RGS20

Regulator G-proteinske signalizacije 20
Identifikatori
Simboli	RGS20; RGSZ1; ZGAP1; g(z)GAP; gz-GAP
Vanjski ID	OMIM: 607193 MGI: 1929866 HomoloGene: 2745 GeneCards: RGS20 Gene
Ontologija gena
Molekulska funkcija	• aktivnost GTPaznog aktivatora • proteinsko vezivanje
Ćelijska komponenta	• nukleus • citoplazma • ćelijska membrana
Biološki proces	• regulacija signalnog puta G-protein spregnutog receptora • termination signalnog puta G-protein spregnutog receptora • pozitivna regulacija GTPazne aktivnosti
Pregled RNK izražavanja
	podaci
Ortolozi

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Regulator G-proteinske signalizacije 20 je protein koji je kod ljudi kodiran RGS20 genom.^[1]^[2]^[3]

Regulatori G proteinske signalizacije (RGS) su regulatorne i strukturne komponente G protein-spregnutih receptorskih kompleksa. RGS proteini su GTPazni aktivatori za Gi (GNAI1; MIM 139310) i Gq (GNAQ; MIM 600998) klasu G-alfa proteina. Oni ubrzavaju tranzit kroz ciklus GTP vezivanja i hidrolize i tim putem ubrzavaju signalizacionu kinetiku i terminaciju.^[3]

Interakcije

RGS20 formira interakcije sa GNAO1^[4] i GNAZ.^[1]^[5]

Reference

↑ ^1,0 ^1,1 Glick JL, Meigs TE, Miron A, Casey PJ (Nov 1998). „RGSZ1, a Gz-selective regulator of G protein signaling whose action is sensitive to the phosphorylation state of Gzalpha”. J Biol Chem 273 (40): 26008–13. DOI:10.1074/jbc.273.40.26008. PMID 9748279. Greška u referenci: Nevaljana oznaka <ref>; naziv "pmid9748279" je zadan više puta s različitim sadržajem
↑ Wang J, Ducret A, Tu Y, Kozasa T, Aebersold R, Ross EM (Nov 1998). „RGSZ1, a Gz-selective RGS protein in brain. Structure, membrane association, regulation by Galphaz phosphorylation, and relationship to a Gz gtpase-activating protein subfamily”. J Biol Chem 273 (40): 26014–25. DOI:10.1074/jbc.273.40.26014. PMID 9748280.
↑ ^3,0 ^3,1 „Entrez Gene: RGS20 regulator of G-protein signalling 20”.
↑ Pagano, Mario; Jordan J Dedrick; Neves Susana R; Nguyen Tracy; Iyengar Ravi (Jun 2008). „Galphao/i-stimulated proteosomal degradation of RGS20: a mechanism for temporal integration of Gs and Gi pathways”. Cell. Signal. (England) 20 (6): 1190–7. DOI:10.1016/j.cellsig.2008.02.008. ISSN 0898-6568. PMC 3107604. PMID 18407463.
↑ Nagahama, Masami; Usui Shihomi; Shinohara Takashi; Yamaguchi Tomohiro; Tani Katsuko; Tagaya Mitsuo (Dec 2002). „Inactivation of Galpha(z) causes disassembly of the Golgi apparatus”. J. Cell. Sci. (England) 115 (Pt 23): 4483–93. DOI:10.1242/jcs.00093. ISSN 0021-9533. PMID 12414994.

