1ZCA
2768
14673
ENSG00000146535
ENSMUSG00000000149
Q03113
P27600
NM_001282440NM_001282441NM_001293092NM_007353
NM_010302
NP_001269369NP_001269370NP_001280021NP_031379
NP_034432
Guanine nucleotide-binding protein subunit alpha-12 is a protein that in humans is encoded by the GNA12 gene.[5][6][7]
The GNA12 gene encodes the G12 G protein alpha subunit. Together with GNA13, these two proteins comprise one of the four classes of heterotrimeric G protein alpha subunits.[8] Heterotrimeric G proteins function in transducing hormone and neurotransmitter signals detected by cell surface G protein-coupled receptors to intracellular signaling pathways to modulate cell functions. G protein alpha subunits bind to guanine nucleotides and function in a regulatory cycle, and are active when bound to GTP but inactive and associated with the G beta-gamma complex when bound to GDP.[9][10]
Active GTP-bound G12 alpha subunit interacts with and activates ARHGEF1,[11] ARHGEF11,[12][13] and ARHGEF12.[14][15] These ARHGEF proteins function as guanine nucleotide exchange factors for the Rho small GTPases to regulate the actin cytoskeleton.[16]
GNA12 also interacts with PPP5C,[17] HSP90,[18] Resistance to inhibitors of cholinesterase-8A (Ric-8A)[19] and TEC.[15]
This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.
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