Hromosom 10

Hromosom 10
Par ljudskih hromosoma 10 nakon G-pruganja.
Jedan j od majke, drugi od oca
Karakteristike
Dužina (bp)133,797,422 bp
(GRCh38)[1]
Br. gena706 (CCDS)[2]
VrstaAutosom
Pozicija centromereSubmetacentrik[3]
(39.8 Mbp)
Kompletan spisak gena
CCDSSpisak gena
HGNCSpisak gena
UniProtSpisak gena
NCBISpisak gena
Vanjski preglednici karata
EnsemblHromosom 10
EntrezHromosom 10
NCBIHromosom 10
UCSCHromosom 10
Potpune DNK sekvence
RefSeqNC_000010 (FASTA)
GenBankCM000672 (FASTA)
Par ljudskih hromosoma 10 u kariogramu muškarca

Hromosome 10 je jedan od 23 para hromosoma kod ljudi. Čovjek normalno ima njegove dvije kopije . Hromosom 10 spans ima oko 133 miliona baznih parova (gradivnog materijala DNK) i uključuje između 4 i 4,5 % ukupne DNK u ćelijama.

Geni

Broj gena

Slijede neke od procjena broja gena za ljudski hromosom 10. Budući da istraživači koriste različite pristupe označavanju genoma, njihova predviđanja broja gena na svakom hromosomu variraju (za tehničke detalje pogledajte predviđanje gena). Među različitim projektima, zajednički Projekt konsenzusnog kodiranja (CCDS) zauzima izuzetno konzervativnu strategiju. Dakle, predviđanje broja gena prema CCDS-u predstavlja donju granicu ukupnog broja gena koji kodiraju ljudske proteine.[4]

Baza podataka Protein-kodirajući geni Nkoirajući geni RNK Pseudogeni Izvor Datum objave
CCDS
706 — — [2] 2016-09-08
HGNC
 708 244 614 [5] 2017-05-12
Ensembl
 728 881 568 [6] 2017-03-29
UniProt
 750 — — [7] 2018-02-28
NCBI
754 842 654 [8][9][10] 2017-05-19

Lista gena

Slijedi djelimična lista gena na ljudskom hromosomu 10. Potpunu listu potražite u linku u informacijskom okviru s desne strane.

Bolesti i poremećaji

Sljedeće bolesti povezane su s genima na hromosomu 10:

Citogenetičke pruge

Isdiogram G-pruganog ljudskog hromosoma 10
Idiogram G-pruganog ljudskog hromosoma 10 u rezoluciji 850 bphs. Dužina pruga na ovom dijagramu proporcionalna je dužini osnovnog para. Ovaj tip idiograma obično se koristi u pretraživačima genoma (npr. Ensembl, UCSC pretraživač genoma.
Obrazac G-pruganja ljudskog hromosoma 10 u tri različite rezolucije (400,[11] 550[12] and 850[13]). Band length in this diagram is based on the ideograms from ISCN (2013).[14] Ovaj tip idiograma predstavlja stvarnu relativnu dužinu pruga uočenih pod mikroskopom u različitim fazama tokom procesa mitoze.[15]
G-pruge ljudskog hromosoma 10 u rezoluciji 850 bphs[13]
Hromosom Kraci: "p" – kratki ; "q" – dugi Band[16] ISCN
start[17] 		ISCN
stop[17] 		Bazni par
start 		Bazni par
stop 		Boja Gustoća
10 p 15.3 0 229 1 3.000.000 gneg
10 p 15.2 229 329 3.000.001 3.800.000 gpos 25
10 p 15.1 329 630 3.800.001 6.600.000 gneg
10 p 14 630 917 6.600.001 12.200.000 gpos 75
10 p 13 917 1175 12.200.001 17.300.000 gneg
10 p 12.33 1175 1361 17.300.001 18.300.000 gpos 75
10 p 12.32 1361 1432 18.300.001 18.400.000 gneg
10 p 12.31 1432 1604 18.400.001 22.300.000 gpos 75
10 p 12.2 1604 1662 22.300.001 24.300.000 gneg
10 p 12.1 1662 1891 24.300.001 29.300.000 gpos 50
10 p 11.23 1891 2063 29.300.001 31.100.000 gneg
10 p 11.22 2063 2235 31.100.001 34.200.000 gpos 25
10 p 11.21 2235 2406 34.200.001 38.000.000 gneg
10 p 11.1 2406 2621 38.000.001 39.800.000 acen
10 q 11.1 2621 2850 39.800.001 41.600.000 acen
10 q 11.21 2850 3051 41.600.001 45.500.000 gneg
10 q 11.22 3051 3252 45.500.001 48.600.000 gpos 25
10 q 11.23 3252 3409 48.600.001 51.100.000 gneg
10 q 21.1 3409 3753 51.100.001 59.400.000 gpos 100
10 q 21.2 3753 3839 59.400.001 62.800.000 gneg
10 q 21.3 3839 4097 62.800.001 68.800.000 gpos 100
10 q 22.1 4097 4469 68.800.001 73.100.000 gneg
10 q 22.2 4469 4655 73.100.001 75.900.000 gpos 50
10 q 22.3 4655 4970 75.900.001 80.300.000 gneg
10 q 23.1 4970 5200 80.300.001 86.100.000 gpos 100
10 q 23.2 5200 5331 86.100.001 87.700.000 gneg
10 q 23.31 5331 5558 87.700.001 91.100.000 gpos 75
10 q 23.32 5558 5672 91.100.001 92.300.000 gneg
10 q 23.33 5672 5887 92.300.001 95.300.000 gpos 50
10 q 24.1 5887 5973 95.300.001 97.500.000 gneg
10 q 24.2 5973 6131 97.500.001 100.100.000 gpos 50
10 q 24.31 6131 6202 100.100.001 101.200.000 gneg
10 q 24.32 6202 6317 101.200.001 103.100.000 gpos 25
10 q 24.33 6317 6374 103.100.001 104.000.000 gneg
10 q 25.1 6374 6646 104.000.001 110.100.000 gpos 100
10 q 25.2 6646 6761 110.100.001 113.100.000 gneg
10 q 25.3 6761 6890 113.100.001 117.300.000 gpos 75
10 q 26.11 6890 7090 117.300.001 119.900.000 gneg
10 q 26.12 7090 7219 119.900.001 121.400.000 gpos 50
10 q 26.13 7219 7506 121.400.001 125.700.000 gneg
10 q 26.2 7506 7721 125.700.001 128.800.000 gpos 50
10 q 26.3 7721 8050 128.800.001 133.797.422 gneg
Oznake: gpos – Regija koja je pozitivno obojena G-pruganjem, uglavnom AT-bogata i siromašna genima; gneg – Regija koja je negativno obojena G-prugama, općenito CG-bogata i bogata genima; acen Centromere; var – Varijabilna regija; stalk – drška.