Literatura

Barker SA, Wang J, Sierra DA, Ross EM (2002). „RGSZ1 and Ret RGS: two of several splice variants from the gene RGS20.”. Genomics 78 (3): 223–9. DOI:10.1006/geno.2001.6659. PMID 11735229.
Sierra DA, Gilbert DJ, Householder D, et al. (2002). „Evolution of the regulators of G-protein signaling multigene family in mouse and human.”. Genomics 79 (2): 177–85. DOI:10.1006/geno.2002.6693. PMID 11829488.
Nixon AB, Grenningloh G, Casey PJ (2002). „The interaction of RGSZ1 with SCG10 attenuates the ability of SCG10 to promote microtubule disassembly.”. J. Biol. Chem. 277 (20): 18127–33. DOI:10.1074/jbc.M201065200. PMID 11882662.
Wang Y, Ho G, Zhang JJ, et al. (2003). „Regulator of G protein signaling Z1 (RGSZ1) interacts with Galpha i subunits and regulates Galpha i-mediated cell signaling.”. J. Biol. Chem. 277 (50): 48325–32. DOI:10.1074/jbc.M206116200. PMID 12379657.
Nagahama M, Usui S, Shinohara T, et al. (2003). „Inactivation of Galpha(z) causes disassembly of the Golgi apparatus.”. J. Cell. Sci. 115 (Pt 23): 4483–93. DOI:10.1242/jcs.00093. PMID 12414994.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Fischer T, De Vries L, Meerloo T, Farquhar MG (2003). „Promotion of G alpha i3 subunit down-regulation by GIPN, a putative E3 ubiquitin ligase that interacts with RGS-GAIP.”. Proc. Natl. Acad. Sci. U.S.A. 100 (14): 8270–5. DOI:10.1073/pnas.1432965100. PMC 166218. PMID 12826607.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs.”. Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039.
Xu GY, Hum WT, Sukits SF, et al. (2004). „1H, 13C and 15N resonance assignments of human RGSZ1.”. J. Biomol. NMR 28 (4): 409–10. DOI:10.1023/B:JNMR.0000015374.29659.f9. PMID 14872136.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). „Towards a proteome-scale map of the human protein-protein interaction network.”. Nature 437 (7062): 1173–8. DOI:10.1038/nature04209. PMID 16189514.
Ajit SK, Ramineni S, Edris W, et al. (2007). „RGSZ1 interacts with protein kinase C interacting protein PKCI-1 and modulates mu opioid receptor signaling.”. Cell. Signal. 19 (4): 723–30. DOI:10.1016/j.cellsig.2006.09.008. PMID 17126529.
Ewing RM, Chu P, Elisma F, et al. (2007). „Large-scale mapping of human protein-protein interactions by mass spectrometry.”. Mol. Syst. Biol. 3 (1): 89. DOI:10.1038/msb4100134. PMC 1847948. PMID 17353931.

[pmid9748279-1] 1,0 ^1,1 Glick JL, Meigs TE, Miron A, Casey PJ (Nov 1998). „RGSZ1, a Gz-selective regulator of G protein signaling whose action is sensitive to the phosphorylation state of Gzalpha”. J Biol Chem 273 (40): 26008–13. DOI:10.1074/jbc.273.40.26008. PMID 9748279. Greška u referenci: Nevaljana oznaka <ref>; naziv "pmid9748279" je zadan više puta s različitim sadržajem

[pmid9748280-2] Wang J, Ducret A, Tu Y, Kozasa T, Aebersold R, Ross EM (Nov 1998). „RGSZ1, a Gz-selective RGS protein in brain. Structure, membrane association, regulation by Galphaz phosphorylation, and relationship to a Gz gtpase-activating protein subfamily”. J Biol Chem 273 (40): 26014–25. DOI:10.1074/jbc.273.40.26014. PMID 9748280.

[entrez-3] 3,0 ^3,1 „Entrez Gene: RGS20 regulator of G-protein signalling 20”.

[pmid18407463-4] Pagano, Mario; Jordan J Dedrick; Neves Susana R; Nguyen Tracy; Iyengar Ravi (Jun 2008). „Galphao/i-stimulated proteosomal degradation of RGS20: a mechanism for temporal integration of Gs and Gi pathways”. Cell. Signal. (England) 20 (6): 1190–7. DOI:10.1016/j.cellsig.2008.02.008. ISSN 0898-6568. PMC 3107604. PMID 18407463.

[pmid12414994-5] Nagahama, Masami; Usui Shihomi; Shinohara Takashi; Yamaguchi Tomohiro; Tani Katsuko; Tagaya Mitsuo (Dec 2002). „Inactivation of Galpha(z) causes disassembly of the Golgi apparatus”. J. Cell. