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EIF5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2E9H, 2G2K, 2IU1
Identifiers
Aliases	EIF5, EIF-5, EIF-5A, eukaryotic translation initiation factor 5, Eukaryotic initiation factor 5
External IDs	OMIM: 601710; MGI: 95309; HomoloGene: 49610; GeneCards: EIF5; OMA:EIF5 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	103,345,025 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	111,513,186 bp
RNA expression pattern
	Top expressed in
	postcentral gyrus; ; Pons; ; sperm; ; external globus pallidus; ; lateral nuclear group of thalamus; ; superior frontal gyrus; ; pars compacta; ; inferior olivary nucleus; ; superior vestibular nucleus; ; oocyte;
	Top expressed in
	otic placode; ; medullary collecting duct; ; renal corpuscle; ; saccule; ; otic vesicle; ; blood; ; human fetus; ; lacrimal gland; ; tail of embryo; ; spermatocyte;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	translation initiation factor activity; nucleotide binding; translation factor activity, RNA binding; GTP binding; GTPase activity; protein binding; eukaryotic initiation factor eIF2 binding; RNA binding; cadherin binding; GDP-dissociation inhibitor activity;
Cellular component	nucleus; plasma membrane; cytoplasm; cytosol;
Biological process	regulation of translational initiation; protein biosynthesis; activation of GTPase activity; formation of translation preinitiation complex; translational initiation; formation of cytoplasmic translation initiation complex;
	Sources:Amigo / QuickGO
Orthologs
	1983
	217869
	ENSG00000100664
	ENSMUSG00000021282
	P55010
	P59325
	NM_183004; NM_001969
	NM_173363; NM_178041
	NP_001960; NP_892116
	NP_775539; NP_829887
	Wikidata
View/Edit Human	View/Edit Mouse

Eukaryotic translation initiation factor 5 is a protein that in humans is encoded by the EIF5 gene.^[5]^[6]

EIF5 is a GTPase-activating protein.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100664 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021282 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Si K, Das K, Maitra U (Aug 1996). "Characterization of multiple mRNAs that encode mammalian translation initiation factor 5 (eIF-5)". J Biol Chem. 271 (28): 16934–8. doi:10.1074/jbc.271.28.16934. PMID 8663286.
^ "Entrez Gene: EIF5 eukaryotic translation initiation factor 5".
^ Das S, Ghosh R, Maitra U (March 2001). "Eukaryotic translation initiation factor 5 functions as a GTPase-activating protein". J. Biol. Chem. 276 (9): 6720–6. doi:10.1074/jbc.M008863200. PMID 11092890.

External links

Cap-dependent translation initiation from Nature Reviews Microbiology. A good image and overview of the function of initiation factors
PDBe-KB provides an overview of all the structure information available in the PDB for Human Eukaryotic translation initiation factor 5 (EIF5)