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JWH-030
Legal status
Legal status	DE: unscheduled ; US: Schedule I;
Identifiers
	IUPAC name Naphthalen-1-yl-(1-pentylpyrrol-3-yl)methanone;
CAS Number	162934-73-8 ;
PubChem CID	9971539;
ChemSpider	8147131;
UNII	D3WWBII0GZ;
ChEMBL	ChEMBL71810;
CompTox Dashboard (EPA)	DTXSID10433522 ;
Chemical and physical data
Formula	C20H21NO
Molar mass	291.394 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCCCn3cc(cc3)C(=O)c1cccc2ccccc12;
	InChI InChI=1S/C20H21NO/c1-2-3-6-13-21-14-12-17(15-21)20(22)19-11-7-9-16-8-4-5-10-18(16)19/h4-5,7-12,14-15H,2-3,6,13H2,1H3; Key:VPBJQDBKZSHCPC-UHFFFAOYSA-N;
	(verify)

JWH-030 is a research chemical which is a cannabinoid receptor agonist.^[2] It has analgesic effects and is used in scientific research.^[3] It is a partial agonist at CB₁ receptors, with a K_i of 87 nM, making it roughly half the potency of THC.^[4] It was discovered and named after John W. Huffman.

In the United States, CB₁ receptor agonists of the 3-(1-naphthoyl)pyrrole class such as JWH-030 are Schedule I Controlled Substances.^[5]

References

^ "Stoffe gem. Anlagen zum BtMG". Retrieved 2024-11-23.
^ Lainton JA, Huffman JW, Martin BR, Compton DR (February 1995). "1-Alkyl-3-(1-naphthoyl) pyrroles: A new class of cannabinoid". Tetrahedron Letters. 36 (9): 1401–4. doi:10.1016/0040-4039(95)00016-6.
^ Pertwee RG, Griffin G, Lainton JA, Huffman JW (September 1995). "Pharmacological characterization of three novel cannabinoid receptor agonists in the mouse isolated vas deferens". European Journal of Pharmacology. 284 (3): 241–7. doi:10.1016/0014-2999(95)00318-f. PMID 8666005.
^ Griffin G, Atkinson PJ, Showalter VM, Martin BR, Abood ME (May 1998). "Evaluation of cannabinoid receptor agonists and antagonists using the guanosine-5'-O-(3-[35S]thio)-triphosphate binding assay in rat cerebellar membranes". The Journal of Pharmacology and Experimental Therapeutics. 285 (2): 553–60. PMID 9580597.
^ 21 U.S.C. § 812: Schedules of controlled substances