RGS7

Regulator G-proteinske signalizacije 7
	; PDB prikaz baziran na 2a72.
Dostupne strukture
	2A72, 2D9J
Identifikatori
Simbol	RGS7
Vanjski ID	OMIM: 602517 MGI: 1346089 HomoloGene: 2193 GeneCards: RGS7 Gene
Ontologija gena
Molekulska funkcija	• aktivnost signalnog transducera • aktivnost GTPaznog aktivatora • vezivanje G-protein beta-podjedinice
Ćelijska komponenta	• nukleus • citoplazma • citozol
Biološki proces	• signalni put G-protein spregnutog receptora • intracelularni prenos signala • terminacija signalnog puta G-protein spregnutog receptora
Pregled RNK izražavanja
	podaci
Ortolozi

edit

Regulator G-proteinske signalizacije 7 je protein koji je kod ljudi kodiran RGS7 genom.^[1]^[2]

RGS7 se nalazi u povišenoj koncentraciji u mozgu, gde deluje kao universalni inhibitor Gi/o-spregnutih GPCR. RGS7 je aktivirajući protein GTPaze (GAP). On ubrzava GTP hidrolizu na G proteinima, čime određuje njihovu brzu inaktivaciju. Isto tako deluje kao intraćeliski antagonist GPCR signalizacije.^[3]

Interacije

Pokazano je da RGS7 formira interakcije sa GPR158,^[4] PKD1,^[5] GNB5^[6]^[7] i SNAPAP.^[8]

Reference

↑ Koelle MR, Horvitz HR (Feb 1996). „EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins”. Cell 84 (1): 115–25. DOI:10.1016/S0092-8674(00)80998-8. PMID 8548815.
↑ „Entrez Gene: RGS7 regulator of G-protein signalling 7”.
↑ Anderson, Garret R.; Ekaterina Posokhova; Kirill A. Martemyanov (July 2009). „The R7 RGS Protein Family: Multi-Subunit Regulators of Neuronal G Protein Signaling”. Cell Biochemistry and Biophysics 54 (1-3): 33-46. DOI:10.1007/s12013-009-9052-9. PMID 19521673.
↑ Orlandi, Cesare; Ekaterina Posokhova; Ikuo Masuho; Thomas A. Ray; Nazarul Hasan; Ronald G. Gregg; Kirill A. Martemyanov (June 11, 2012). „GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes”. Journal of Cell Biology 197 (6): 711-719. DOI:10.1083/jcb.201202123. PMID 22689652.
↑ Kim, E; Arnould T; Sellin L; Benzing T; Comella N; Kocher O; Tsiokas L; Sukhatme V P i dr.. (May 1999). „Interaction between RGS7 and polycystin”. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (11): 6371–6. DOI:10.1073/pnas.96.11.6371. ISSN 0027-8424. PMC 26888. PMID 10339594.
↑ Levay, K; Cabrera J L; Satpaev D K; Slepak V Z (Mar 1999). „Gβ5 prevents the RGS7-Gαo interaction through binding to a distinct Gγ-like domain found in RGS7 and other RGS proteins”. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (5): 2503–7. DOI:10.1073/pnas.96.5.2503. ISSN 0027-8424. PMC 26814. PMID 10051672.
↑ Posner, B A; Gilman A G; Harris B A (Oct 1999). „Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways”. J. Biol. Chem. (UNITED STATES) 274 (43): 31087–93. DOI:10.1074/jbc.274.43.31087. ISSN 0021-9258. PMID 10521509.
↑ Hunt, Rachel A; Edris Wade; Chanda Pranab K; Nieuwenhuijsen Bart; Young Kathleen H (Apr 2003). „Snapin interacts with the N-terminus of regulator of G protein signaling 7”. Biochem. Biophys. Res. Commun. (United States) 303 (2): 594–9. DOI:10.1016/S0006-291X(03)00400-5. ISSN 0006-291X. PMID 12659861.

