喬安妮·史特布比

喬安妮·史特布比
2009年喬安妮·史特布比獲頒美国国家科学奖章
出生 (1946-06-11) 1946年6月11日78歲)
 美国伊利諾州香檳
国籍 美国
教育程度宾夕法尼亚大学(化學學士)
加利福尼亞大學柏克萊分校(有機化學博士)
知名于核糖核苷酸還原酶研究
奖项辉瑞酶化学奖(1986年)、美国国家科学奖章(2008年)、富蘭克林研究所化學獎(2010年)等
科学生涯
研究领域酶化學
机构麻省理工學院
学术指导者喬治·L·肯尼恩、朱利叶斯·里贝克羅伯特·埃伯利斯德语Robert H. Abeles

喬安妮·史特布比(英語:JoAnne Stubbe,1946年6月11日)為美國生物化學家、麻省理工學院化學系與生物學系榮譽教授(2017年退休[1]),研究主題為核糖核苷酸還原酶等多種酵素的結構、功能與反應機理,2008年獲頒美國國家科學獎章[2]

生平

喬安妮·史特布比於1946年生於伊利諾州香檳[3],1968年自宾夕法尼亚大学獲學士學位(主修化學)[4],大學時期在Edward R. Thornton實驗室參與研究[3],1971年自加利福尼亞大學柏克萊分校獲有機化學博士學位,指導教授為喬治·L·肯尼恩(George L. Kenyon)[3]。1971年-1972年她在加利福尼亞大學洛杉磯分校朱利叶斯·里贝克的實驗室進行短期的博士後研究,研究以色氨酸合成麥角酸二乙醯胺(LSD)的反應。1972年-1977年史特布比任教於威廉姆斯学院,但後來發覺自己志不在教學,乃至布蘭戴斯大學羅伯特·埃伯利斯德语Robert H. Abeles實驗室進行第二段博士後研究,主題為酶抑制劑[5][6]

1977年-1980年史特布比於耶魯醫學院藥學系擔任助理教授[7],1980年任威斯康星大學麥迪遜分校生物化學系助理教授,1985年升為正教授[7];1987年史特布比任麻省理工學院化學系英语MIT Chemistry Department教授,為該系第一個得到終身教職的女性教授[8],並於1990年獲同校生物學系英语MIT Department of Biology合聘。2009年史特布比因「對核糖核苷酸還原酶作用機制開創性的貢獻,精巧地利用化學技術解答生物學問題」而獲頒美國國家科學獎章[8][9]。2017年史特布比自麻省理工學院退休[1]

研究

喬安妮·史特布比共發表了超過300篇學術論文[10],其研究結果闡明了許多種酵素的反應機構,她早年的研究結果解開了烯醇化酶丙酮酸激酶(皆為糖酵解所需的酵素)的反應機構[6][7],且為使用光譜儀解析酵素與受質交互作用的先驅[11]。後來史特布比以核糖核苷酸還原酶為主要研究領域,研究此酵素將核苷酸轉為脱氧核苷酸的機制[12]。此外史特布比的研究主題還包括抗生素博來黴素的結構與作用機理[5]、細菌合成聚羥基丁酸酯(PHA)的機制[13]、設計DNA修復酵素的自殺性抑制物[7]

個人生活

喬安妮·史特布比的父母均為教師,因此她曾打算也以教師為業[6]。因她做實驗時工時很長,史特布比曾在研究室放置一張床以便休息[6]。史特布比還養有一隻寵物狗,名為"Dr. McEnzyme Stubbe",在其實驗室網站上被列為實驗室的成員之一[14][15]

