TrkC receptor

Neurotrofno tirozinsko kinazni receptor, tip 3
	; PDB prikaz baziran na 1wwc.
Dostupne strukture
	1WWC, 3V5Q
Identifikatori
Simboli	NTRK3; TRKC; gp145(trkC)
Vanjski ID	OMIM: 191316 MGI: 97385 HomoloGene: 49183 GeneCards: NTRK3 Gene
EC broj	2.7.10.1
Ontologija gena
Molekulska funkcija	• p53 vezivanje • aktivnost transmembranske receptorske proteinske tirozinske kinaze • aktivnost neurotrofinskg receptora
Ćelijska komponenta	• citoplazma • integralna komponenta ćelijske membrane • receptorski kompleks
Biološki proces	• aktivacija MAPK dejstva • neuronska migracija • negativna regulacija proteinske fosforilacije
Pregled RNK izražavanja
	podaci
Ortolozi

edit

Receptor NT-3 faktora rasta (neurotrono tirozinsko kinazni receptor tip 3, TrkC tirozinska kinaza, Trk-C receptor) protein protein je koji je kod ljudi kodiran NTRK3 genom.^[1]

TrkC je katalitički receptor sa visokim afinitetom za neurotrofin NT-3 (neurotrofin-3). Kao takav, TrkC posreduje višestruke efekte za ovaj neurotrofatski faktor, među kojima je neuronska diferencijacija i opstanak.

TrkC receptor je deo velike familije receptorskih tirozinskih kinaza. "Tirozinske kinaze" su enzimi koji imaju sposobnost dodavanja fosfatne grupe na pojedine tirozine na ciljnim proteinima, ili "supstratima". Receptorske tirozinske kinaze su "tirozinske kinaze kojesu locirane na ćelijskim membranama, i koje se aktiviraju vezivanjem liganda za njihove ekstracelularne domene.

Reference

↑ McGregor LM, Baylin SB, Griffin CA, Hawkins AL, Nelkin BD (July 1994). „Molecular cloning of the cDNA for human TrkC (NTRK3), chromosomal assignment, and evidence for a splice variant”. Genomics 22 (2): 267–72. DOI:10.1006/geno.1994.1383. PMID 7806211.

