Homeobox protein Hox-A11 is a protein that in humans is encoded by the HOXA11gene.[5][6][7]
Function
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is involved in the regulation of uterine development and is required for female fertility. Mutations in this gene can cause radioulnar synostosis with amegakaryocytic thrombocytopenia.[7]
Davies JA, Fisher CE (2002). "Genes and proteins in renal development". Experimental Nephrology. 10 (2): 102–13. doi:10.1159/000049905 (inactive 1 November 2024). PMID11937757. S2CID22273851.{{cite journal}}: CS1 maint: DOI inactive as of November 2024 (link)
Fleischman RA, Letestu R, Mi X, Stevens D, Winters J, Debili N, Vainchenker W (Feb 2002). "Absence of mutations in the HoxA10, HoxA11 and HoxD11 nucleotide coding sequences in thrombocytopenia with absent radius syndrome". British Journal of Haematology. 116 (2): 367–75. doi:10.1046/j.1365-2141.2002.03263.x. PMID11841440. S2CID46162989.
Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N (Feb 2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology. 65 (2): 50–62. doi:10.1002/tera.10009. PMID11857506.
