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P2RX1
Identifiers
Aliases	P2RX1, P2X1, purinergic receptor P2X 1
External IDs	OMIM: 600845; MGI: 1098235; HomoloGene: 1921; GeneCards: P2RX1; OMA:P2RX1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	3,916,476 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	72,906,026 bp
RNA expression pattern
	Top expressed in
	popliteal artery; ; tibial arteries; ; saphenous vein; ; body of pancreas; ; monocyte; ; granulocyte; ; blood; ; right coronary artery; ; bone marrow cells; ; left coronary artery;
	Top expressed in
	detrusor urinae muscle; ; umbilical cord; ; blood; ; tunica media of zone of aorta; ; granulocyte; ; thymus; ; embryo; ; tibiofemoral joint; ; Ileal epithelium; ; perirhinal cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	zinc ion binding; purinergic nucleotide receptor activity; ion channel activity; cation channel activity; ATP binding; extracellularly ATP-gated cation channel activity; ATP-gated ion channel activity;
Cellular component	integral component of membrane; postsynaptic membrane; membrane; plasma membrane; integral component of nuclear inner membrane; integral component of plasma membrane; membrane raft; neuron projection; secretory granule membrane; specific granule membrane; external side of plasma membrane; protein-containing complex; glutamatergic synapse; integral component of postsynaptic membrane; integral component of presynaptic active zone membrane;
Biological process	response to ATP; regulation of calcium ion transport; synaptic transmission, glutamatergic; protein heterooligomerization; regulation of smooth muscle contraction; vasoconstriction; ceramide biosynthetic process; serotonin secretion by platelet; blood coagulation; ion transport; response to organic substance; cation transmembrane transport; platelet activation; regulation of blood pressure; regulation of vasoconstriction; positive regulation of ion transport; insemination; protein homooligomerization; activation of cysteine-type endopeptidase activity involved in apoptotic process; regulation of vascular associated smooth muscle contraction; neuronal action potential; signal transduction; apoptotic process; purinergic nucleotide receptor signaling pathway; neutrophil degranulation; excitatory postsynaptic potential; regulation of presynaptic cytosolic calcium ion concentration; regulation of synaptic vesicle exocytosis; cation transport; ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	5023
	18436
	ENSG00000108405
	ENSMUSG00000020787
	P51575
	P51576
	NM_002558
	NM_008771
	NP_002549
	NP_032797
	Wikidata
View/Edit Human	View/Edit Mouse

P2X purinoceptor 1, also ATP receptor, is a protein that in humans is encoded by the P2RX1 gene.^[5]

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with relatively high calcium permeability. Expressed in smooth muscle and platelets. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle, being responsible, for example, for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. It is possible that the development of selective antagonists for this receptor may provide an effective non-hormonal male contraceptive pill.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000108405 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020787 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Valera S, Talabot F, Evans RJ, Gos A, Antonarakis SE, Morris MA, Buell GN (Nov 1996). "Characterization and chromosomal localization of a human P2X receptor from the urinary bladder". Receptors Channels. 3 (4): 283–9. PMID 8834001.
^ "Entrez Gene: P2RX1 purinergic receptor P2X, ligand-gated ion channel, 1".