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BAZ1B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1F62
Identifiers
Aliases	BAZ1B, WBSCR10, WBSCR9, WSTF, bromodomain adjacent to zinc finger domain 1B
External IDs	OMIM: 605681; MGI: 1353499; HomoloGene: 22651; GeneCards: BAZ1B; OMA:BAZ1B - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	73,522,293 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	135,274,983 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; ventricular zone; ; ganglionic eminence; ; sural nerve; ; Achilles tendon; ; cerebellar vermis; ; stromal cell of endometrium; ; islet of Langerhans; ; paraflocculus of cerebellum;
	Top expressed in
	Ileal epithelium; ; tail of embryo; ; mandibular prominence; ; maxillary prominence; ; genital tubercle; ; zygote; ; secondary oocyte; ; condyle; ; ventricular zone; ; tibiofemoral joint;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; histone kinase activity; histone binding; non-membrane spanning protein tyrosine kinase activity; metal ion binding; kinase activity; protein binding; protein tyrosine kinase activity; ATP binding; zinc ion binding;
Cellular component	pericentric heterochromatin; nuclear replication fork; nucleoplasm; condensed chromosome; nucleus; nuclear body;
Biological process	epigenetic maintenance of chromatin in transcription-competent conformation; chromatin remodeling; phosphorylation; transcription, DNA-templated; cellular response to DNA damage stimulus; peptidyl-tyrosine phosphorylation; regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	9031
	22385
	ENSG00000009954
	ENSMUSG00000002748
	Q9UIG0
	Q9Z277
	NM_023005; NM_032408; NM_001370402
	NM_011714
	NP_115784; NP_001357331
	NP_035844
	Wikidata
View/Edit Human	View/Edit Mouse

Tyrosine-protein kinase, or Bromodomain adjacent to zinc finger domain, 1B (BAZ1B) is an enzyme that in humans is encoded by the BAZ1B gene.^[5]^[6]^[7]

Function

This gene encodes a member of the bromodomain protein family. The bromodomain is a structural motif characteristic of proteins involved in chromatin-dependent regulation of transcription. This gene is deleted in Williams-Beuren syndrome, a developmental disorder caused by deletion of multiple genes at 7q11.23.^[7]

BAZ1B has been found to affect the activity of 448 other genes and is very important in the development of the neural crest and the face. Research suggests that changes in BAZ1B may have been involved in "self-domesticating" humans.^[8]^[9]