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MRPL37
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3J7Y, 3J9M
Identifiers
Aliases	MRPL37, L37mt, MRP-L2, MRP-L37, MRPL2, RPML2, mitochondrial ribosomal protein L37, L2mt
External IDs	OMIM: 611843; MGI: 1926268; HomoloGene: 9536; GeneCards: MRPL37; OMA:MRPL37 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	54,225,464 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	106,924,065 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; muscle of thigh; ; right adrenal gland; ; skin of arm; ; right adrenal cortex; ; tibialis anterior muscle; ; left ventricle; ; right lobe of liver; ; left adrenal gland; ; apex of heart;
	Top expressed in
	genital tubercle; ; tail of embryo; ; muscle of thigh; ; right kidney; ; ventricular zone; ; embryo; ; lip; ; skeletal muscle tissue; ; embryo; ; triceps brachii muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	structural constituent of ribosome; RNA binding;
Cellular component	mitochondrial inner membrane; ribosome; mitochondrial ribosome; mitochondrial large ribosomal subunit; mitochondrion;
Biological process	mitochondrial translational elongation; mitochondrial translational termination; protein biosynthesis;
	Sources:Amigo / QuickGO
Orthologs
	51253
	56280
	ENSG00000116221
	ENSMUSG00000028622
	Q9BZE1
	Q921S7
	NM_016491; NM_001330602
	NM_025500
	NP_001317531; NP_057575
	NP_079776
	Wikidata
View/Edit Human	View/Edit Mouse

39S ribosomal protein L37, mitochondrial is a protein that in humans is encoded by the MRPL37 gene.^[5]^[6]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000116221 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028622 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Graack HR, Bryant ML, O'Brien TW (Jan 2000). "Identification of mammalian mitochondrial ribosomal proteins (MRPs) by N-terminal sequencing of purified bovine MRPs and comparison to data bank sequences: the large subribosomal particle". Biochemistry. 38 (50): 16569–77. doi:10.1021/bi991543s. PMID 10600119.
^ ^a ^b "Entrez Gene: MRPL37 mitochondrial ribosomal protein L37".