LY-272,015

LY-272,015
臨床資料
其他名稱LY-272,015; 1-[(3,4-Dimethoxyphenyl)methy]-2,3,4,9-tetrahydro-6-methyl-1H-pyrido[3,4-b]indole
识别信息
  • 1-(3,4-dimethoxybenzyl)-6-methyl-2,3,4,9-tetrahydro-1H-β-carboline
CAS号172895-15-7  checkY
PubChem CID
ChemSpider
UNII
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)
化学信息
化学式C21H24N2O2
摩尔质量336.44 g·mol−1
3D模型（JSmol（英语：JSmol））
  • c4cc(C)cc3c4[nH]c2c3CCNC2Cc(cc1OC)ccc1OC
  • InChI=1S/C21H24N2O2/c1-13-4-6-17-16(10-13)15-8-9-22-18(21(15)23-17)11-14-5-7-19(24-2)20(12-14)25-3/h4-7,10,12,18,22-23H,8-9,11H2,1-3H3
  • Key:GDAJGLDMCDMPIR-UHFFFAOYSA-N

LY-272,015是一种有机化合物，化学式为C21H24N2O2，属于β-咔啉衍生物，能作为血清素受体5-HT2B的拮抗剂，由礼来公司作为高血壓药物研发[1][2]。

参考文献

  1. ^ Watts SW, Fink GD. 5-HT2B-receptor antagonist LY-272015 is antihypertensive in DOCA-salt-hypertensive rats. The American Journal of Physiology. March 1999, 276 (3): H944–52. PMID 10070078. S2CID 13301249. doi:10.1152/ajpheart.1999.276.3.H944. 
  2. ^ Russell A, Banes A, Berlin H, Fink GD, Watts SW. 5-Hydroxytryptamine(2B) receptor function is enhanced in the N(omega)-nitro-L-arginine hypertensive rat. The Journal of Pharmacology and Experimental Therapeutics. October 2002, 303 (1): 179–87. PMID 12235249. S2CID 98055109. doi:10.1124/jpet.102.037390. 

外部链接