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RPS13
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4UG0, 4V6X, 5A2Q, 5AJ0, 4KZY, 3J7R, 4D61, 4KZX, 4D5L, 5FLX, 4UJD, 3J7P, 4KZZ, 4UJE, 4UJC
Identifiers
Aliases	RPS13, S13, ribosomal protein S13
External IDs	OMIM: 180476; MGI: 1915302; HomoloGene: 128182; GeneCards: RPS13; OMA:RPS13 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	17,077,715 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	115,933,430 bp
RNA expression pattern
	Top expressed in
	monocyte; ; ganglionic eminence; ; lymph node; ; left ovary; ; right ovary; ; canal of the cervix; ; gonad; ; gallbladder; ; uterine tube; ; endometrium;
	Top expressed in
	epiblast; ; embryo; ; embryo; ; lens; ; ventricular zone; ; spleen; ; ganglionic eminence; ; thymus; ; primary oocyte; ; neural tube;
	More reference expression data
	n/a
Gene ontology
Molecular function	small ribosomal subunit rRNA binding; structural constituent of ribosome; protein binding; mRNA binding; 5.8S rRNA binding; RNA binding; mRNA 5'-UTR binding;
Cellular component	cytosol; ribosome; membrane; focal adhesion; intracellular anatomical structure; cytosolic small ribosomal subunit; nucleolus; extracellular exosome; nucleus; nucleoplasm; extracellular matrix; postsynaptic density;
Biological process	viral transcription; SRP-dependent cotranslational protein targeting to membrane; translational initiation; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; negative regulation of RNA splicing; protein biosynthesis; rRNA processing;
	Sources:Amigo / QuickGO
Orthologs
	6207
	68052
	ENSG00000110700
	ENSMUSG00000090862
	P62277
	P62301
	NM_001017
	NM_026533
	NP_001008
	NP_080809
	Wikidata
View/Edit Human	View/Edit Mouse

40S ribosomal protein S13 is a protein that in humans is encoded by the RPS13 gene.^[5]^[6]^[7]

Function

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S15P family of ribosomal proteins. It is located in the cytoplasm. The protein has been shown to bind to the 5.8S rRNA in rat. The gene product of the E. coli ortholog (ribosomal protein S15) functions at early steps in ribosome assembly. This gene is co-transcribed with two U14 small nucleolar RNA genes, which are located in its third and fifth introns. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[7]

Interactions

RPS13 has been shown to interact with PDCD4.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000110700 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000090862 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chadeneau C, LeMoullac B, Denis MG (Aug 1993). "Cloning and analysis of the human S13 ribosomal protein cDNA". Nucleic Acids Res. 21 (12): 2945. doi:10.1093/nar/21.12.2945. PMC 309694. PMID 8332508.
^ Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
^ ^a ^b "Entrez Gene: RPS13 ribosomal protein S13".
^ Kang MJ, Ahn HS, Lee JY, Matsuhashi S, Park WY (April 2002). "Up-regulation of PDCD4 in senescent human diploid fibroblasts". Biochem. Biophys. Res. Commun. 293 (1): 617–21. doi:10.1016/S0006-291X(02)00264-4. PMID 12054647.

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Kang MJ, Ahn HS, Lee JY, et al. (2002). "Up-regulation of PDCD4 in senescent human diploid fibroblasts". Biochem. Biophys. Res. Commun. 293 (1): 617–21. doi:10.1016/S0006-291X(02)00264-4. PMID 12054647.
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Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
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Malygin A, Parakhnevitch N, Karpova G (2005). "Human ribosomal protein S13: cloning, expression, refolding, and structural stability". Biochim. Biophys. Acta. 1747 (1): 93–7. doi:10.1016/j.bbapap.2004.10.001. PMID 15680243.
Yu Y, Ji H, Doudna JA, Leary JA (2005). "Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes". Protein Sci. 14 (6): 1438–46. doi:10.1110/ps.041293005. PMC 2253395. PMID 15883184.
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