References

  1. ^ "Human Genome Assembly GRCh38 - Genome Reference Consortium". National Center for Biotechnology Information (jezik: engleski). 24. 12. 2013. Pristupljeno 4. 3. 2017.
  2. ^ a b "Search results - 10[CHR] AND "Homo sapiens"[Organism] AND ("has ccds"[Properties] AND alive[prop]) - Gene". NCBI. CCDS Release 20 for Homo sapiens. 8. 9. 2016. Pristupljeno 28. 5. 2017.
  3. ^ Tom Strachan; Andrew Read (2. 4. 2010). Human Molecular Genetics. Garland Science. str. 45. ISBN 978-1-136-84407-2.
  4. ^ Pertea M, Salzberg SL (2010). "Between a chicken and a grape: estimating the number of human genes". Genome Biol. 11 (5): 206. doi:10.1186/gb-2010-11-5-206. PMC 2898077. PMID 20441615.
  5. ^ "Statistics & Downloads for chromosome 10". HUGO Gene Nomenclature Committee. 12. 5. 2017. Arhivirano s originala, 29. 6. 2017. Pristupljeno 19. 5. 2017.
  6. ^ "Chromosome 10: Chromosome summary - Homo sapiens". Ensembl Release 88. 29. 3. 2017. Pristupljeno 19. 5. 2017.
  7. ^ "Human chromosome 10: entries, gene names and cross-references to MIM". UniProt. 28. 2. 2018. Pristupljeno 16. 3. 2018.
  8. ^ "Search results - 10[CHR] AND "Homo sapiens"[Organism] AND ("genetype protein coding"[Properties] AND alive[prop]) - Gene". NCBI. 19. 5. 2017. Pristupljeno 20. 5. 2017.
  9. ^ "Search results - 10[CHR] AND "Homo sapiens"[Organism] AND ( ("genetype miscrna"[Properties] OR "genetype ncrna"[Properties] OR "genetype rrna"[Properties] OR "genetype trna"[Properties] OR "genetype scrna"[Properties] OR "genetype snrna"[Properties] OR "genetype snorna"[Properties]) NOT "genetype protein coding"[Properties] AND alive[prop]) - Gene". NCBI. 19. 5. 2017. Pristupljeno 20. 5. 2017.
  10. ^ "Search results - 10[CHR] AND "Homo sapiens"[Organism] AND ("genetype pseudo"[Properties] AND alive[prop]) - Gene". NCBI. 19. 5. 2017. Pristupljeno 20. 5. 2017.
  11. ^ Genome Decoration Page, NCBI. Ideogram data for Homo sapience (400 bphs, Assembly GRCh38.p3). Last update 2014-03-04. Retrieved 2017-04-26.
  12. ^ Genome Decoration Page, NCBI. Ideogram data for Homo sapience (550 bphs, Assembly GRCh38.p3). Last update 2015-08-11. Retrieved 2017-04-26.
  13. ^ a b Genome Decoration Page, NCBI. Ideogram data for Homo sapience (850 bphs, Assembly GRCh38.p3). Last update 2014-06-03. Retrieved 2017-04-26.
  14. ^ International Standing Committee on Human Cytogenetic Nomenclature (2013). ISCN 2013: An International System for Human Cytogenetic Nomenclature (2013). Karger Medical and Scientific Publishers. ISBN 978-3-318-02253-7.
  15. ^ Sethakulvichai, W.; Manitpornsut, S.; Wiboonrat, M.; Lilakiatsakun, W.; Assawamakin, A.; Tongsima, S. (2012). "Estimation of band level resolutions of human chromosome images". In Computer Science and Software Engineering (JCSSE), 2012 International Joint Conference on: 276–282. doi:10.1109/JCSSE.2012.6261965. ISBN 978-1-4673-1921-8.
  16. ^ For cytogenetic banding nomenclature, see article locus.
  17. ^ a b These values (ISCN start/stop) are based on the length of bands/ideograms from the ISCN book, An International System for Human Cytogenetic Nomenclature (2013). Arbitrary unit.
  • Deloukas P, Earthrowl ME, Grafham DV, Rubenfield M, French L, Steward CA, Sims SK, Jones MC, Searle S, Scott C, Howe K, Hunt SE, Andrews TD, Gilbert JG, Swarbreck D, Ashurst JL, Taylor A, Battles J, Bird CP, Ainscough R, Almeida JP, Ashwell RI, Ambrose KD, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Bates K, Beasley H, Bray-Allen S, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Cahill P, Camire D, Carter NP, Chapman JC, Clark SY, Clarke G, Clee CM, Clegg S, Corby N, Coulson A, Dhami P, Dutta I, Dunn M, Faulkner L, Frankish A, Frankland JA, Garner P, Garnett J, Gribble S, Griffiths C, Grocock R, Gustafson E, Hammond S, Harley JL, Hart E, Heath PD, Ho TP, Hopkins B, Horne J, Howden PJ, Huckle E, Hynds C, Johnson C, Johnson D, Kana A, Kay M, Kimberley AM, Kershaw JK, Kokkinaki M, Laird GK, Lawlor S, Lee HM, Leongamornlert DA, Laird G, Lloyd C, Lloyd DM, Loveland J, Lovell J, McLaren S, McLay KE, McMurray A, Mashreghi-Mohammadi M, Matthews L, Milne S, Nickerson T, Nguyen M, Overton-Larty E, Palmer SA, Pearce AV, Peck AI, Pelan S, Phillimore B, Porter K, Rice CM, Rogosin A, Ross MT, Sarafidou T, Sehra HK, Shownkeen R, Skuce CD, Smith M, Standring L, Sycamore N, Tester J, Thorpe A, Torcasso W, Tracey A, Tromans A, Tsolas J, Wall M, Walsh J, Wang H, Weinstock K, West AP, Willey DL, Whitehead SL, Wilming L, Wray PW, Young L, Chen Y, Lovering RC, Moschonas NK, Siebert R, Fechtel K, Bentley D, Durbin R, Hubbard T, Doucette-Stamm L, Beck S, Smith DR, Rogers J (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
  • Deloukas P, French L, Meitinger T, Moschonas NK (2000). "Report of the third international workshop on human chromosome 10 mapping and sequencing 1999". Cytogenet Cell Genet. 90 (1–2): 1–12. doi:10.1159/000015653. PMID 11060438.
  • Gilbert F (2001). "Chromosome 10". Genet Test. 5 (1): 69–82. doi:10.1089/109065701750168824. PMID 11336406.

