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NFATC1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1A66, 1NFA
Identifiers
Aliases	NFATC1, NF-ATC, NFAT2, NFATc, NF-ATc1.2, nuclear factor of activated T-cells 1, nuclear factor of activated T cells 1
External IDs	OMIM: 600489; MGI: 102469; HomoloGene: 32336; GeneCards: NFATC1; OMA:NFATC1 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	79,529,325 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	80,756,286 bp
RNA expression pattern
	Top expressed in
	oocyte; ; muscle of thigh; ; secondary oocyte; ; Skeletal muscle tissue of rectus abdominis; ; triceps brachii muscle; ; gastrocnemius muscle; ; Skeletal muscle tissue of biceps brachii; ; sural nerve; ; glutes; ; vastus lateralis muscle;
	Top expressed in
	granulocyte; ; mesenteric lymph nodes; ; endocardial cushion; ; triceps brachii muscle; ; muscle of thigh; ; olfactory epithelium; ; knee joint; ; temporal muscle; ; blood; ; ankle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity; mitogen-activated protein kinase p38 binding; FK506 binding; DNA-binding transcription activator activity, RNA polymerase II-specific; protein binding; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; DNA-binding transcription factor activity, RNA polymerase II-specific; chromatin binding; transcription factor binding;
Cellular component	cytoplasm; cytosol; nucleus; nucleoplasm; nuclear body; transcription regulator complex;
Biological process	intracellular signal transduction; regulation of transcription, DNA-templated; calcineurin-NFAT signaling cascade; transcription by RNA polymerase II; transcription, DNA-templated; positive regulation of transcription, DNA-templated; Fc-epsilon receptor signaling pathway; positive regulation of transcription by RNA polymerase II; Wnt signaling pathway, calcium modulating pathway; negative regulation of Wnt signaling pathway; negative regulation of vascular associated smooth muscle cell differentiation; cytokine production; aortic valve morphogenesis; pulmonary valve morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	4772
	18018
	ENSG00000131196
	ENSMUSG00000033016
	O95644
	O88942
NM_172390; NM_001278669; NM_001278670; NM_001278672; NM_001278673;
	NM_001278675; NM_006162; NM_172387; NM_172388; NM_172389
NM_001164109; NM_001164110; NM_001164111; NM_001164112; NM_016791;
	NM_198429
NP_001265598; NP_001265599; NP_001265601; NP_001265602; NP_001265604;
	NP_006153; NP_765975; NP_765976; NP_765977; NP_765978
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Nuclear factor of activated T-cells, cytoplasmic 1 is a protein that in humans is encoded by the NFATC1 gene.^[5]

Function

The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as ciclosporin. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes.^[6]