1IAP, 1SHZ, 3AB3, 3ODO, 3ODW, 3ODX, 3P6A
9138
16801
ENSG00000076928
ENSMUSG00000040940
Q92888
Q61210
NM_004706NM_198977NM_199002
NM_001130150NM_001130151NM_001130152NM_001130153NM_008488
NP_004697NP_945328NP_945353
NP_001123622NP_001123623NP_001123624NP_001123625NP_032514
Rho guanine nucleotide exchange factor 1 is a protein that in humans is encoded by the ARHGEF1 gene.[5][6][7] This protein is also called RhoGEF1 or p115-RhoGEF.
Rho guanine nucleotide exchange factor 1 is guanine nucleotide exchange factor (GEF) for the RhoA small GTPase protein.[5] Rho is a small GTPase protein that is inactive when bound to the guanine nucleotide GDP. But when acted on by Rho GEF proteins such as RhoGEF1, this GDP is released and replaced by GTP, leading to the active state of Rho. In this active, GTP-bound conformation, Rho can bind to and activate specific effector proteins and enzymes to regulate cellular functions.[8] In particular, active Rho is a major regulator of the cell actin cytoskeleton.[8]
RhoGEF1 is a member of a group of four RhoGEF proteins known to be activated by G protein coupled receptors coupled to the G12 and G13 heterotrimeric G proteins.[9][10] The others are ARHGEF11 (also known as PDZ-RhoGEF), ARHGEF12 (also known as LARG) and AKAP13 (also known as ARHGEF13 and Lbc). [11][12] GPCR-regulated RhoGEF1 (and these related GEF proteins) acts as an effector for G12 and G13 G proteins. In addition to being activated by G12 or G13 G proteins, three of these four RhoGEF proteins (ARHGEF1/11/12) also function as RGS family GTPase-activating proteins (GAPs) to increase the rate of GTP hydrolysis of G12/G13 alpha proteins (which are themselves GTPase proteins). This action increases the rate of G protein deactivation, limiting the time during which these RhoGEFs activate Rho.[13]
Multiple alternatively spliced transcript variants have been identified for this gene, but the full-length nature and function of some variants has not been defined.[7]
ARHGEF1 has been shown to interact with:
This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.
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