Literatura

Shuey DJ, Betty M, Jones PG i dr.. (1998). „RGS7 attenuates signal transduction through the G(alpha q) family of heterotrimeric G proteins in mammalian cells”. J. Neurochem. 70 (5): 1964–72. DOI:10.1046/j.1471-4159.1998.70051964.x. PMID 9572280.
Levay K, Cabrera JL, Satpaev DK, Slepak VZ (1999). „Gβ5 prevents the RGS7-Gαo interaction through binding to a distinct Gγ-like domain found in RGS7 and other RGS proteins”. Proc. Natl. Acad. Sci. U.S.A. 96 (5): 2503–7. DOI:10.1073/pnas.96.5.2503. PMC 26814. PMID 10051672.
Saitoh O, Kubo Y, Odagiri M i dr.. (1999). „RGS7 and RGS8 differentially accelerate G protein-mediated modulation of K+ currents”. J. Biol. Chem. 274 (14): 9899–904. DOI:10.1074/jbc.274.14.9899. PMID 10092682.
Kim E, Arnould T, Sellin L i dr.. (1999). „Interaction between RGS7 and polycystin”. Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6371–6. DOI:10.1073/pnas.96.11.6371. PMC 26888. PMID 10339594.
Snow BE, Betts L, Mangion J i dr.. (1999). „Fidelity of G protein β-subunit association by the G protein γ-subunit-like domains of RGS6, RGS7, and RGS11”. Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6489–94. DOI:10.1073/pnas.96.11.6489. PMC 26909. PMID 10339615.
Posner BA, Gilman AG, Harris BA (1999). „Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways”. J. Biol. Chem. 274 (43): 31087–93. DOI:10.1074/jbc.274.43.31087. PMID 10521509.
Benzing T, Yaffe MB, Arnould T i dr.. (2000). „14-3-3 interacts with regulator of G protein signaling proteins and modulates their activity”. J. Biol. Chem. 275 (36): 28167–72. DOI:10.1074/jbc.M002905200. PMID 10862767.
Rose JJ, Taylor JB, Shi J i dr.. (2000). „RGS7 is palmitoylated and exists as biochemically distinct forms”. J. Neurochem. 75 (5): 2103–12. DOI:10.1046/j.1471-4159.2000.0752103.x. PMID 11032900.
Zhang JH, Barr VA, Mo Y i dr.. (2001). „Nuclear localization of G protein beta 5 and regulator of G protein signaling 7 in neurons and brain”. J. Biol. Chem. 276 (13): 10284–9. DOI:10.1074/jbc.M009247200. PMID 11152459.
Benzing T, Köttgen M, Johnson M i dr.. (2002). „Interaction of 14-3-3 protein with regulator of G protein signaling 7 is dynamically regulated by tumor necrosis factor-alpha”. J. Biol. Chem. 277 (36): 32954–62. DOI:10.1074/jbc.M200859200. PMID 12077120.
Strausberg RL, Feingold EA, Grouse LH i dr.. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hunt RA, Edris W, Chanda PK i dr.. (2003). „Snapin interacts with the N-terminus of regulator of G protein signaling 7”. Biochem. Biophys. Res. Commun. 303 (2): 594–9. DOI:10.1016/S0006-291X(03)00400-5. PMID 12659861.
Witherow DS, Tovey SC, Wang Q i dr.. (2003). „G beta 5.RGS7 inhibits G alpha q-mediated signaling via a direct protein-protein interaction”. J. Biol. Chem. 278 (23): 21307–13. DOI:10.1074/jbc.M212884200. PMID 12670932.
Anderson NL, Polanski M, Pieper R i dr.. (2004). „The human plasma proteome: a nonredundant list developed by combination of four separate sources”. Mol. Cell Proteomics 3 (4): 311–26. DOI:10.1074/mcp.M300127-MCP200. PMID 14718574.
Takida S, Fischer CC, Wedegaertner PB (2005). „Palmitoylation and Plasma Membrane Targeting of RGS7 Are Promoted by αo”. Mol. Pharmacol. 67 (1): 132–9. DOI:10.1124/mol.104.003418. PMC 1405920. PMID 15496508.
Rual JF, Venkatesan K, Hao T i dr.. (2005). „Towards a proteome-scale map of the human protein-protein interaction network”. Nature 437 (7062): 1173–8. DOI:10.1038/nature04209. PMID 16189514.
Kimura K, Wakamatsu A, Suzuki Y i dr.. (2006). „Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes”. Genome Res. 16 (1): 55–65. DOI:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Gregory SG, Barlow KF, McLay KE i dr.. (2006). „The DNA sequence and biological annotation of human chromosome 1”. Nature 441 (7091): 315–21. DOI:10.1038/nature04727. PMID 16710414.
Drenan RM, Doupnik CA, Jayaraman M i dr.. (2006). „R7BP augments the function of RGS7*Gbeta5 complexes by a plasma membrane-targeting mechanism”. J. Biol. Chem. 281 (38): 28222–31. DOI:10.1074/jbc.M604428200. PMID 16867977.

[pmid8548815-1] Koelle MR, Horvitz HR (Feb 1996). „EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins”. Cell 84 (1): 115–25. DOI:10.1016/S0092-8674(00)80998-8. PMID 8548815.

[entrez-2] „Entrez Gene: RGS7 regulator of G-protein signalling 7”.

[3] Anderson, Garret R.; Ekaterina Posokhova; Kirill A. Martemyanov (July 2009). „The R7 RGS Protein Family: Multi-Subunit Regulators of Neuronal G Protein Signaling”. Cell Biochemistry and Biophysics 54 (1-3): 33-46. DOI:10.1007/s12013-009-9052-9. PMID 19521673.

[4] Orlandi, Cesare; Ekaterina Posokhova; Ikuo Masuho; Thomas A. Ray; Nazarul Hasan; Ronald G. Gregg; Kirill A. Martemyanov (June 11, 2012). „GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes”. Journal of Cell Biology 197 (6): 711-719. DOI:10.1083/jcb.201202123. PMID 22689652.

[pmid10339594-5] Kim, E; Arnould T; Sellin L; Benzing T; Comella N; Kocher O; Tsiokas L; Sukhatme V P i dr.. (May 1999). „Interaction between RGS7 and polycystin”. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (11): 6371–6. DOI:10.1073/pnas.96.11.6371. ISSN 0027-8424. PMC 26888. PMID 10339594.

[pmid10051672-6] Levay, K; Cabrera J L; Satpaev D K; Slepak V Z (Mar 1999). „Gβ5 prevents the RGS7-Gαo interaction through binding to a distinct Gγ-like domain found in RGS7 and other RGS proteins”. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (5): 2503–7. DOI:10.1073/pnas.96.5.2503. ISSN 0027-8424. PMC 26814. PMID 10051672.

[pmid10521509-7] Posner, B A; Gilman A G; Harris B A (Oct 1999). „Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways”. J. Biol. Chem. (UNITED STATES) 274 (43): 31087–93. DOI:10.1074/jbc.274.43.31087. ISSN 0021-9258. PMID 10521509.

[pmid12659861-8] Hunt, Rachel A; Edris Wade; Chanda Pranab K; Nieuwenhuijsen Bart; Young Kathleen H (Apr 2003). „Snapin interacts with the N-terminus of regulator of G protein signaling 7”. Biochem. Biophys. Res. Commun. (United States) 303 (2): 594–9. DOI:10.1016/S0006-291X(03)00400-5. ISSN 0006-291X. PMID 12659861.

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RGS7

Interacije

Reference

Literatura

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