Ro 19-4603

Ro 19-4603[1]
Names
IUPAC name
tert-Butyl 8-methyl-7-oxo-5-thia-1,8,12-triazatricyclo[8.3.0.02,6]trideca-2(6),3,10,12-tetraene-11-carboxylate
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
KEGG
  • InChI=1S/C15H17N3O3S/c1-15(2,3)21-14(20)11-10-7-17(4)13(19)12-9(5-6-22-12)18(10)8-16-11/h5-6,8H,7H2,1-4H3
    Key: ZIGMMUKDYCABPW-UHFFFAOYSA-N
  • CC(C)(C)OC(=O)C1=C2CN(C(=O)C3=C(N2C=N1)C=CS3)C
Properties
C15H17N3O3S
Molar mass 319.38 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Ro 19-4603 is an inverse agonist of the benzodiazepine binding site. It has effects antagonistic to those of benzodiazepines.

Chemistry

Despite acting at the benzodiazepine site, it does not possess the benzodiazepine structure. It is an Imidazothienodiazepine: a thiophene ring, an imidazole ring and a diazepine ring fused together.

Effects & Pharmacodynamics

Ro 19-4603 is an inverse agonist at the benzodiazepine binding site. Due to this, it has effects similar to other benzodiazepine inverse agonists, notably: anxiogenesis,[2] convulsions.[3]

Administration of this compound was able to decrease voluntary alcohol consumption. This was also observed in rats selected for high alcohol preference.[4] In addition to decreasing its consumption, Ro 19-4603 is able to antagonize the intoxicating effects of alcohol.[5]

References

  1. ^ "Tert-butyl 5-methyl-6-oxo-5,6-dihydro-4h-imidazo[1,5-a]thieno[2,3-f][1,4]diazepine-3-carboxylate".
  2. ^ Belzung, C.; Misslin, R.; Vogel, E. (July 1990). "Anxiogenic effects of a benzodiazepine receptor partial inverse agonist, RO 19-4603, in a light/dark choice situation". Pharmacology, Biochemistry, and Behavior. 36 (3): 593–596. doi:10.1016/0091-3057(90)90260-o. ISSN 0091-3057. PMID 2165618. S2CID 9881393.
  3. ^ Kubová, H.; Mares, P. (October 1994). "Convulsant action of a benzodiazepine receptor agonist/inverse agonist Ro 19-4603 in developing rats". Naunyn-Schmiedeberg's Archives of Pharmacology. 350 (4): 393–397. doi:10.1007/BF00178957. ISSN 0028-1298. PMID 7845475. S2CID 1751486.
  4. ^ Balakleevsky, A.; Colombo, G.; Fadda, F.; Gessa, G. L. (1990). "Ro 19-4603, a benzodiazepine receptor inverse agonist, attenuates voluntary ethanol consumption in rats selectively bred for high ethanol preference". Alcohol and Alcoholism (Oxford, Oxfordshire). 25 (5): 449–452. ISSN 0735-0414. PMID 1965120.
  5. ^ Lister, R. G.; Durcan, M. J. (1989-03-13). "Antagonism of the intoxicating effects of ethanol by the potent benzodiazepine receptor ligand Ro 19-4603". Brain Research. 482 (1): 141–144. doi:10.1016/0006-8993(89)90551-9. ISSN 0006-8993. PMID 2539880. S2CID 22770686.


Stub icon

This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it.

Read other articles:

A Girl in the River: The Price of Forgiveness

A Girl in the River: The Price of ForgivenessFilm posterSutradaraSharmeen Obaid-ChinoyProduserTina BrownPerusahaanproduksiSOC FilmsHBO Documentary FilmsDistributorHBOTanggal rilis 28 Oktober 2015 (2015-10-28) Durasi40 menitNegaraAS, PakistanBahasaInggris, Punjabi A Girl in the River: The Price of Forgiveness adalah sebuah film dokumenter tahun 2015 sutradaraan Sharmeen Obaid-Chinoy yang berkisah tentang pembunuhan kehormatan di Pakistan. Film tersebut diproduksi oleh Tina Brown dan Sheil...

 

 

2006–07 Ashes series

Cricket series2006–07 Ashes seriesPart of the English cricket team in Australia in 2006–07The logo for the 2006–07 Ashes seriesDate23 November 2006 – 5 January 2007LocationAustraliaResultAustralia won the 5-Test series 5–0Player of the seriesRicky Ponting (Aus)Compton–Miller Medal:Ricky Ponting (Aus)Teams Australia  EnglandCaptainsRicky Ponting Andrew FlintoffMost runsRicky Ponting (576)Michael Hussey (458)Matthew Hayden (413) Kevin Pietersen (490)Paul Collingwood (433)...

