GABRG1
Protein-coding gene in the species Homo sapiens
Gamma-aminobutyric acid receptor subunit gamma-1 is a protein that in humans is encoded by the GABRG1 gene .[ 5] protein encoded by this gene is a subunit of the GABAA receptor .[ 6]
Variants of this gene may be associated with alcohol dependence .[ 7]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000163285 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001260 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Wilcox AS, Warrington JA, Gardiner K, Berger R, Whiting P, Altherr MR, Wasmuth JJ, Patterson D, Sikela JM (July 1992). "Human chromosomal localization of genes encoding the gamma 1 and gamma 2 subunits of the gamma-aminobutyric acid receptor indicates that members of this gene family are often clustered in the genome" . Proc. Natl. Acad. Sci. U.S.A . 89 (13): 5857–5861. Bibcode :1992PNAS...89.5857W . doi :10.1073/pnas.89.13.5857 PMC 49396 PMID 1321425 . ^ Hevers W, Lüddens H (August 1998). "The diversity of GABAA receptors. Pharmacological and electrophysiological properties of GABAA channel subtypes". Mol. Neurobiol . 18 (1): 35–86. doi :10.1007/BF02741459 . PMID 9824848 . S2CID 32359279 . ^ Ittiwut C, Listman J, Mutirangura A, Malison R, Covault J, Kranzler HR, Sughondhabirom A, Thavichachart N, Gelernter J (January 2008). "Interpopulation linkage disequilibrium patterns of GABRA2 and GABRG1 genes at the GABA cluster locus on human chromosome 4" . Genomics . 91 (1): 61–69. doi :10.1016/j.ygeno.2007.08.007 . PMC 2709929 PMID 17976953 .
Further reading
Nymann-Andersen J, Wang H, Chen L, et al. (2002). "Subunit specificity and interaction domain between GABA(A) receptor-associated protein (GABARAP) and GABA(A) receptors". J. Neurochem . 80 (5): 815–823. doi :10.1046/j.0022-3042.2002.00762.x . PMID 11948245 . S2CID 38049055 . Iwakiri M, Mizukami K, Ikonomovic MD, et al. (2009). "An immunohistochemical study of GABA A receptor gamma subunits in Alzheimer's disease hippocampus: relationship to neurofibrillary tangle progression" . Neuropathology . 29 (3): 263–269. doi :10.1111/j.1440-1789.2008.00978.x . PMC 3078755 PMID 19019179 . Craddock N, Jones L, Jones IR, et al. (2010). "Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype" . Mol. Psychiatry . 15 (2): 146–153. doi :10.1038/mp.2008.66 . PMC 3967096 PMID 19078961 . Ray LA, Hutchison KE (2009). "Associations among GABRG1, level of response to alcohol, and drinking behaviors" . Alcohol. Clin. Exp. Res . 33 (8): 1382–1390. doi :10.1111/j.1530-0277.2009.00968.x . PMC 2965732 PMID 19426171 . Ittiwut C, Listman J, Mutirangura A, et al. (2008). "Interpopulation linkage disequilibrium patterns of GABRA2 and GABRG1 genes at the GABA cluster locus on human chromosome 4" . Genomics . 91 (1): 61–69. doi :10.1016/j.ygeno.2007.08.007 . PMC 2709929 PMID 17976953 . Gratacòs M, Costas J, de Cid R, et al. (2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment". Am. J. Med. Genet. B Neuropsychiatr. Genet . 150B (6): 808–816. doi :10.1002/ajmg.b.30902 . PMID 19086053 . S2CID 44524739 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–45. doi :10.1038/ng1285 PMID 14702039 . Bonnert TP, McKernan RM, Farrar S, et al. (1999). "theta, a novel gamma-aminobutyric acid type A receptor subunit" . Proc. Natl. Acad. Sci. U.S.A . 96 (17): 9891–9896. Bibcode :1999PNAS...96.9891B . doi :10.1073/pnas.96.17.9891 PMC 22306 PMID 10449790 . Guilmatre A, Dubourg C, Mosca AL, et al. (2009). "Recurrent rearrangements in synaptic and neurodevelopmental genes and shared biologic pathways in schizophrenia, autism, and mental retardation" . Arch. Gen. Psychiatry . 66 (9): 947–956. doi :10.1001/archgenpsychiatry.2009.80 . PMC 2958844 PMID 19736351 . Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–16903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Ma DQ, Whitehead PL, Menold MM, et al. (2005). "Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism" . Am. J. Hum. Genet . 77 (3): 377–388. doi :10.1086/433195 . PMC 1226204 PMID 16080114 . Covault J, Gelernter J, Jensen K, et al. (2008). "Markers in the 5'-region of GABRG1 associate to alcohol dependence and are in linkage disequilibrium with markers in the adjacent GABRA2 gene" . Neuropsychopharmacology . 33 (4): 837–848. doi :10.1038/sj.npp.1301456 . PMC 2743531 PMID 17507911 . Enoch MA, Hodgkinson CA, Yuan Q, et al. (2009). "GABRG1 and GABRA2 as independent predictors for alcoholism in two populations" . Neuropsychopharmacology . 34 (5): 1245–1254. doi :10.1038/npp.2008.171 . PMC 2656604 PMID 18818659 . Wilcox AS, Warrington JA, Gardiner K, et al. (1992). "Human chromosomal localization of genes encoding the gamma 1 and gamma 2 subunits of the gamma-aminobutyric acid receptor indicates that members of this gene family are often clustered in the genome" . Proc. Natl. Acad. Sci. U.S.A . 89 (13): 5857–5861. Bibcode :1992PNAS...89.5857W . doi :10.1073/pnas.89.13.5857 PMC 49396 PMID 1321425 .
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