40S ribosomal protein S12

RPS12
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRPS12, S12, ribosomal protein S12
External IDsOMIM: 603660; MGI: 98105; HomoloGene: 110750; GeneCards: RPS12; OMA:RPS12 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

6206

20042

Ensembl

ENSG00000112306

ENSMUSG00000061983

UniProt

P25398

P63323
Q6ZWZ6

RefSeq (mRNA)

NM_001016

NM_011295

RefSeq (protein)

NP_001007

NP_035425

Location (UCSC)Chr 6: 132.81 – 132.82 MbChr 10: 23.66 – 23.66 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

40S ribosomal protein S12 is a protein that in humans is encoded by the RPS12 gene.[5][6][7]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S12E family of ribosomal proteins. It is located in the cytoplasm. Increased expression of this gene in colorectal cancers compared to matched normal colonic mucosa has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000112306 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000061983 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Herault Y, Michel D, Chatelain G, Brun G (Aug 1991). "cDNA and predicted amino acid sequences of the human ribosomal protein genes rpS12 and rpL17". Nucleic Acids Res. 19 (14): 4001. doi:10.1093/nar/19.14.4001. PMC 328500. PMID 1861993.
  6. ^ Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
  7. ^ a b "Entrez Gene: RPS12 ribosomal protein S12".

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