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ZNF438
Identifikatori
Aliasi	ZNF438
Vanjski ID-jevi	MGI: 2444919 HomoloGene: 18695 GeneCards: ZNF438
Lokacija gena (čovjek)
Hrom.	Hromosom 10 (čovjek)
Kraj	31,031,937 bp
Lokacija gena (miš)
Hrom.	Hromosom 18 (miš)
Kraj	5,334,807 bp
Ontologija gena
Molekularna funkcija	• GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • vezivanje sa DNK; • vezivanje iona metala; • nucleic acid binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • sequence-specific DNA binding;
Ćelijska komponenta	• jedro; • nukleoplazma; • citosol;
Biološki proces	• GO:0045996 negative regulation of transcription, DNA-templated; • GO:0009373 regulation of transcription, DNA-templated; • transcription, DNA-templated; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II;
	Izvori:Amigo / QuickGO
Ortolozi
	220929
	240186
	ENSG00000183621
	ENSMUSG00000050945
	Q7Z4V0
	n/a
NM_001143766; NM_001143767; NM_001143768; NM_001143769; NM_001143770;
	NM_001143771; NM_182755; NM_001387405; NM_001387411; NM_001387412
	NM_178722; NM_001360447
NP_001137238; NP_001137239; NP_001137240; NP_001137241; NP_001137242;
	NP_001137243; NP_877432
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Protein cinkovog prsta 438 jest protein koji je kod ljudi kodiran genom ZNF438.^[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 828 aminokiselina, a molekulska težina 91.836.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MQNSVSVPPK	DEGESNIPSG	TIQSRKGLQN	KSQFRTIAPK	IVPKVLTSRM
LPCHSPSRSD	QVNLGPSINS	KLLGMSTQNY	ALMQVAGQEG	TFSLVALPHV
ASAQPIQKPR	MSLPENLKLP	IPRYQPPRNS	KASRKKPILI	FPKSGCSKAP
AQTQMCPQMS	PSPPHHPELL	YKPSPFEEVP	SLEQAPASIS	TAALTNGSDH
GDLRPPVTNT	HGSLNPPATP	ASSTPEEPAK	QDLTALSGKA	HFVSKITSSK
PSAVASEKFK	EQVDLAKTMT	NLSPTILGNA	VQLISSVPKG	KLPIPPYSRM
KTMEVYKIKS	DANIAGFSLP	GPKADCDKIP	STTEGFNAAT	KVASRLPVPQ
VSQQSACESA	FCPPTKLDLN	HKTKLNSGAA	KRKGRKRKVP	DEILAFQGKR
RKYIINKCRD	GKERVKNDPQ	EFRDQKLGTL	KKYRSIMPKP	IMVIPTLASL
ASPTTLQSQM	LGGLGQDVLL	NNSLTPKYLG	CKQDNSSSPK	PSSVFRNGFS
GIKKPWHRCH	VCNHHFQFKQ	HLRDHMNTHT	NRRPYSCRIC	RKSYVRPGSL
STHMKLHHGE	NRLKKLMCCE	FCAKVFGHIR	VYFGHLKEVH	RVVISTEPAP
SELQPGDIPK	NRDMSVRGME	GSLERENKSN	LEEDFLLNQA	DEVKLQIKCG
RCQITAQSFA	EIKFHLLDVH	GEEIEGRLQE	GTFPGSKGTQ	EELVQHASPD
WKRHPERGKP	EKVHSSSEES	HACPRLKRQL	HLHQNGVEML	MENEGPQSGT
NKPRETCQGP	ECPGLHTFLL	WSHSGFNCLL	CAEMLGRKED	LLHHWKHQHN
CEDPSKLWAI	LNTVSNQGVI	ELSSEAEK

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000183621 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000050945 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Zinc finger protein 438". Pristupljeno 26. 5. 2016.
^ "UniProt, Q7Z4V0". Pristupljeno 31. 8. 2021.

Dopunska literatura

Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A (2006). "A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease". Am. J. Hum. Genet. 78 (1): 78–88. doi:10.1086/498851. PMC 1380225. PMID 16385451.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000183621 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000050945 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Zinc finger protein 438". Pristupljeno 26. 5. 2016.

[UniProt-6] "UniProt, Q7Z4V0". Pristupljeno 31. 8. 2021.

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