Također pogledajte

Reference

  • Deloukas P, Earthrowl ME, Grafham DV, Rubenfield M, French L, Steward CA, Sims SK, Jones MC, Searle S, Scott C, Howe K, Hunt SE, Andrews TD, Gilbert JG, Swarbreck D, Ashurst JL, Taylor A, Battles J, Bird CP, Ainscough R, Almeida JP, Ashwell RI, Ambrose KD, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Bates K, Beasley H, Bray-Allen S, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Cahill P, Camire D, Carter NP, Chapman JC, Clark SY, Clarke G, Clee CM, Clegg S, Corby N, Coulson A, Dhami P, Dutta I, Dunn M, Faulkner L, Frankish A, Frankland JA, Garner P, Garnett J, Gribble S, Griffiths C, Grocock R, Gustafson E, Hammond S, Harley JL, Hart E, Heath PD, Ho TP, Hopkins B, Horne J, Howden PJ, Huckle E, Hynds C, Johnson C, Johnson D, Kana A, Kay M, Kimberley AM, Kershaw JK, Kokkinaki M, Laird GK, Lawlor S, Lee HM, Leongamornlert DA, Laird G, Lloyd C, Lloyd DM, Loveland J, Lovell J, McLaren S, McLay KE, McMurray A, Mashreghi-Mohammadi M, Matthews L, Milne S, Nickerson T, Nguyen M, Overton-Larty E, Palmer SA, Pearce AV, Peck AI, Pelan S, Phillimore B, Porter K, Rice CM, Rogosin A, Ross MT, Sarafidou T, Sehra HK, Shownkeen R, Skuce CD, Smith M, Standring L, Sycamore N, Tester J, Thorpe A, Torcasso W, Tracey A, Tromans A, Tsolas J, Wall M, Walsh J, Wang H, Weinstock K, West AP, Willey DL, Whitehead SL, Wilming L, Wray PW, Young L, Chen Y, Lovering RC, Moschonas NK, Siebert R, Fechtel K, Bentley D, Durbin R, Hubbard T, Doucette-Stamm L, Beck S, Smith DR, Rogers J (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.CS1 održavanje: više imena: authors list (link)
  • Deloukas P, French L, Meitinger T, Moschonas NK (2000). "Report of the third international workshop on human chromosome 10 mapping and sequencing 1999". Cytogenet Cell Genet. 90 (1–2): 1–12. doi:10.1159/000015653. PMID 11060438.CS1 održavanje: više imena: authors list (link)
  • Gilbert F (2001). "Chromosome 10". Genet Test. 5 (1): 69–82. doi:10.1089/109065701750168824. PMID 11336406.

Vanjski linkovi

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Commons ima datoteke na temu: Hromosom 10
  • National Institutes of Health. "Chromosome 10". Genetics Home Reference. Arhivirano s originala, 8. 4. 2010. Pristupljeno 6. 5. 2017.
  • "Chromosome 10". Human Genome Project Information Archive 1990–2003. Pristupljeno 6. 5. 2017.