RGS5

Regulator G-proteinske signalizacije 5
	; PDB prikaz baziran na 2crp.
Dostupne strukture
	2CRP
Identifikatori
Simboli	RGS5; MST092; MST106; MST129; MSTP032; MSTP092; MSTP106; MSTP129
Vanjski ID	OMIM: 603276 MGI: 1098434 HomoloGene: 2682 GeneCards: RGS5 Gene
Ontologija gena
Molekulska funkcija	• aktivnost GTPaznog aktivatora
Ćelijska komponenta	• citoplazma • ćelijska membrana
Biološki proces	• transdukcija signala • regulacija signalnog puta G-protein spregnutog receptora
Pregled RNK izražavanja
	podaci
Ortolozi

edit

Regulator G-proteinske signalizacije 5 je protein koji je kod ljudi kodiran RGS5 genom.^[1]^[2]

Regulatori G proteinske signalizacije (RGS) su signal prenoseći proteini koji su strukturno homologni sa SST2 iz Saccharomyces cerevisiae i EGL-10 iz Caenorhabditis elegans. Višestruki genski homolozi proteina SST2 su prisutni kod viših eukariota. RGS proteini učestvuju u regulaciji heterotrimernih G proteina tako što deluju kao GTPazni aktivatori.^[2]

Interakcije

RGS5 formira interakcije sa GNAO1,^[3]^[4] GNAI2^[3]^[4] i GNAI3.^[3]^[4]

Reference

↑ Seki N, Sugano S, Suzuki Y, Nakagawara A, Ohira M, Muramatsu M, Saito T, Hori T (October 1998). „Isolation, tissue expression, and chromosomal assignment of human RGS5, a novel G-protein signaling regulator gene”. J Hum Genet 43 (3): 202–5. DOI:10.1007/s100380050071. PMID 9747037.
↑ ^2,0 ^2,1 „Entrez Gene: RGS5 regulator of G-protein signalling 5”.
↑ ^3,0 ^3,1 ^3,2 Chen, C; Zheng B; Han J; Lin S C (March 1997). „Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast”. J. Biol. Chem. (UNITED STATES) 272 (13): 8679–85. DOI:10.1074/jbc.272.13.8679. ISSN 0021-9258. PMID 9079700.
↑ ^4,0 ^4,1 ^4,2 Zhou, J; Moroi K; Nishiyama M; Usui H; Seki N; Ishida J; Fukamizu A; Kimura S (February 2001). „Characterization of RGS5 in regulation of G protein-coupled receptor signaling”. Life Sci. (England) 68 (13): 1457–69. DOI:10.1016/S0024-3205(01)00939-0. ISSN 0024-3205. PMID 11253162.

