Humen

Strait in Guangdong, China This article is about the strait. For the town, see Humen Town. HumenView of the Humen Bridge over the straitTraditional Chinese虎門Simplified Chinese虎门PostalHu-munLiteral meaningThe Tiger GateTranscriptionsStandard MandarinHanyu PinyinHǔménWade–GilesHu-menYue: CantoneseJyutpingFu2 mun4 The Humen, also known as the Bocca Tigris or the Bogue, is a narrow strait in the Pearl River Delta that separates Shiziyang in the north and Lingdingyang in the ...

 

 

Biyi Bandele

Nigerian writer and filmmaker (1967–2022) Biyi BandeleBandele at the Zanzibar International Film Festival, 2014BornBiyi Bandele-Thomas(1967-10-13)13 October 1967Kafanchan, Kaduna State, NigeriaDied7 August 2022(2022-08-07) (aged 54)Lagos, NigeriaAlma materObafemi Awolowo University, Ile-IfeOccupations Filmmaker novelist playwright Years active1998–2022Notable workHalf of a Yellow SunChildren2Awards1989 – International Student Playscript Competition – Rain 1994 – Londo...

 

 

George Maxwell Richards

George Maxwell Richards George Maxwell Richards en 2010 4.º Presidente de la República de Trinidad y Tobago 17 de marzo de 2003-17 de marzo de 2013Predecesor Arthur RobinsonSucesor Anthony Carmona Información personalNacimiento 1 de diciembre de 1931 San Fernando (Trinidad y Tobago, Imperio británico) Fallecimiento 8 de enero de 2018 (86 años)Puerto España (Trinidad y Tobago) Causa de muerte Insuficiencia cardíaca Nacionalidad TrinitenseLengua materna Inglés FamiliaCónyuge Jean Ramjo...

John Wolfenden, Baron Wolfenden

British educationalist This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: John Wolfenden, Baron Wolfenden – news · newspapers · books · scholar · JSTOR (October 2013) (Learn how and when to remove this message) The Right HonourableThe Lord WolfendenCBEMember of the House of LordsIncumbentAssumed office 12 J...

 

 

Expeditionary economics

Part of a series onEconomics History Outline Index Branches and classifications Applied Econometrics Heterodox International Micro / Macro Mainstream Mathematical Methodology Political JEL classification codes Concepts, theory and techniques Economic systems Economic growth Market National accounting Experimental economics Computational economics Game theory Operations research Middle income trap Industrial complex By application Agricultural Behavioral Business Cultural Democracy Demographic...

 

 

Arkadiusz Radomski

Questa voce sull'argomento calciatori polacchi è solo un abbozzo. Contribuisci a migliorarla secondo le convenzioni di Wikipedia. Segui i suggerimenti del progetto di riferimento. Arkadiusz RadomskiNazionalità Polonia Altezza177 cm Peso77 kg Calcio RuoloCentrocampista Termine carriera2012 CarrieraSquadre di club1 1993-1994 Lech Poznań2 (0)1994-1997 Veendam91 (14)1997-2005 Heerenveen216 (5)2005-2008 Austria Vienna48 (10)2008-2010 N.E.C.41 (2)2010-2012...

Filipo V de Macedonia

Para otros usos de este término, véase Filipo (desambiguación). Filipo V Filipo V de Macedonia. Rey de Macedonia 221 a. C.-179 a. C.Predecesor Antígono III DosónSucesor Perseo Información personalNacimiento 238 a. C.Pella, MacedoniaFallecimiento 179 a. C. Anfípolis (Grecia) FamiliaFamilia Dinastía antigónida Padres Demetrio II de Macedonia Criseida de Macedonia Cónyuge Policratia Pareja Policratia Hijos Perseo de MacedoniaApama IV Información profesio...

 

 

SimCity Creator (Nintendo DS)

2008 video game This article includes a list of general references, but it lacks sufficient corresponding inline citations. Please help to improve this article by introducing more precise citations. (May 2011) (Learn how and when to remove this message) 2008 video gameSimCity CreatorNorth American box artDeveloper(s)AKI CorporationPublisher(s)Electronic ArtsSeriesSimCityPlatform(s)Nintendo DSReleaseJP: March 19, 2008EU: September 19, 2008NA: September 22, 2008AU: September 25, 2008Genre(s)Cit...