Mitochondrial ribosomal protein L22

MRPL22

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
3J7Y

Identifiers

MRPL22, L22mt, MRP-L22, MRP-L25, RPML25, HSPC158, mitochondrial ribosomal protein L22

External IDs

OMIM: 611835; MGI: 1333794; HomoloGene: 56664; GeneCards: MRPL22; OMA:MRPL22 - orthologs

Gene location (Human)

Chr.	Chromosome 5 (human)^[1]

Band	5q33.2	Start	154,941,073 bp^[1]
Band	5q33.2	End	154,969,411 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)^[2]

Band	11\|11 B1.3	Start	58,062,487 bp^[2]
Band	11\|11 B1.3	End	58,070,391 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

mucosa of transverse colon

left ventricle

right auricle

olfactory zone of nasal mucosa

islet of Langerhans

right ventricle

right adrenal gland

left testis

apex of heart

left adrenal gland

Top expressed in

morula

proximal tubule

right kidney

adrenal gland

epiblast

blastocyst

embryo

neural tube

embryo

quadriceps femoris muscle

More reference expression data


More reference expression data

Gene ontology
Molecular function	structural constituent of ribosome RNA binding
Cellular component	mitochondrial inner membrane large ribosomal subunit ribosome mitochondrion mitochondrial large ribosomal subunit
Biological process	mitochondrial translational elongation mitochondrial translational termination protein biosynthesis ribosome assembly
Sources:Amigo / QuickGO

Species

Human

Mouse


29093


216767


ENSG00000082515


ENSMUSG00000020514


Q9NWU5


Q8BU88

RefSeq (mRNA)


NM_014180 NM_001014990


NM_175001

RefSeq (protein)


NP_001014990 NP_054899


NP_778166 NP_001390902

Location (UCSC)

Chr 5: 154.94 – 154.97 Mb

Chr 11: 58.06 – 58.07 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

39S ribosomal protein L22, mitochondrial is a protein that in humans is encoded by the MRPL22 gene.^[5]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L22 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 4q. Two transcript variants encoding different isoforms have been found for this gene.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000082515 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020514 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: MRPL22 mitochondrial ribosomal protein L22".

Further reading

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Goldschmidt-Reisin S, Kitakawa M, Herfurth E, et al. (1999). "Mammalian mitochondrial ribosomal proteins. N-terminal amino acid sequencing, characterization, and identification of corresponding gene sequences". J. Biol. Chem. 273 (52): 34828–36. doi:10.1074/jbc.273.52.34828. PMID 9857009.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
Kenmochi N, Suzuki T, Uechi T, et al. (2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
Koc EC, Burkhart W, Blackburn K, et al. (2001). "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present". J. Biol. Chem. 276 (47): 43958–69. doi:10.1074/jbc.M106510200. PMID 11551941.
O'Brien TW (2002). "Evolution of a protein-rich mitochondrial ribosome: implications for human genetic disease". Gene. 286 (1): 73–9. doi:10.1016/S0378-1119(01)00808-3. PMID 11943462.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

v t e PDB gallery
2ftc: Structural Model for the Large Subunit of the Mammalian Mitochondrial Ribosome

Protein biosynthesis: translation (bacterial, archaeal, eukaryotic)

Proteins

Initiation factor

eIF1	eIF1 B SUI1 family eIF1A Y
eIF2	α kinase β γ eIF2A eIF2B 1 2 3 4 5 eIF2D
eIF3	A B C D E F G H I J K L M
eIF4	A 1 2 3 E1 2 3 G 1 2 3 B H
eIF5	EIF5 EIF5A 2 5B
eIF6	EIF6

Elongation factor

Bacterial/Mitochondrial	EF-Tu EF-Ts EF-G EF-4 EF-P TSFM GFM1 GFM2
Archaeal/Eukaryotic	a/eEF-1 A1 2 3 B P1 P2 P3 D E G a/eEF-2

