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5-HT4受體
識別號
别名	HTR4；, 5-HT4, 5-HT4R, 5-HT4 receptor, 5-hydroxytryptamine receptor 4
外部ID	OMIM：602164 MGI：109246 HomoloGene：20243 GeneCards：HTR4
為以下藥物的標靶
	维拉佐酮、血清素、5-甲氧基色胺、α-methyl-5-HT、莫沙必利、伦扎必利、扎考必利、普芦卡必利、RS 67333、GR-113808、哌波色罗、SB 204070、levosulpiride、齐美定、capeserod、relenopride、td-8954、metoclopramide hydrochloride hydrate
基因位置（人类）
染色体	5號染色體
终止	148,677,235 bp
基因位置（小鼠）
染色体	小鼠18号染色体
终止	62,629,648 bp
RNA表达模式
	; ; ; ;
	查阅更多表达数据
基因本體
分子功能	• G protein-coupled receptor activity; • signal transducer activity; • G protein-coupled serotonin receptor activity; • trace-amine receptor activity; • 相同蛋白质结合; • neurotransmitter receptor activity; • 血浆蛋白结合;
細胞組分	• 細胞質; • integral component of membrane; • 核内体; • 细胞膜; • integral component of plasma membrane; • 膜; • 树突;
生物學過程	• gamma-aminobutyric acid signaling pathway; • G protein-coupled receptor signaling pathway; • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; • regulation of appetite; • 訊息傳遞; • 化学性突触传递; • G protein-coupled serotonin receptor signaling pathway;
	Sources:Amigo / QuickGO
直系同源
	3360
	15562
	ENSG00000164270
	ENSMUSG00000026322
	Q13639
	P97288
NM_000870; NM_001040169; NM_001040172; NM_001040173; NM_001040174;
	NM_001286410; NM_199453
	NM_008313; NM_001364956; NM_001364957; NM_001364958; NM_001364959
NP_000861; NP_001035259; NP_001035262; NP_001035263; NP_001273339;
	NP_955525
	NP_032339; NP_001351885; NP_001351886; NP_001351887; NP_001351888
	維基數據
檢視/編輯人類	檢視/編輯小鼠

5-HT₄受體或5-羥色胺受體4（英語：5-Hydroxytryptamine receptor 4）是在人類上由HTR4基因編碼的蛋白質^[6]^[7]。

配體

激動劑

BIMU-8（英语：BIMU-8）
Cisapride（英语：Cisapride）
ML-10302^[8]
莫沙必利
Prucalopride（英语：Prucalopride）
Renzapride（英语：Renzapride）
RS-67506
Tegaserod（英语：Tegaserod）
Zacopride
Metoclopramide
舒必利
RS-67333（英语：RS-67333） - partial agonist
SL65.0155（英语：SL65.0155） - partial agonist
CJ-033,466（英语：CJ-033,466） - partial agonist

拮抗劑

Piboserod（英语：Piboserod）
GR-113,808（英语：GR-113,808） (1-methyl-1H-indole-3-carboxylic acid, [1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]methyl ester)^[9]
GR-125,487
RS-39604 (1-[4-Amino-5-chloro-2-(3,5-dimethoxyphenyl)methyloxy]-3-[1-[2-methylsulphonylamino]piperidin-4-yl]propan-1-one)
SB-203,186
SB-204,070（英语：SB-204,070）
([Methoxy-¹¹C]1-butylpiperidin-4-yl)methyl 4-amino-3-methoxybenzoate^[10]
洋甘菊(酒精萃取)^[11]

參見

參考資料

^ 對5-hydroxytryptamine receptor 4起作用的藥物；在維基數據上查看/編輯參考.
^ ^2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000164270 - Ensembl, May 2017
^ ^3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000026322 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Claeysen S, Faye P, Sebben M, Lemaire S, Bockaert J, Dumuis A, Taviaux S. Assignment of 5-hydroxytryptamine receptor (HTR4) to human chromosome 5 bands q31-->q33 by in situ hybridization. Cytogenetics and Cell Genetics. December 1997, 78 (2): 133–4. PMID 9371406. doi:10.1159/000134646.
^ Blondel O, Vandecasteele G, Gastineau M, Leclerc S, Dahmoune Y, Langlois M, Fischmeister R. Molecular and functional characterization of a 5-HT4 receptor cloned from human atrium. FEBS Letters. August 1997, 412 (3): 465–74. PMID 9276448. doi:10.1016/S0014-5793(97)00820-X.
^ Godínez-Chaparro B, Barragán-Iglesias P, Castañeda-Corral G, Rocha-González HI, Granados-Soto V. Role of peripheral 5-HT(4), 5-HT(6), and 5-HT(7) receptors in development and maintenance of secondary mechanical allodynia and hyperalgesia. Pain. March 2011, 152 (3): 687–97. PMID 21239110. doi:10.1016/j.pain.2010.12.020.
^ Gale JD, Grossman CJ, Whitehead JW, Oxford AW, Bunce KT, Humphrey PP. GR113808: a novel, selective antagonist with high affinity at the 5-HT4 receptor. British Journal of Pharmacology. January 1994, 111 (1): 332–8. PMC 1910004 . PMID 8012715. doi:10.1111/j.1476-5381.1994.tb14064.x.
^ Xu R, Hong J, Morse CL, Pike VW. Synthesis, structure-affinity relationships, and radiolabeling of selective high-affinity 5-HT4 receptor ligands as prospective imaging probes for positron emission tomography. Journal of Medicinal Chemistry. October 2010, 53 (19): 7035–47. PMC 2951497 . PMID 20812727. doi:10.1021/jm100668r.
^ Simmen U, Kelber O, Okpanyi SN, Jaeggi R, Bueter B, Weiser D. Binding of STW 5 (Iberogast) and its components to intestinal 5-HT, muscarinic M3, and opioid receptors. Phytomedicine: 51–5. PMID 16973340. doi:10.1016/j.phymed.2006.03.012.

深入閱讀

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