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BATF
Identifiers
Aliases	BATF, B-ATF, BATF1, SFA-2, SFA2, basic leucine zipper ATF-like transcription factor
External IDs	OMIM: 612476; MGI: 1859147; HomoloGene: 4666; GeneCards: BATF; OMA:BATF - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	75,546,993 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	85,755,861 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; blood; ; monocyte; ; spleen; ; lymph node; ; appendix; ; palpebral conjunctiva; ; testicle; ; bone marrow; ; olfactory zone of nasal mucosa;
	Top expressed in
	granulocyte; ; embryo; ; spleen; ; embryo; ; lymph node; ; blood; ; mesenteric lymph nodes; ; thymus; ; parotid gland; ; subcutaneous adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA binding; sequence-specific DNA binding; DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nucleoplasm; nucleus;
Biological process	regulation of transcription by RNA polymerase II; cell differentiation; regulation of transcription, DNA-templated; transcription, DNA-templated; transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; T-helper 2 cell differentiation; cytokine production; DNA damage response, signal transduction by p53 class mediator; myeloid dendritic cell differentiation; lymphoid progenitor cell differentiation; T-helper 17 cell lineage commitment; cellular response to DNA damage stimulus; hematopoietic stem cell differentiation; isotype switching; T-helper 17 cell differentiation; defense response to protozoan; cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	10538
	53314
	ENSG00000156127
	ENSMUSG00000034266
	Q16520
	O35284
	NM_006399
	NM_016767
	NP_006390
	NP_058047
	Wikidata
View/Edit Human	View/Edit Mouse

Basic leucine zipper transcription factor, ATF-like, also known as BATF, is a protein which in humans is encoded by the BATF gene.^[5]^[6]^[7]

Function

The protein encoded by this gene is a nuclear basic leucine zipper (bZIP) protein that belongs to the AP-1/ATF superfamily of transcription factors. The leucine zipper of this protein mediates dimerization with members of the Jun family of proteins. This protein is thought to be a negative regulator of AP-1/ATF transcriptional events.^[7]

Mice without the BATF gene (BATF knockout mice) lacked a type of inflammatory immune cell (Th17) and were resistant to conditions that normally induces an autoimmune condition similar to multiple sclerosis.^[8]

Interactions

BATF (gene) has been shown to interact with IFI35.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000156127 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034266 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dorsey MJ, Tae HJ, Sollenberger KG, Mascarenhas NT, Johansen LM, Taparowsky EJ (December 1995). "B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family". Oncogene. 11 (11): 2255–65. PMID 8570175.
^ Hasegawa H, Utsunomiya Y, Kishimoto K, Tange Y, Yasukawa M, Fujita S (May 1996). "SFA-2, a novel bZIP transcription factor induced by human T-cell leukemia virus type I, is highly expressed in mature lymphocytes". Biochem. Biophys. Res. Commun. 222 (1): 164–70. doi:10.1006/bbrc.1996.0700. PMID 8630063.
^ ^a ^b "Entrez Gene: BATF basic leucine zipper transcription factor, ATF-like".
^
Schraml BU, Hildner K, Ise W, Lee WL, Smith WA, Solomon B, Sahota G, Sim J, Mukasa R, Cemerski S, Hatton RD, Stormo GD, Weaver CT, Russell JH, Murphy TL, Murphy KM (July 2009). "The AP-1 transcription factor Batf controls TH17 differentiation". Nature. 460 (7253): 405–9. Bibcode:2009Natur.460..405S. doi:10.1038/nature08114. PMC 2716014. PMID 19578362.
- "Gene regulates immune cells' ability to harm the body". EurekAlert! (Press release). 2009-07-16.
^ Wang X, Johansen LM, Tae HJ, Taparowsky EJ (1996). "IFP 35 forms complexes with B-ATF, a member of the AP1 family of transcription factors". Biochem. Biophys. Res. Commun. 229 (1): 316–22. doi:10.1006/bbrc.1996.1799. PMID 8954125.