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RPS26
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4UG0, 4V6X, 5A2Q, 5AJ0, 5FLX, 3J7R, 4D61, 4D5L, 4UJD, 3J7P, 4UJE, 4UJC
Identifiers
Aliases	RPS26, DBA10, S26, ribosomal protein S26, eS26
External IDs	OMIM: 603701; MGI: 1351628; HomoloGene: 37420; GeneCards: RPS26; OMA:RPS26 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	56,044,697 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	128,462,616 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; left adrenal cortex; ; mucosa of transverse colon; ; gastric mucosa; ; right ovary; ; right adrenal cortex; ; right uterine tube; ; anterior pituitary; ; olfactory zone of nasal mucosa; ; left uterine tube;
	Top expressed in
	epiblast; ; urinary bladder; ; embryo; ; bone marrow; ; embryo; ; uterus; ; spleen; ; adrenal gland; ; thymus; ; lens;
	More reference expression data
	n/a
Gene ontology
Molecular function	structural constituent of ribosome; protein binding; mRNA binding; RNA binding; cadherin binding;
Cellular component	cytosol; ribosome; membrane; intracellular anatomical structure; cytosolic small ribosomal subunit; small ribosomal subunit; extracellular exosome; nucleoplasm; cytoplasm; endoplasmic reticulum; rough endoplasmic reticulum; polysomal ribosome; cytoplasmic side of rough endoplasmic reticulum membrane;
Biological process	viral transcription; SRP-dependent cotranslational protein targeting to membrane; translational initiation; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; negative regulation of RNA splicing; protein biosynthesis; rRNA processing; cytoplasmic translation;
	Sources:Amigo / QuickGO
Orthologs
	6231
	27370
	ENSG00000197728
	ENSMUSG00000025362
	P62854
	P62855
	NM_001029
	NM_013765
	NP_001020
	NP_038793
	Wikidata
View/Edit Human	View/Edit Mouse

40S ribosomal protein S26 is a protein that in humans is encoded by the RPS26 gene.^[5]^[6]^[7]

Function

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S26E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000197728 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025362 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
^ Filipenko ML, Mishin VP, Suturina IuA, Muravlev AI, Kopantsev EA, Karpova GG, Mertvetsov NP (Aug 1996). "[Mapping of the genes for ribosomal proteins S26, L19, and L32 on human chromosomes]". Bioorg Khim. 21 (11): 838–44. PMID 8670309.
^ ^a ^b "Entrez Gene: RPS26 ribosomal protein S26".

Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
Filipenko ML, Vladimirov SN, Muravlev AI, et al. (1994). "[Cloning cDNA of human S26 ribosomal protein and determination of its primary structure]". Bioorg. Khim. 20 (6): 644–9. PMID 7945460.
Vincent S, Marty L, Fort P (1993). "S26 ribosomal protein RNA: an invariant control for gene regulation experiments in eucaryotic cells and tissues". Nucleic Acids Res. 21 (6): 1498. doi:10.1093/nar/21.6.1498. PMC 309346. PMID 8464749.
Vladimirov SN, Ivanov AV, Karpova GG, et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry". Eur. J. Biochem. 239 (1): 144–9. doi:10.1111/j.1432-1033.1996.0144u.x. PMID 8706699.
Filipenko ML, Vinichenko NA, Karpova GG, et al. (1998). "Isolation, structural analysis and mapping of the functional gene of human ribosomal protein S26". Gene. 211 (2): 287–92. doi:10.1016/S0378-1119(98)00108-5. PMID 9602156.
Xu XR, Huang J, Xu ZG, et al. (2002). "Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 15089–94. doi:10.1073/pnas.241522398. PMC 64988. PMID 11752456.
Ivanov AV, Malygin AA, Karpova GG (2002). "[Ribosomal protein binding with the first intron of the human ribosomal protein S26 pre-mRNA stimulates its interaction with proteins extracted from Hela cells]". Mol. Biol. (Mosk.). 36 (3): 503–10. PMID 12068637.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ivanov AV, Malygin AA, Karpova GG (2005). "Human ribosomal protein S26 suppresses the splicing of its pre-mRNA". Biochim. Biophys. Acta. 1727 (2): 134–40. doi:10.1016/j.bbaexp.2004.12.011. PMID 15716004.
Yu Y, Ji H, Doudna JA, Leary JA (2005). "Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes". Protein Sci. 14 (6): 1438–46. doi:10.1110/ps.041293005. PMC 2253395. PMID 15883184.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Tu LC, Yan X, Hood L, Lin B (2007). "Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells" (PDF). Mol. Cell. Proteomics. 6 (4): 575–88. doi:10.1074/mcp.M600249-MCP200. PMID 17220478. S2CID 7203032.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

External links

GeneReviews/NCBI/NIH/UW entry on Diamond-Blackfan Anemia
Overview of all the structural information available in the PDB for UniProt: P62854 (40S ribosomal protein S26) at the PDBe-KB.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000197728 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025362 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9582194-5] Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.

[pmid8670309-6] Filipenko ML, Mishin VP, Suturina IuA, Muravlev AI, Kopantsev EA, Karpova GG, Mertvetsov NP (Aug 1996). "[Mapping of the genes for ribosomal proteins S26, L19, and L32 on human chromosomes]". Bioorg Khim. 21 (11): 838–44. PMID 8670309.

[entrez-7] "Entrez Gene: RPS26 ribosomal protein S26".

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40S ribosomal protein S26

Function

References

Further reading

External links