Literatura

Chen C, Zheng B, Han J, Lin SC (1997). „Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast”. J. Biol. Chem. 272 (13): 8679–85. DOI:10.1074/jbc.272.13.8679. PMID 9079700.
Cismowski MJ, Takesono A, Ma C, et al. (1999). „Genetic screens in yeast to identify mammalian nonreceptor modulators of G-protein signaling”. Nat. Biotechnol. 17 (9): 878–83. DOI:10.1038/12867. PMID 10471929.
Adams LD, Geary RL, McManus B, Schwartz SM (2000). „A comparison of aorta and vena cava medial message expression by cDNA array analysis identifies a set of 68 consistently differentially expressed genes, all in aortic media”. Circ. Res. 87 (7): 623–31. DOI:10.1161/01.res.87.7.623. PMID 11009569.
Hartley JL, Temple GF, Brasch MA (2001). „DNA cloning using in vitro site-specific recombination”. Genome Res. 10 (11): 1788–95. DOI:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). „Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs”. Genome Res. 11 (3): 422–35. DOI:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Zhou J, Moroi K, Nishiyama M, et al. (2001). „Characterization of RGS5 in regulation of G protein-coupled receptor signaling”. Life Sci. 68 (13): 1457–69. DOI:10.1016/S0024-3205(01)00939-0. PMID 11253162.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Morris DW, Rodgers A, McGhee KA, et al. (2005). „Confirming RGS4 as a susceptibility gene for schizophrenia”. Am. J. Med. Genet. B Neuropsychiatr. Genet. 125 (1): 50–3. DOI:10.1002/ajmg.b.20109. PMID 14755443.
Berger M, Bergers G, Arnold B, et al. (2005). „Regulator of G-protein signaling-5 induction in pericytes coincides with active vessel remodeling during neovascularization”. Blood 105 (3): 1094–101. DOI:10.1182/blood-2004-06-2315. PMID 15459006.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). „From ORFeome to biology: a functional genomics pipeline”. Genome Res. 14 (10B): 2136–44. DOI:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Liang Y, Li C, Guzman VM, et al. (2005). „Identification of a novel alternative splicing variant of RGS5 mRNA in human ocular tissues”. FEBS J. 272 (3): 791–9. DOI:10.1111/j.1742-4658.2004.04516.x. PMID 15670159.
Adams LD, Geary RL, Li J, et al. (2006). „Expression profiling identifies smooth muscle cell diversity within human intima and plaque fibrous cap: loss of RGS5 distinguishes the cap”. Arterioscler. Thromb. Vasc. Biol. 26 (2): 319–25. DOI:10.1161/01.ATV.0000196647.45718.d6. PMID 16293795.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). „Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes”. Genome Res. 16 (1): 55–65. DOI:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). „The LIFEdb database in 2006”. Nucleic Acids Res. 34 (Database issue): D415–8. DOI:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Gregory SG, Barlow KF, McLay KE, et al. (2006). „The DNA sequence and biological annotation of human chromosome 1”. Nature 441 (7091): 315–21. DOI:10.1038/nature04727. PMID 16710414.
Rhee KH, Nam KH, Lee WH, et al. (2007). „Expression, purification, and preliminary X-ray crystallographic analysis of the complex of G(alphai3)-RGS5 from human with GDP/Mg2+)/AlF4-”. Protein Pept. Lett. 13 (9): 945–9. DOI:10.2174/092986606778256225. PMID 17100651.
Bodenstein J, Sunahara RK, Neubig RR (2007). „N-terminal residues control proteasomal degradation of RGS2, RGS4, and RGS5 in human embryonic kidney 293 cells”. Mol. Pharmacol. 71 (4): 1040–50. DOI:10.1124/mol.106.029397. PMID 17220356.
Yang Z, Gaudio S, Song W, et al. (2007). „Evidence for the dimerization of human regulator of G-protein signalling 5 (RGS5)”. Cell. Physiol. Biochem. 20 (5): 303–10. DOI:10.1159/000107516. PMID 17762159.

[pmid9747037-1] Seki N, Sugano S, Suzuki Y, Nakagawara A, Ohira M, Muramatsu M, Saito T, Hori T (October 1998). „Isolation, tissue expression, and chromosomal assignment of human RGS5, a novel G-protein signaling regulator gene”. J Hum Genet 43 (3): 202–5. DOI:10.1007/s100380050071. PMID 9747037.

[entrez-2] 2,0 ^2,1 „Entrez Gene: RGS5 regulator of G-protein signalling 5”.

[pmid9079700-3] 3,0 ^3,1 ^3,2 Chen, C; Zheng B; Han J; Lin S C (March 1997). „Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast”. J. Biol. Chem. (UNITED STATES) 272 (13): 8679–85. DOI:10.1074/jbc.272.13.8679. ISSN 0021-9258. PMID 9079700.

[pmid11253162-4] 4,0 ^4,1 ^4,2 Zhou, J; Moroi K; Nishiyama M; Usui H; Seki N; Ishida J; Fukamizu A; Kimura S (February 2001). „Characterization of RGS5 in regulation of G protein-coupled receptor signaling”. Life Sci. (England) 68 (13): 1457–69. DOI:10.1016/S0024-3205(01)00939-0. ISSN 0024-3205. PMID 11253162.

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RGS5

Interakcije

Reference

Literatura

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