GNAL
Guanine nucleotide-binding protein G(olf) subunit alpha is a protein that in humans is encoded by the GNAL gene.[5][6] Its main product is the heterotrimeric G-protein alpha subunit Golf-α, a member of the Gs alpha subunit family that is a key component of G protein-coupled receptor-regulated adenylyl cyclase signal transduction pathways in the olfactory system and the striatum in the brain. It also mediated D1 receptor signalling in the striatum and is hence involved in motor control.[7]
See also
- Second messenger system
- G protein-coupled receptor
- Heterotrimeric G protein
- Adenylyl cyclase
- Protein kinase A
- Olfactory receptors
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000141404 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024524 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Wilkie TM, Gilbert DJ, Olsen AS, Chen XN, Amatruda TT, Korenberg JR, et al. (May 1992). "Evolution of the mammalian G protein alpha subunit multigene family". Nature Genetics. 1 (2): 85–91. doi:10.1038/ng0592-85. PMID 1302014. S2CID 31888533.
- ^ "Entrez Gene: GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type".
- ^ Zhuang X, Belluscio L, Hen R (August 2000). "G(olf)alpha mediates dopamine D1 receptor signaling". The Journal of Neuroscience. 20 (16) RC91. doi:10.1523/JNEUROSCI.20-16-j0001.2000. PMC 6772608. PMID 10924528.
Further reading
- Zigman JM, Westermark GT, LaMendola J, Boel E, Steiner DF (December 1993). "Human G(olf) alpha: complementary deoxyribonucleic acid structure and expression in pancreatic islets and other tissues outside the olfactory neuroepithelium and central nervous system". Endocrinology. 133 (6): 2508–2514. doi:10.1210/endo.133.6.8243272. PMID 8243272.
- Astesano A, Regnauld K, Ferrand N, Gingras D, Bendayan M, Rosselin G, et al. (March 1999). "Cellular and subcellular expression of Golf/Gs and Gq/G11 alpha-subunits in rat pancreatic endocrine cells". The Journal of Histochemistry and Cytochemistry. 47 (3): 289–302. doi:10.1177/002215549904700303. PMID 10026232.
- Vuoristo JT, Berrettini WH, Overhauser J, Prockop DJ, Ferraro TN, Ala-Kokko L (September 2000). "Sequence and genomic organization of the human G-protein Golfalpha gene (GNAL) on chromosome 18p11, a susceptibility region for bipolar disorder and schizophrenia". Molecular Psychiatry. 5 (5): 495–501. doi:10.1038/sj.mp.4000758. PMID 11032382. S2CID 23116111.
- Zill P, Engel R, Baghai TC, Zwanzger P, Schüle C, Minov C, et al. (March 2002). "Analysis of polymorphisms in the olfactory G-protein Golf in major depression". Psychiatric Genetics. 12 (1): 17–22. doi:10.1097/00041444-200203000-00002. PMID 11901355. S2CID 22757545.
- Régnauld K, Nguyen QD, Vakaet L, Bruyneel E, Launay JM, Endo T, et al. (June 2002). "G-protein alpha(olf) subunit promotes cellular invasion, survival, and neuroendocrine differentiation in digestive and urogenital epithelial cells". Oncogene. 21 (25): 4020–4031. doi:10.1038/sj.onc.1205498. PMID 12037684. S2CID 23730354.
- Zill P, Malitas PN, Bondy B, Engel R, Boufidou F, Behrens S, et al. (June 2003). "Analysis of polymorphisms in the alpha-subunit of the olfactory G-protein Golf in lithium-treated bipolar patients". Psychiatric Genetics. 13 (2): 65–69. doi:10.1097/01.ypg.0000057881.80011.45. PMID 12782961. S2CID 20253173.
- Corradi JP, Ravyn V, Robbins AK, Hagan KW, Peters MF, Bostwick R, et al. (November 2005). "Alternative transcripts and evidence of imprinting of GNAL on 18p11.2". Molecular Psychiatry. 10 (11): 1017–1025. doi:10.1038/sj.mp.4001713. PMID 16044173. S2CID 19513069.
- Ravyn V, Bostwick JR (2006). "Functional coupling of the Galpha(olf) variant XLGalpha(olf) with the human adenosine A2A receptor". Journal of Receptor and Signal Transduction Research. 26 (4): 241–258. doi:10.1080/10799890600710592. PMID 16818375. S2CID 27231567.
 | This article on a gene on human chromosome 18 is a stub. You can help Wikipedia by adding missing information. |
Content Disclaimer
Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.
- The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
- There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
- It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
- Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
- Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.