Class 1
- eRF1
Class 2/RF3
- GSPT1
- GSPT2

Ribosomal Proteins

60S subunit	RPL3 RPL4 RPL5 RPL6 RPL7 RPL7A RPL8 RPL9 RPL10 RPL10A RPL10-like RPL11 RPL12 RPL13 RPL13A RPL14 RPL15 RPL17 RPL18 RPL18A RPL19 RPL21 RPL22 RPL23 RPL23A RPL24 RPL26 RPL27 RPL27A RPL28 RPL29 RPL30 RPL31 RPL32 RPL34 RPL35 RPL35A RPL36 RPL36A RPL37 RPL37A RPL38 RPL39 RPL40 RPL41 RPLP0 RPLP1 RPLP2 RRP15-like RSL24D1
40S subunit	RPSA RPS2 RPS3 RPS3A RPS4 (RPS4X, RPS4Y1, RPS4Y2) RPS5 RPS6 RPS7 RPS8 RPS9 RPS10 RPS11 RPS12 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS18 RPS19 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS27 RPS27A RPS28 RPS29 RPS30 RACK1

39S subunit	MRPL1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42
28S subunit	MRPS1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35

Other concepts

Ribosomal RNA / ribosome subunits

5S
23S

16S

5S
23S

16S

Cytoplasmic (80S)	Large (60S): 5S 5.8S 28S Small (40S): 18S
Mitochondrial (55S)	Large (28S): MT-RNR2, 16S MT-tRNA^Val Small (39S): MT-RNR1, 12S
Chloroplast (70S)	Large (50S): 5S 4.5S 23S Small (30S): 16S

Ribosomal proteins

(See article table)

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.

This protein-related article is a stub. You can help Wikipedia by expanding it.

Read other articles:

ضريح خواجة أتابك

ضريح_خواجة_أتابك

ضريح خواجة أتابكمعلومات عامةنوع المبنى ضريحالمكان كرمان[1] المنطقة الإدارية كرمان[1] البلد إيرانتعديل - تعديل مصدري - تعديل ويكي بيانات ضريح خواجة أتابك (بالفارسية: آرامگاه خواجه اتابک) هو ضريح تاريخي يعود إلى الدولة السلجوقية، ويقع في كرمان.[2] مراجع ^ أ ب Wiki Lo...

Angin pasat

Angin baratan (panah biru) dan angin pasat (panah kuning dan coklat) Angin pasat[1][2] adalah angin yang bertiup tetap sepanjang tahun dari daerah subtropis menuju ke daerah ekuator (khatulistiwa).[3] Terdiri dari Angin Pasat Timur Laut bertiup di belahan Bumi utara dan Angin Pasat Tenggara bertiup di belahan Bumi selatan. Referensi ^ Sudibyakto (2003). Anomali Iklim dan Mitigasi Kebakaran Hutan di Indonesia. Majalah Geografi Indonesia. 17 (1): 71–80. ^ Rahayu,...

Детская смертность

Детская_смертность

Карта мира по уровню смертности детей до 5 лет на 1000 живорождённых по данным ВБ в 2019 году Детская смертность (англ. under-5 mortality) — смертность детей в возрасте до 5 лет. Детская смертность в возрасте до 1 года иногда рассматривается отдельно как младенческая смертность (in...

ليونيد كوتشما

ليونيد كوتشما (بالأوكرانية: Леоні́д Дани́лович Ку́чма)‏ معلومات شخصية الميلاد 9 أغسطس 1938 (86 سنة) الإقامة دنِبرُو مواطنة الاتحاد السوفيتي أوكرانيا الزوجة ليودميلا كوتشما مناصب نائب الشعب الأوكراني عضو خلال الفترة15 مايو 1990 – 10 مايو 1994 فترة بر�...

Championnats du monde de cyclisme sur route 1962

Championnats_du_monde_de_cyclisme_sur_route_1962

Championnats du monde de cyclisme sur route 1962 Généralités Sport Cyclisme sur route Lieu(x) Salò et Brescia Date 29 août au 2 septembre 1962 Épreuves 4 Site web officiel Site officiel de l'UCI Navigation Berne 1961 Renaix 1963 modifier Jean Stablinski est devenu champion du monde. Les championnats du monde de cyclisme sur route 1962 ont eu lieu du 29 août au 2 septembre 1962 à Salò et Brescia en Italie. Le championnat du monde du contre-la-montre par équipes fait son apparition. ...

