GABRQ

GABRQ
Identifiers
AliasesGABRQ, THETA, gamma-aminobutyric acid type A receptor theta subunit, gamma-aminobutyric acid type A receptor subunit theta
External IDsOMIM: 300349; MGI: 1888498; HomoloGene: 10233; GeneCards: GABRQ; OMA:GABRQ - orthologs
Orthologs
SpeciesHumanMouse
Entrez

55879

57249

Ensembl

ENSG00000268089

ENSMUSG00000031344

UniProt

Q9UN88

Q9JLF1

RefSeq (mRNA)

NM_018558

NM_001290435
NM_020488

RefSeq (protein)

NP_061028

NP_001277364
NP_065234

Location (UCSC)Chr X: 152.64 – 152.66 MbChr X: 71.87 – 71.89 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Gamma-aminobutyric acid receptor subunit theta is a protein that in humans is encoded by the GABRQ gene.[5][6] The protein encoded by this gene is a subunit of the GABAA receptor.

The θ subunit has highest sequence similarity with the β1 subunit.[6] This subunit coassembles with:

  • α2, β1, and γ1[6]
  • α3 and β1[7]
  • α3, β1, and ε.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000268089 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031344 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Sinkkonen ST, Hanna MC, Kirkness EF, Korpi ER (15 May 2000). "GABA(A) receptor epsilon and theta subunits display unusual structural variation between species and are enriched in the rat locus ceruleus". J. Neurosci. 20 (10): 3588–3595. doi:10.1523/jneurosci.20-10-03588.2000. PMC 6772669. PMID 10804200.
  6. ^ a b c Bonnert TP, McKernan RM, Farrar S, le Bourdellès B, Heavens RP, Smith DW, Hewson L, Rigby MR, Sirinathsinghji DJ, Brown N, Wafford KA, Whiting PJ (August 1999). "θ, a novel γ-aminobutyric acid type A receptor subunit". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9891–9896. Bibcode:1999PNAS...96.9891B. doi:10.1073/pnas.96.17.9891. PMC 22306. PMID 10449790.
  7. ^ a b Ranna M, Sinkkonen ST, Möykkynen T, Uusi-Oukari M, Korpi ER (2006). "Impact of ε and θ subunits on pharmacological properties of α3β1 GABAA receptors expressed in Xenopus oocytes". BMC Pharmacol. 6: 1. doi:10.1186/1471-2210-6-1. PMC 1363348. PMID 16412217.

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