AGH-192

AGH-192
Identifiers
  • 3-(3-ethylimidazol-4-yl)-4-fluoro-5-iodo-1H-indole
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC13H11FIN3
Molar mass355.155 g·mol−1
3D model (JSmol)
  • CCN1C=NC=C1C2=CNC3=C2C(=C(C=C3)I)F
  • InChI=1S/C13H11FIN3/c1-2-18-7-16-6-11(18)8-5-17-10-4-3-9(15)13(14)12(8)10/h3-7,17H,2H2,1H3
  • Key:KBQLQDPQEMFGCB-UHFFFAOYSA-N

AGH-192 is a potent and selective, water soluble, orally bioavailable and brain penetrant full agonist at the 5HT7 serotonin receptor, derived from the older drug AGH-107. In animal tests it showed activity indicative of potential application in the treatment of neuropathic pain.[1]

See also

References

  1. ^ Hogendorf AS, Hogendorf A, Popiolek-Barczyk K, Ciechanowska A, Mika J, Satała G, Walczak M, Latacz G, Handzlik J, Kieć-Kononowicz K, Ponimaskin E, Schade S, Zeug A, Bijata M, Kubicki M, Kurczab R, Lenda T, Staroń J, Kurczab R, Satała G, Lenda T, Walczak M, Latacz G, Handzlik J, Kieć-Kononowicz K, Wierońska JM, Woźniak M, Cieślik P, Bugno R, Staroń J, Bugno R, Duszyńska B, Pilarski B, Bojarski AJ (2019). "Fluorinated indole-imidazole conjugates: Selective orally bioavailable 5-HT7 receptor low-basicity agonists, potential neuropathic painkillers". European Journal of Medicinal Chemistry. 170: 261–275. doi:10.1016/j.ejmech.2019.03.017. PMID 30904783. S2CID 85498356.