SMA Negeri 46 Jakarta

SMA_Negeri_46_Jakarta

SMA Negeri 46 JakartaInformasiDidirikan10 Januari 1977 (sebagai filial dari SMA Negeri 18 Jakarta)JenisNegeriAkreditasiAKepala SekolahAchmad Safari, S.Pd., M.Si.Ketua KomiteNonie Indrayanto, S.T.Jurusan atau peminatanMIPA dan IPSRentang kelasX, XI, XII MIPA, XII IPSKurikulumKurikulum Merdeka dan Kurikulum 2013Jumlah siswa972AlamatLokasiJalan Masjid Darussalam Kav. 23-25, Blok-A, Gandaria Utara, Kebayoran Baru, Jakarta Selatan, DKI Jakarta, IndonesiaTel./Faks.021-7246695Koordina...

Moritz Stefaner

Moritz_Stefaner

German data visualization specialist Moritz StefanerNationalityGermanOccupationComputer scientist Moritz Stefaner is a German data visualization specialist. He is notable for his work for organisations like the OECD, the World Economic Forum, Skype, dpa, and Max Planck Research Society.[1] Stefaner is a multiple winner of the Kantar Information is Beautiful awards.[2] His data visualisation work has been exhibited at Venice Biennale of Architecture and Ars Electronica.[1&#...

Commander Islands

Commander_Islands

Russian islands in the Bering Sea55°00′N 166°24′E / 55.00°N 166.40°E / 55.00; 166.40 Commander IslandsКомандо́рские острова́ (Russian)Komandorskiye ostrovaMap showing the position of the Commander Islands to the east of Kamchatka. The larger island to the west is Bering Island; the smaller island is Medny.SettlementNikolskoye55°11′51″N 165°59′51″E / 55.19750°N 165.99750°E / 55.19750; 165.99750Ethnic&...

Propranolol

Beta blocker drug Not to be confused with Propanol or Propofol. PropranololClinical dataPronunciation/proʊˈprænəˌlɑːl/ Trade namesInderal, othersAHFS/Drugs.comMonographLicense data US DailyMed: Propranolol Pregnancycategory AU: C Routes ofadministrationOral, rectal, intravenousATC codeC07AA05 (WHO) Legal statusLegal status AU: S4 (Prescription only) CA: ℞-only UK: POM (Prescription only) US: WARNING[1]Rx-only EU: Rx-only...

The Animals

Disambiguazione – Se stai cercando altri significati, vedi The Animals (disambigua). The AnimalsThe Animals Paese d'origine Regno Unito GenereRhythm and blues[1]Blues rock[2] Periodo di attività musicale1962 – 1969 EtichettaColumbiaDeccaMGMJetI.R.S.AtcoAtlanticABKCO Records Album pubblicati17 Studio11 Live2 Raccolte4 Sito ufficiale Modifica dati su Wikidata · Manuale Gli Animals sono stati una rock band britannica degli anni sessanta origina...

The Good Wife

Disambiguazione – Se stai cercando il remake sudcoreano omonimo, vedi Good Wife. The Good WifeImmagine tratta dalla sigla della serieTitolo originaleThe Good Wife PaeseStati Uniti d'America Anno2009-2016 Formatoserie TV Generegiudiziario Stagioni7 Episodi156 Durata42 min (episodio) Lingua originaleinglese Rapporto16:9 CreditiIdeatoreRobert King, Michelle King Interpreti e personaggi Julianna Margulies: Alicia Florrick Josh Charles: Will Gardner Christine Baranski: Diane Lockhart Matt Czuch...

Volkswagen Golf

Volkswagen_Golf

Small family cars manufactured by Volkswagen Not to be confused with Volkswagen Gol. Motor vehicle Volkswagen GolfVolkswagen Golf Mk8OverviewManufacturerVolkswagenProduction1974–presentBody and chassisClassCompact car/small family car (C)ChronologyPredecessorVolkswagen Beetle (first generation only, until 1998)SuccessorVolkswagen ID.3 (for e-Golf) The Volkswagen Golf (listenⓘ) is a compact car/small family car (C-segment) produced by the German automotive manufacturer Volkswagen since 197...

