RGS6

Regulator G-proteinske signalizacije 6
	; PDB prikaz baziran na 2es0.
Dostupne strukture
	2ES0
Identifikatori
Simboli	RGS6; GAP
Vanjski ID	OMIM: 603894 MGI: 1354730 HomoloGene: 68385 GeneCards: RGS6 Gene
Ontologija gena
Molekulska funkcija	• aktivnost prenosa signala • aktivnost GTPaznog aktivatora • proteinsko vezivanje
Ćelijska komponenta	• citoplazma • heterotrimerni G-proteinski kompleks • ćelijska membrana
Biološki proces	• signalni put G-protein spregnutog receptora • regulacija signalnog puta G-protein spregnutog receptora • intracelularni prenos signala
Pregled RNK izražavanja
	podaci
Ortolozi

edit

Regulator G-proteinske signalizacije 6 je protein koji je kod ljudi kodiran RGS6 genom.^[1]^[2]^[3]

Članovi RGS familije (regulatori G proteinske signalizacije) modulišu dejstvo G proteina putem aktivacije GTPaznih alfa podjedinica (koje vezuju nukleotid guanin).^[3]

Interactions

RGS6 formira interakcije sa STMN2^[4] and DMAP1.^[2]

Reference

↑ Seki N, Hattori A, Hayashi A, Kozuma S, Hori T, Saito T (April 1999). „The human regulator of G-protein signaling protein 6 gene (RGS6) maps between markers WI-5202 and D14S277 on chromosome 14q24.3”. J Hum Genet 44 (2): 138–40. DOI:10.1007/s100380050129. PMID 10083744.
↑ ^2,0 ^2,1 Liu Z, Fisher RA (March 2004). „RGS6 interacts with DMAP1 and DNMT1 and inhibits DMAP1 transcriptional repressor activity”. J Biol Chem 279 (14): 14120–8. DOI:10.1074/jbc.M309547200. PMID 14734556. Greška u referenci: Nevaljana oznaka <ref>; naziv "pmid14734556" je zadan više puta s različitim sadržajem
↑ ^3,0 ^3,1 „Entrez Gene: RGS6 regulator of G-protein signalling 6”.
↑ Liu, Zhengyu; Chatterjee Tapan K; Fisher Rory A (October 2002). „RGS6 interacts with SCG10 and promotes neuronal differentiation. Role of the G gamma subunit-like (GGL) domain of RGS6”. J. Biol. Chem. (United States) 277 (40): 37832–9. DOI:10.1074/jbc.M205908200. ISSN 0021-9258. PMID 12140291.

Literatura

Sherrington R, Rogaev EI, Liang Y, et al. (1995). „Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease”. Nature 375 (6534): 754–60. DOI:10.1038/375754a0. PMID 7596406.
Snow BE, Betts L, Mangion J, et al. (1999). „Fidelity of G protein β-subunit association by the G protein γ-subunit-like domains of RGS6, RGS7, and RGS11”. Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6489–94. DOI:10.1073/pnas.96.11.6489. PMC 26909. PMID 10339615.
Posner BA, Gilman AG, Harris BA (1999). „Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways”. J. Biol. Chem. 274 (43): 31087–93. DOI:10.1074/jbc.274.43.31087. PMID 10521509.
Liu Z, Chatterjee TK, Fisher RA (2002). „RGS6 interacts with SCG10 and promotes neuronal differentiation. Role of the G gamma subunit-like (GGL) domain of RGS6”. J. Biol. Chem. 277 (40): 37832–9. DOI:10.1074/jbc.M205908200. PMID 12140291.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Chatterjee TK, Fisher RA (2003). „Mild heat and proteotoxic stress promote unique subcellular trafficking and nucleolar accumulation of RGS6 and other RGS proteins. Role of the RGS domain in stress-induced trafficking of RGS proteins”. J. Biol. Chem. 278 (32): 30272–82. DOI:10.1074/jbc.M212688200. PMID 12761220.
Chatterjee TK, Liu Z, Fisher RA (2003). „Human RGS6 gene structure, complex alternative splicing, and role of N terminus and G protein gamma-subunit-like (GGL) domain in subcellular localization of RGS6 splice variants”. J. Biol. Chem. 278 (32): 30261–71. DOI:10.1074/jbc.M212687200. PMID 12761221.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039.

[pmid10083744-1] Seki N, Hattori A, Hayashi A, Kozuma S, Hori T, Saito T (April 1999). „The human regulator of G-protein signaling protein 6 gene (RGS6) maps between markers WI-5202 and D14S277 on chromosome 14q24.3”. J Hum Genet 44 (2): 138–40. DOI:10.1007/s100380050129. PMID 10083744.

[pmid14734556-2] 2,0 ^2,1 Liu Z, Fisher RA (March 2004). „RGS6 interacts with DMAP1 and DNMT1 and inhibits DMAP1 transcriptional repressor activity”. J Biol Chem 279 (14): 14120–8. DOI:10.1074/jbc.M309547200. PMID 14734556. Greška u referenci: Nevaljana oznaka <ref>; naziv "pmid14734556" je zadan više puta s različitim sadržajem

[entrez-3] 3,0 ^3,1 „Entrez Gene: RGS6 regulator of G-protein signalling 6”.

[pmid12140291-4] Liu, Zhengyu; Chatterjee Tapan K; Fisher Rory A (October 2002). „RGS6 interacts with SCG10 and promotes neuronal differentiation. Role of the G gamma subunit-like (GGL) domain of RGS6”. J. Biol. Chem. (United States) 277 (40): 37832–9. DOI:10.1074/jbc.M205908200. ISSN 0021-9258. PMID 12140291.

[1]

[2]

[3]

[4]

RGS6

Interactions

Reference

Literatura

Portal di Ensiklopedia Dunia