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MRPL15
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3J7Y, 3J9M
Identifiers
Aliases	MRPL15, L15mt, MRP-L15, MRP-L7, RPML7, HSPC145, mitochondrial ribosomal protein L15
External IDs	OMIM: 611828; MGI: 1351639; HomoloGene: 32210; GeneCards: MRPL15; OMA:MRPL15 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	54,148,514 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	4,855,962 bp
RNA expression pattern
	Top expressed in
	right ventricle; ; vastus lateralis muscle; ; biceps brachii; ; muscle of thigh; ; gastrocnemius muscle; ; Skeletal muscle tissue of biceps brachii; ; deltoid muscle; ; triceps brachii muscle; ; left ventricle; ; gonad;
	Top expressed in
	morula; ; sternocleidomastoid muscle; ; embryo; ; digastric muscle; ; muscle of thigh; ; temporal muscle; ; epiblast; ; extraocular muscle; ; embryo; ; blastocyst;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	structural constituent of ribosome; protein binding; RNA binding;
Cellular component	mitochondrial inner membrane; large ribosomal subunit; ribosome; mitochondrion; mitochondrial large ribosomal subunit;
Biological process	mitochondrial translational elongation; mitochondrial translational termination; protein biosynthesis; cellular response to leukemia inhibitory factor;
	Sources:Amigo / QuickGO
Orthologs
	29088
	27395
	ENSG00000137547
	ENSMUSG00000033845
	Q9P015
	Q9CPR5
	NM_014175
	NM_001177658; NM_025300
	NP_054894
	NP_001171129; NP_079576
	Wikidata
View/Edit Human	View/Edit Mouse

39S ribosomal protein L15, mitochondrial is a protein that in humans is encoded by the MRPL15 gene.^[5]^[6]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the EcoL15 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 15q.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000137547 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033845 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kenmochi N, Suzuki T, Uechi T, Magoori M, Kuniba M, Higa S, Watanabe K, Tanaka T (Sep 2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
^ ^a ^b "Entrez Gene: MRPL15 mitochondrial ribosomal protein L15".