RGS3

Regulator G-proteinske signalizacije 3
	; PDB prikaz baziran na 2f5y.
Dostupne strukture
	2F5Y, 2OJ4, 3FBK
Identifikatori
Simboli	RGS3; C2PA; RGP3
Vanjski ID	OMIM: 602189 MGI: 1354734 HomoloGene: 32440 GeneCards: RGS3 Gene
Ontologija gena
Molekulska funkcija	• aktivnost GTPaznog aktivatora
Ćelijska komponenta	• nukleus • citoplazma • citosol
Biološki proces	• inaktivacija MAPK aktivnosti • regulacija signalnog puta G-protein spregnutog receptora
Pregled RNK izražavanja
	podaci
Ortolozi

edit

Regulator G-proteinske signalizacije 3 je protein koji je kod ljudi kodiran RGS3 genom.^[1]^[2]^[3]

Ovaj gen kodira člana familje regulatora G-proteinske signalizacije (RGS). Taj protein je GTPazni aktivirajući protein koji inhibira G-proteinom posredovani prenos signala. Protein je uglavnom citosolan, dok G-proteinska aktivacija dovodi do translokacije tog proteina do ćelijske membrane. Nuklearna forma tog proteina je opisana, mada njegova sekvenca nije identifikovana. Višestruke alternativno splajsovane transkriptne varijante su opisane. Priroda transkripta pune dužine nije poznata.^[3]

Reference

↑ Druey KM, Blumer KJ, Kang VH, Kehrl JH (May 1996). „Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family”. Nature 379 (6567): 742–6. DOI:10.1038/379742a0. PMID 8602223.
↑ Linares JL, Wendling C, Tomasetto C, Rio MC (Nov 2000). „C2PA, a new protein expressed during mouse spermatogenesis”. FEBS Lett 480 (2–3): 249–54. DOI:10.1016/S0014-5793(00)01942-6. PMID 11034339.
↑ ^3,0 ^3,1 „Entrez Gene: RGS3 regulator of G-protein signalling 3”.

Literatura

Maruyama K, Sugano S (1994). „Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides”. Gene 138 (1–2): 171–4. DOI:10.1016/0378-1119(94)90802-8. PMID 8125298.
Chatterjee TK, Eapen A, Kanis AB, Fisher RA (1998). „Genomic organization, 5'-flanking region, and chromosomal localization of the human RGS3 gene”. Genomics 45 (2): 429–33. DOI:10.1006/geno.1997.4929. PMID 9344672.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K i dr.. (1997). „Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library”. Gene 200 (1–2): 149–56. DOI:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Dulin NO, Sorokin A, Reed E i dr.. (1999). „RGS3 Inhibits G Protein-Mediated Signaling via Translocation to the Membrane and Binding to Gα11”. Mol. Cell. Biol. 19 (1): 714–23. PMC 83928. PMID 9858594.
Dulin NO, Pratt P, Tiruppathi C i dr.. (2000). „Regulator of G protein signaling RGS3T is localized to the nucleus and induces apoptosis”. J. Biol. Chem. 275 (28): 21317–23. DOI:10.1074/jbc.M910079199. PMID 10749886.
Shi CS, Lee SB, Sinnarajah S i dr.. (2001). „Regulator of G-protein signaling 3 (RGS3) inhibits Gbeta1gamma 2-induced inositol phosphate production, mitogen-activated protein kinase activation, and Akt activation”. J. Biol. Chem. 276 (26): 24293–300. DOI:10.1074/jbc.M100089200. PMID 11294858.
Lu Q, Sun EE, Klein RS, Flanagan JG (2001). „Ephrin-B reverse signaling is mediated by a novel PDZ-RGS protein and selectively inhibits G protein-coupled chemoattraction”. Cell 105 (1): 69–79. DOI:10.1016/S0092-8674(01)00297-5. PMID 11301003.
Mittmann C, Schüler C, Chung CH i dr.. (2001). „Evidence for a short form of RGS3 preferentially expressed in the human heart”. Naunyn Schmiedebergs Arch. Pharmacol. 363 (4): 456–63. DOI:10.1007/s002100000376. PMID 11330340.
Niu J, Scheschonka A, Druey KM i dr.. (2002). „RGS3 interacts with 14-3-3 via the N-terminal region distinct from the RGS (regulator of G-protein signalling) domain”. Biochem. J. 365 (Pt 3): 677–84. DOI:10.1042/BJ20020390. PMC 1222729. PMID 11985497.
Kehrl JH, Srikumar D, Harrison K i dr.. (2002). „Additional 5' exons in the RGS3 locus generate multiple mRNA transcripts, one of which accounts for the origin of human PDZ-RGS3”. Genomics 79 (6): 860–8. DOI:10.1006/geno.2002.6773. PMID 12036301.
Ikeda M, Okai M, Miyoshi T i dr.. (2003). „Transcriptional suppression of the estrogen receptor by truncated estrogen receptor-alpha”. Horm. Metab. Res. 34 (8): 425–30. DOI:10.1055/s-2002-33599. PMID 12198596.
Hirabayashi S, Ohno H, Iida J, Hata Y (2003). „C2PA is a nuclear protein implicated in the heat shock response”. J. Cell. Biochem. 87 (1): 65–74. DOI:10.1002/jcb.10279. PMID 12210723.
Strausberg RL, Feingold EA, Grouse LH i dr.. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T i dr.. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039.
Humphray SJ, Oliver K, Hunt AR i dr.. (2004). „DNA sequence and analysis of human chromosome 9”. Nature 429 (6990): 369–74. DOI:10.1038/nature02465. PMC 2734081. PMID 15164053.
Tovey SC, Willars GB (2005). „Single-cell imaging of intracellular Ca2+ and phospholipase C activity reveals that RGS 2, 3, and 4 differentially regulate signaling via the Galphaq/11-linked muscarinic M3 receptor”. Mol. Pharmacol. 66 (6): 1453–64. DOI:10.1124/mol.104.005827. PMID 15383626.
Gerhard DS, Wagner L, Feingold EA i dr.. (2004). „The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T i dr.. (2005). „Towards a proteome-scale map of the human protein-protein interaction network”. Nature 437 (7062): 1173–8. DOI:10.1038/nature04209. PMID 16189514.

[pmid8602223-1] Druey KM, Blumer KJ, Kang VH, Kehrl JH (May 1996). „Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family”. Nature 379 (6567): 742–6. DOI:10.1038/379742a0. PMID 8602223.

[pmid11034339-2] Linares JL, Wendling C, Tomasetto C, Rio MC (Nov 2000). „C2PA, a new protein expressed during mouse spermatogenesis”. FEBS Lett 480 (2–3): 249–54. DOI:10.1016/S0014-5793(00)01942-6. PMID 11034339.

[entrez-3] 3,0 ^3,1 „Entrez Gene: RGS3 regulator of G-protein signalling 3”.

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[3]

RGS3

Reference

Literatura

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