榮譽

參考文獻

  1. ^ 1.0 1.1 Lippard and Stubbe Honored with Retirement Reception – MIT Department of Chemistry. [2019-06-29]. (原始内容存档于2021-02-25). 
  2. ^ JoAnne Stubbe. National Science and Technology Medals Foundation. [2021-12-27]. (原始内容存档于2021-12-27). 
  3. ^ 3.0 3.1 3.2 3.3 Iii and Potuzak. The 2010 Benjamin Franklin meal in chemistry presented to JoAnne Stubbe. Journal of the Franklin Institute. 2014. 
  4. ^ JoAnne Stubbe. MIT Department of Biology. [2019-06-29]. (原始内容存档于2021-05-09). 
  5. ^ 5.0 5.1 Stubbe wins faculty's Killian Award. MIT News. [2016-01-28]. (原始内容存档于2021-01-23). 
  6. ^ 6.0 6.1 6.2 6.3 Hopkin, K. JoAnne Stubbe - Making life possible. The Scientist. 2007. 
  7. ^ 7.0 7.1 7.2 7.3 7.4 JoAnne Stubbe, Prof.. www.chem.uzh.ch. 3rd annual Dorothy Crowfoot Hodgkin Interdisciplinary Symposium. 2008 [2016-04-13]. (原始内容存档于2017-05-10). 
  8. ^ 8.0 8.1 8.2 Johnson, Carolyn Y. White House to give MIT scientist top honor. Boston.com. 2009-09-18 [2019-06-29]. (原始内容存档于2019-06-29). 
  9. ^ 9.0 9.1 Anne Trafton, MIT News Office. Biochemist JoAnne Stubbe wins National Medal of Science. MIT News. 2009-09-17 [2021-12-07]. (原始内容存档于2013-02-16). 
  10. ^ American Chemical Society names JoAnne Stubbe 2020 Priestley Medalist. American Chemical Society. [2019-06-29]. (原始内容存档于2021-02-28). 
  11. ^ Nakanishi Prize, Chemical & Engineering News, 2009-02-09: 41–42 
  12. ^ Making Life Possible | The Scientist Magazine®. The Scientist. [2016-01-28]. (原始内容存档于2017-05-11). 
  13. ^ JoAnne Stubbe Research Group - MIT. web.mit.edu. [2016-01-28]. (原始内容存档于2021-07-29). 
  14. ^ 14.0 14.1 Abreu, Menino, Pagels, and Oprah: The Honorands. Harvard Magazine. 2013-05-30 [2020-01-29]. (原始内容存档于2021-06-09) (英语). 
  15. ^ JoAnne Stubbe Research Group - MIT. web.mit.edu. [2020-01-29]. (原始内容存档于2021-07-29). 
  16. ^ Academy of Arts & Sciences Website Search. amacad.org. [2016-01-28]. [失效連結]
  17. ^ JoAnne Stubbe. www.nasonline.org. [2019-06-29]. (原始内容存档于2019-11-03). 
  18. ^ Eight Faculty Elected to NAS. MIT News. [2016-01-28]. (原始内容存档于2021-02-26). 
  19. ^ Arthur C. Cope Scholar Awards. American Chemical Society. [2021-12-07]. (原始内容存档于2021-11-02). 
  20. ^ Alfred Bader Award in Bioinorganic or Bioorganic Chemistry. American Chemical Society. [2021-12-07]. (原始内容存档于2021-11-02). 
  21. ^ F. A. Cotton Medal for Excellence Chemical Research. [2021-12-07]. (原始内容存档于2020-07-01). 
  22. ^ Awards and Honors. MIT News. [2016-01-28]. (原始内容存档于2021-02-26). 
  23. ^ Repligen Corporation Award in Chemistry of Biological Processes (PDF). [2021-12-07]. (原始内容存档 (PDF)于2014-07-17). 
  24. ^ John Scott Award Recipients. www.garfield.library.upenn.edu. [2019-06-29]. (原始内容存档于2021-05-15). 
  25. ^ NAS Award in Chemical Sciences. www.nasonline.org. [2019-06-29]. (原始内容存档于2011-11-26). 
  26. ^ Linda Wang. Kirkwood Medal To JoAnne Stubbe. cen.acs.org. 2008-09-29 [2019-06-29]. (原始内容存档于2019-06-29). 
  27. ^ Nakanishi Prize. American Chemical Society. [2019-06-29]. (原始内容存档于2019-05-26). 
  28. ^ JoAnne Stubbe Wins Prelog Medal. cen.acs.org. Chemical & Engineering News. [2016-01-28]. 
  29. ^ Franklin Institute Laureate Page for JoAnne Stubbe. [2021-12-07]. (原始内容存档于2010-04-24). 
  30. ^ Welch Award Listing of Recipients 互联网档案馆存檔,存档日期2011-09-30.
  31. ^ Murray Goodman Memorial Prize. onlinelibrary.wiley.com. [2019-06-29]. doi:10.1002/(ISSN)1097-0282. (原始内容存档于2021-09-08). 
  32. ^ Distinguished Alumni Award | Department of Chemistry. www.chem.upenn.edu. [2016-04-13]. (原始内容存档于2019-07-21). 
  33. ^ Wang, Linda. 2015 Remsen Award To JoAnne Stubbe | Chemical & Engineering News. cen.acs.org. [2016-04-13]. (原始内容存档于2018-10-19). 
  34. ^ JoAnne Stubbe. Greengard Prize. [2019-06-29]. (原始内容存档于2019-05-28). 
  35. ^ JoAnne Stubbe wins Pearl Meister Greengard Prize. MIT News. [2019-06-29]. (原始内容存档于2021-01-25). 
  36. ^ Celia Henry Arnaud. JoAnne Stubbe Named 2020 Priestley Medalist. [2019-06-19]. (原始内容存档于2021-11-02). 
  37. ^ American Chemical Society names JoAnne Stubbe 2020 Priestley Medalist. American Chemical Society. [2019-06-29]. (原始内容存档于2021-02-28). 

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