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GNG2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4KFM, 5HE3, 5HE0, 5HE2, 5HE1
Identifiers
Aliases	GNG2, G protein subunit gamma 2
External IDs	OMIM: 606981; MGI: 102705; HomoloGene: 40715; GeneCards: GNG2; OMA:GNG2 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	51,979,342 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	20,027,695 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; ganglionic eminence; ; left testis; ; right testis; ; bone marrow cells; ; Brodmann area 46; ; middle temporal gyrus; ; epithelium of colon; ; blood; ; spinal ganglia;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; ganglionic eminence; ; medial ganglionic eminence; ; dorsomedial hypothalamic nucleus; ; granulocyte; ; paraventricular nucleus of hypothalamus; ; arcuate nucleus; ; subiculum; ; lateral hypothalamus; ; median eminence;
	More reference expression data
	n/a
Gene ontology
Molecular function	signal transducer activity; G-protein beta-subunit binding; protein binding; GTPase activity;
Cellular component	heterotrimeric G-protein complex; plasma membrane; extracellular exosome; membrane; G-protein beta/gamma-subunit complex;
Biological process	cellular response to glucagon stimulus; cell population proliferation; signal transduction; cellular response to catecholamine stimulus; platelet activation; adenylate cyclase-activating dopamine receptor signaling pathway; cellular response to prostaglandin E stimulus; protein folding; Wnt signaling pathway, calcium modulating pathway; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	54331
	14702
	ENSG00000186469
	ENSMUSG00000043004
	P59768
	P63213
	NM_001243773; NM_001243774; NM_053064
NM_001038637; NM_001285908; NM_001285909; NM_001285910; NM_001285911;
	NM_010315
	NP_001230702; NP_001230703; NP_444292
NP_001033726; NP_001272837; NP_001272838; NP_001272839; NP_001272840;
	NP_034445
	Wikidata
View/Edit Human	View/Edit Mouse

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 is a protein that in humans is encoded by the GNG2 gene.^[5]^[6]

Heterotrimeric G proteins play vital roles in cellular responses to external signals. The specificity of a G protein-receptor interaction is primarily mediated by the gamma subunit.[supplied by OMIM]^[6]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.^{[§ 1]}

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|alt=Nicotine Activity on Dopaminergic Neurons edit]]

Nicotine Activity on Dopaminergic Neurons edit

^ The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602".

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000186469 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000043004 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Modarressi MH, Taylor KE, Wolfe J (Jul 2000). "Cloning, characterization, and mapping of the gene encoding the human G protein gamma 2 subunit". Biochem Biophys Res Commun. 272 (2): 610–5. doi:10.1006/bbrc.2000.2832. PMID 10833460.
^ ^a ^b "Entrez Gene: GNG2 guanine nucleotide binding protein (G protein), gamma 2".