ヨハネス12世 (ローマ教皇)

ヨハネス12世_(ローマ教皇)

ヨハネス12世第130代ローマ教皇教皇就任 955年12月16日教皇離任 964年5月14日先代アガペトゥス2世次代レオ8世個人情報出生 937年スポレート公国（中部イタリア）スポレート死去 964年5月14日教皇領、ローマ原国籍スポレート公国親父アルベリーコ2世（スポレート公）、母アルダその他のヨハネステンプレートを表示ヨハネス12世（Ioannes XII、937年 - 964年5月14日）は、ロ...

2019 Rugby League World Cup 9s

2019_Rugby_League_World_Cup_9s

2019 (2019) World Cup 9s ()Number of teams12 (men), 4 (women)Host country AustraliaWinner Australia (1st title)Matches played28Points scored973 (34.75 per match)Tries scored184 (6.57 per match)Top scorer Jamayne Isaako (52 - men) Tiana Penitani (20 - women)Top try scorer Jamayne Isaako (7 - men) Tiana Penitani (5 - women)Tournaments2023 > The 2019 Rugby League World Cup 9s was the first staging of the Rugby League World Cup 9s tournament and took place...

زالبوا

هذه المقالة يتيمة إذ تصل إليها مقالات أخرى قليلة جدًا. فضلًا، ساعد بإضافة وصلة إليها في مقالات متعلقة بها. (فبراير 2022) زالبواتقسيم إداريالبلد تركيا معلومات أخرىمنطقة زمنية ت ع م+03:00 تعديل - تعديل مصدري - تعديل ويكي بيانات تظهر خريطة الإمبراطورية الحيثية «زالبا البحر الأسود» ...

USS Hampden County

USS_Hampden_County

USS Hampden County (LST-803) underway History United States NameUSS LST-803 Builder Jeffersonville Boat & Machine Company Jeffersonville, Indiana Laid down2 September 1944 Launched19 October 1944 Sponsored byMrs. Katie Bryant Commissioned13 November 1944 Decommissioned15 June 1949 Recommissioned15 November 1950 RenamedUSS Hampden County (LST-803), 1 July 1955 Decommissioned2 January 1958 Stricken17 April 1958 FateSunk as target, 26 September 1958 General characteristics Class and typeLST...

Finneset

Peninsula in Svalbard, Norway Finneset viewed from the land side Finneset is a peninsula located on the east side of Grønfjorden on Spitsbergen in Svalbard, Norway. It is located 2 kilometers (1.2 mi) south of Barentsburg. A whaling station was located there until 1905.[1] From 1911 it became the site of the first wireless station in the Arctic, named Svalbard Radio from 19 September 1925. It was also a meteorological station operated by the Norwegian Meteorological Institute. B...

تجمع شروط (رماة)

تجمع_شروط_(رماة)

تجمع شروط - قرية - تقسيم إداري البلد اليمن المحافظة محافظة حضرموت المديرية مديرية رماة العزلة عزلة رماة السكان التعداد السكاني 2004 السكان 27 • الذكور 16 • الإناث 11 • عدد الأسر 5 • عدد المساكن 5 معلومات أخرى التوقيت توقيت اليمن (+3 غرينيتش) تعديل مص...

غوشين (كنتاكي)

لمعانٍ أخرى، طالع غوشين (توضيح). غوشين الإحداثيات 38°24′06″N 85°34′58″W / 38.4017°N 85.5828°W / 38.4017; -85.5828 [1] تاريخ التأسيس 1849 تقسيم إداري البلد الولايات المتحدة[2][3] التقسيم الأعلى مقاطعة أولدهام خصائص جغرافية المساحة 517997 متر مربع0....

Baskaran Adhiban

Baskaran_Adhiban

Baskaran AdhibanBaskaran Adhiban nel 2010Nazionalità India Scacchi CategoriaGM Best ranking38º (aprile 2019) Record Miglior Elo 2701 (aprile 2019) Palmarès Olimpiadi degli scacchi BronzoTromsø 2014sq. BronzoChennai 2022sq. Campionati del Mondo Bronzoa squadre - Bursa 2010 Campionati del mondo giovanili OroCampionato del mondo under16 - Vũng Tàu 2008 Campionati Asiatici OroCampionato asiatico a squadre - Abu Dhabi 2016 ArgentoCampionato asiatico individ...