5-Fluoro-AET

5-Fluoro-AET
Clinical data
Other names5-Fluoro-α-ethyltryptamine; 5-F-AET; 5F-AET; 5-Fluoro-αET; 5-F-αET; 5F-αET; PAL-545
Identifiers
  • 1-(5-fluoro-1H-indol-3-yl)butan-2-amine
CAS Number
PubChem CID
ChemSpider
ChEMBL
Chemical and physical data
FormulaC12H15FN2
Molar mass206.264 g·mol−1
3D model (JSmol)
  • CCC(CC1=CNC2=C1C=C(C=C2)F)N
  • InChI=1S/C12H15FN2/c1-2-10(14)5-8-7-15-12-4-3-9(13)6-11(8)12/h3-4,6-7,10,15H,2,5,14H2,1H3
  • Key:QGUZSMSUGSSPNJ-UHFFFAOYSA-N

5-Fluoro-AET, also known as 5-fluoro-α-ethyltryptamine or by the code name PAL-545, is a substituted tryptamine derivative which acts as a serotonin–dopamine releasing agent (SDRA) and as an agonist of the serotonin 5-HT2A receptor.[1]

Its EC50Tooltip half-maximal effective concentration values for monoamine release are 36.6 nM for serotonin, 5,334 nM for norepinephrine, and 150 nM for dopamine.[1] Its EC50 at the serotonin 5-HT2A receptor is 246 nM and its EmaxTooltip maximal efficacy at the receptor is 87%.[1]

See also

References

  1. ^ a b c Blough BE, Landavazo A, Partilla JS, Decker AM, Page KM, Baumann MH, Rothman RB (October 2014). "Alpha-ethyltryptamines as dual dopamine-serotonin releasers". Bioorganic & Medicinal Chemistry Letters. 24 (19): 4754–4758. doi:10.1016/j.bmcl.2014.07.062. PMC 4211607. PMID 25193229.



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