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GABRA6
Identifiers
Aliases	GABRA6, gamma-aminobutyric acid type A receptor alpha6 subunit, gamma-aminobutyric acid type A receptor subunit alpha6
External IDs	OMIM: 137143; MGI: 95618; HomoloGene: 20220; GeneCards: GABRA6; OMA:GABRA6 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	161,702,593 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	42,321,072 bp
RNA expression pattern
	Top expressed in
	cerebellar vermis; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; paraflocculus of cerebellum; ; pons; ; testicle; ; prefrontal cortex; ; right frontal lobe; ; Brodmann area 9; ; cingulate gyrus;
	Top expressed in
	lobe of cerebellum; ; cerebellar vermis; ; deep cerebellar nuclei; ; Epithelium of choroid plexus; ; vestibular membrane of cochlear duct; ; choroid plexus of fourth ventricle; ; inferior colliculi; ; muscle of thigh; ; medulla oblongata; ; cochlea;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	GABA-A receptor activity; ion channel activity; benzodiazepine receptor activity; chloride channel activity; extracellular ligand-gated ion channel activity; transmembrane signaling receptor activity; inhibitory extracellular ligand-gated ion channel activity; GABA-gated chloride ion channel activity; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;
Cellular component	integral component of membrane; GABA-A receptor complex; postsynaptic membrane; membrane; plasma membrane; synapse; integral component of plasma membrane; chloride channel complex; cell junction; dendrite membrane; neuron projection; postsynapse; cerebellar Golgi cell to granule cell synapse;
Biological process	gamma-aminobutyric acid signaling pathway; chloride transmembrane transport; ion transport; chloride transport; signal transduction; ion transmembrane transport; chemical synaptic transmission; regulation of membrane potential; nervous system process; synaptic transmission, GABAergic; regulation of postsynaptic membrane potential;
	Sources:Amigo / QuickGO
Orthologs
	2559
	14399
	ENSG00000145863
	ENSMUSG00000020428
	Q16445
	P16305
	NM_000811
	NM_001099641; NM_008068; NM_001359049
	NP_000802
	NP_001093111; NP_032094; NP_001345978
	Wikidata
View/Edit Human	View/Edit Mouse

Gamma-aminobutyric acid receptor subunit alpha-6 is a protein that in humans is encoded by the GABRA6 gene.^[5]^[6]

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified.^[6]

One study found a genetic variant in the gene to be associated with the personality trait neuroticism.^[7]