 

 

ISO 3166-2:DE

Entry for Germany in ISO 3166-2 ISO 3166-2:DE is the entry for Germany in ISO 3166-2, part of the ISO 3166 standard published by the International Organization for Standardization (ISO), which defines codes for the names of the principal subdivisions (e.g., provinces or states) of all countries coded in ISO 3166-1. The current version of the standard defines codes for all 16 German states, referring to them using the German words Land (singular) and Länder (plural). Each code consists of two...

Mariana and Palau Islands campaign

United States military campaign during World War II This article includes a list of general references, but it lacks sufficient corresponding inline citations. Please help to improve this article by introducing more precise citations. (September 2014) (Learn how and when to remove this template message) Mariana and Palau Islands campaignPart of the Pacific Theater of World War IIA U.S. LVT loaded with Marines approaches Tinian during the U.S. landings on that island.DateJune – November 1944...

 

 

Sub-regions of Finland

Administrative subdivisions formed in 2009 You can help expand this article with text translated from the corresponding article in Finnish. (June 2023) Click [show] for important translation instructions. Machine translation, like DeepL or Google Translate, is a useful starting point for translations, but translators must revise errors as necessary and confirm that the translation is accurate, rather than simply copy-pasting machine-translated text into the English Wikipedia. Do not tran...

 

 

Достоевский (телесериал)

У этого термина существуют и другие значения, см. Достоевский (значения). Достоевский Жанр историко-биографическая драма Режиссёр Владимир Хотиненко Сценарист Эдуард Володарский В главных ролях Евгений Миронов Чулпан Хаматова Алла Юганова Ольга Смирнова Композитор Ал�...

Державний комітет телебачення і радіомовлення України

Державний комітет телебачення і радіомовлення України (Держкомтелерадіо) Приміщення комітетуЗагальна інформаціяКраїна  УкраїнаДата створення 2003Керівне відомство Кабінет Міністрів УкраїниРічний бюджет 1 964 898 500 ₴[1]Голова Олег НаливайкоПідвідомчі ор...

 

 

哈萨克斯坦总统

此条目序言章节没有充分总结全文内容要点。 (2019年3月21日)请考虑扩充序言，清晰概述条目所有重點。请在条目的讨论页讨论此问题。 哈萨克斯坦總統哈薩克總統旗現任Қасым-Жомарт Кемелұлы Тоқаев卡瑟姆若马尔特·托卡耶夫自2019年3月20日在任任期7年首任努尔苏丹·纳扎尔巴耶夫设立1990年4月24日（哈薩克蘇維埃社會主義共和國總統） 哈萨克斯坦 哈萨克斯坦政府...

 

 

Kapal induk Jepang Chitose

Artikel ini bukan mengenai Kapal penjelajah Jepang Chitose. Chitose sebelum diubah menjadi kapal induk ringan Sejarah Kekaisaran Jepang Nama Chitose (千歳)Pasang lunas 26 November 1934Diluncurkan 29 November 1936Mulai berlayar 25 Juli 1938Reklasifikasi 15 Desember 1943 (menjadi kapal induk ringan)Diperbarui 1942 - 1944Dioperasikan kembali 1 Januari 1944Identifikasi CVL 24Nasib Tenggelam oleh gempuran B-17 dalam Pertempuran Teluk Leyte, 25 Oktober 1944.Koordinat: 19°20′N 126°20′E࿯...

Perang Dunia I

Penyuntingan Artikel oleh pengguna baru atau anonim untuk saat ini tidak diizinkan.Lihat kebijakan pelindungan dan log pelindungan untuk informasi selengkapnya. Jika Anda tidak dapat menyunting Artikel ini dan Anda ingin melakukannya, Anda dapat memohon permintaan penyuntingan, diskusikan perubahan yang ingin dilakukan di halaman pembicaraan, memohon untuk melepaskan pelindungan, masuk, atau buatlah sebuah akun. Perang Dunia ISearah jarum jam dari atas: Parit di Front Barat; tank Mark IV Brit...

 

 

Nowendoc River

River in Australia Nowendoc RiverPeel Creek[1]Nowendoc River, 2011LocationCountryAustraliaStateNew South WalesIBRANew England Tablelands, NSW North CoastDistrictNorthern Tablelands, Mid North CoastLocal government areasMid-Coast CouncilPhysical characteristicsSourceGreat Dividing Range • locationbelow the Black Sugarloaf, south of Walcha • elevation1,150 m (3,770 ft) Mouthconfluence with the Manning River • locationnear Kn...