Literatura

Lamballe F, Klein R, Barbacid M (1991). „trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3”. Cell 66 (5): 967–79. DOI:10.1016/0092-8674(91)90442-2. PMID 1653651.
Tessarollo L, Tsoulfas P, Martin-Zanca D, et al. (1993). „trkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues”. Development 118 (2): 463–75. PMID 8223273.
Klein R, Silos-Santiago I, Smeyne RJ, et al. (1994). „Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements”. Nature 368 (6468): 249–51. DOI:10.1038/368249a0. PMID 8145824.
Ip NY, Stitt TN, Tapley P, et al. (1993). „Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells”. Neuron 10 (2): 137–49. DOI:10.1016/0896-6273(93)90306-C. PMID 7679912.
Ebendal T (1992). „Function and evolution in the NGF family and its receptors.”. J. Neurosci. Res. 32 (4): 461–70. DOI:10.1002/jnr.490320402. PMID 1326636.
Guiton M, Gunn-Moore FJ, Glass DJ, et al. (1995). „Naturally occurring tyrosine kinase inserts block high affinity binding of phospholipase C gamma and Shc to TrkC and neurotrophin-3 signaling.”. J. Biol. Chem. 270 (35): 20384–90. DOI:10.1074/jbc.270.35.20384. PMID 7657612.
Shelton DL, Sutherland J, Gripp J, et al. (1995). „Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins.”. J. Neurosci. 15 (1 Pt 2): 477–91. PMID 7823156.
Pflug BR, Dionne C, Kaplan DR, et al. (1995). „Expression of a Trk high affinity nerve growth factor receptor in the human prostate.”. Endocrinology 136 (1): 262–8. DOI:10.1210/en.136.1.262. PMID 7828539.
Lamballe F, Tapley P, Barbacid M (1993). „trkC encodes multiple neurotrophin-3 receptors with distinct biological properties and substrate specificities.”. Embo J. 12 (8): 3083–94. PMC 413573. PMID 8344249.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). „A "double adaptor" method for improved shotgun library construction.”. Anal. Biochem. 236 (1): 107–13. DOI:10.1006/abio.1996.0138. PMID 8619474.
Yamamoto M, Sobue G, Yamamoto K, et al. (1997). „Expression of mRNAs for neurotrophic factors (NGF, BDNF, NT-3, and GDNF) and their receptors (p75NGFR, trkA, trkB, and trkC) in the adult human peripheral nervous system and nonneural tissues.”. Neurochem. Res. 21 (8): 929–38. DOI:10.1007/BF02532343. PMID 8895847.
Yu W, Andersson B, Worley KC, et al. (1997). „Large-scale concatenation cDNA sequencing.”. Genome Res. 7 (4): 353–8. DOI:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Valent A, Danglot G, Bernheim A (1997). „Mapping of the tyrosine kinase receptors trkA (NTRK1), trkB (NTRK2) and trkC(NTRK3) to human chromosomes 1q22, 9q22 and 15q25 by fluorescence in situ hybridization.”. Eur. J. Hum. Genet. 5 (2): 102–4. PMID 9195161.
Terenghi G, Mann D, Kopelman PG, Anand P (1997). „trkA and trkC expression is increased in human diabetic skin.”. Neurosci. Lett. 228 (1): 33–6. DOI:10.1016/S0304-3940(97)00350-9. PMID 9197281.
Knezevich SR, McFadden DE, Tao W, et al. (1998). „A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma.”. Nat. Genet. 18 (2): 184–7. DOI:10.1038/ng0298-184. PMID 9462753.
Urfer R, Tsoulfas P, O'Connell L, et al. (1998). „High resolution mapping of the binding site of TrkA for nerve growth factor and TrkC for neurotrophin-3 on the second immunoglobulin-like domain of the Trk receptors.”. J. Biol. Chem. 273 (10): 5829–40. DOI:10.1074/jbc.273.10.5829. PMID 9488719.
Hu YQ, Koo PH (1998). „Inhibition of phosphorylation of TrkB and TrkC and their signal transduction by alpha2-macroglobulin.”. J. Neurochem. 71 (1): 213–20. DOI:10.1046/j.1471-4159.1998.71010213.x. PMID 9648868.
Ichaso N, Rodriguez RE, Martin-Zanca D, Gonzalez-Sarmiento R (1998). „Genomic characterization of the human trkC gene.”. Oncogene 17 (14): 1871–5. DOI:10.1038/sj.onc.1202100. PMID 9778053.
Qian X, Riccio A, Zhang Y, Ginty DD (1999). „Identification and characterization of novel substrates of Trk receptors in developing neurons.”. Neuron 21 (5): 1017–29. DOI:10.1016/S0896-6273(00)80620-0. PMID 9856458.
Bibel M, Hoppe E, Barde YA (1999). „Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR.”. Embo J. 18 (3): 616–22. DOI:10.1093/emboj/18.3.616. PMC 1171154. PMID 9927421.
Labouyrie E, Dubus P, Groppi A, et al. (1999). „Expression of neurotrophins and their receptors in human bone marrow.”. Am. J. Pathol. 154 (2): 405–15. DOI:10.1016/s0002-9440(10)65287-x. PMC 1849993. PMID 10027399.

[pmid7806211-1] McGregor LM, Baylin SB, Griffin CA, Hawkins AL, Nelkin BD (July 1994). „Molecular cloning of the cDNA for human TrkC (NTRK3), chromosomal assignment, and evidence for a splice variant”. Genomics 22 (2): 267–72. DOI:10.1006/geno.1994.1383. PMID 7806211.

[1]

TrkC receptor

Reference

Literatura

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