 

 

Battle of Arras (1917)

British offensive during the First World War For other battles with the same name, see Battle of Arras (disambiguation). Battle of ArrasPart of the Western Front of the First World WarThe Battle of Arras, April 1917[image reference needed]Date9 April – 16 May 1917LocationArras, France50°17′23″N 2°46′51″E / 50.28972°N 2.78083°E / 50.28972; 2.78083Result See Analysis sectionBelligerents  British Empire  United Kingdom  Canada  Au...

Isdianto

Artikel biografi ini ditulis menyerupai resume atau daftar riwayat hidup (Curriculum Vitae). Tolong bantu perbaiki agar netral dan ensiklopedis. IsdiantoFoto sebagai Gubernur Kepulauan Riau Gubernur Kepulauan Riau ke-4Masa jabatan27 Juli 2020 – 12 Februari 2021(Pelaksana Tugas: 13 Juli 2019 – 27 Juli 2020)PendahuluNurdin BasirunPenggantiAnsar AhmadWakil Gubernur Kepulauan Riau ke-4Masa jabatan27 Maret 2018 – 13 Juli 2019GubernurNurdin BasirunPendahuluNurdin Bas...

 

 

Nassau Street (Manhattan)

Street in Manhattan, New York South end of Nassau Street; Federal Hall National Memorial is on the left, the New York Stock Exchange Building is in the distance on the right Nassau Street is in the Financial District, within the borough of Manhattan in New York City. Its southern end is at the intersection with Broad Street and Wall Street, and its northern end is at Spruce Street, at Pace University near the foot of the Brooklyn Bridge. For its entire route, Nassau Street runs one block east...

 

 

إميل رستم

إميل رستم معلومات شخصية الميلاد 27 مارس 1952 (العمر 72 سنة)[1]الأشرفية  الطول 1.80 م (5 قدم 11 بوصة) مركز اللعب لاعب وسط  الجنسية لبنان  معلومات النادي النادي الحالي الصفاء (مدرب) المسيرة الاحترافية1 سنوات فريق م. (هـ.) 1966–1988 الحكمة لكرة القدم المنتخب الوطني 1970s–1980s...

1990 United States Senate election in Iowa

1990 United States Senate election in Iowa ← 1984 November 5, 1990 1996 →   Nominee Tom Harkin Tom Tauke Party Democratic Republican Popular vote 535,975 446,869 Percentage 54.47% 45.42% County results Harkin:      50–60%      60–70%Tauke:      50–60%      60–70%      70–80% U.S. senator before election Tom Harkin Democratic El...

 

 

Cagliari Calcio 1979-1980

Voce principale: Cagliari Calcio. Cagliari CalcioStagione 1979-1980 Sport calcio Squadra Cagliari Allenatore Mario Tiddia Presidente Mariano Delogu Serie A7º posto Coppa ItaliaPrimo turno Maggiori presenzeCampionato: Corti, Piras, Selvaggi (30) Miglior marcatoreCampionato: Selvaggi (12) StadioSant'Elia Abbonati12 976[1] Maggior numero di spettatori53 304 Media spettatori30 357 1978-1979 1980-1981 Si invita a seguire il modello di voce Questa voce raccoglie le inf...

 

 

Wilkins Coast

Wilkins Coast location Wilkins Coast is that portion of the east coast of the Antarctic Peninsula between Cape Agassiz and Cape Boggs.[1] Name Wilkins Coast was named by the United States Advisory Committee on Antarctic Names (US-ACAN) for Sir Hubert Wilkins, who in a pioneer Antarctic exploratory flight on December 20, 1928, flew southward from Deception Island and crossed the Antarctic Peninsula to its east side. He continued southward to Stefansson Strait and Hearst Island, which l...

Masseret

Pour les articles homonymes, voir Masseret (homonymie). Masseret La tour de Masseret. Blason Administration Pays France Région Nouvelle-Aquitaine Département Corrèze Arrondissement Tulle Intercommunalité Communauté de communes du pays d'Uzerche Maire Mandat Bernard Roux 2020-2026 Code postal 19510 Code commune 19129 Démographie Gentilé Masserétois Populationmunicipale 658 hab. (2021 ) Densité 49 hab./km2 Géographie Coordonnées 45° 32′ 00″ nord, 1°...

 

 

東宝東和

阪急阪神東宝グループ > 東宝 > 東宝東和 東宝東和株式会社TOHO-TOWA COMPANY, LIMITED. 本社の川喜多メモリアルビル種類 株式会社本社所在地 日本〒102-8537東京都千代田区一番町18川喜多メモリアルビル 北緯35度41分19.0秒 東経139度44分31.5秒 / 北緯35.688611度 東経139.742083度 / 35.688611; 139.742083座標: 北緯35度41分19.0秒 東経139度44分31.5秒 / 北緯35...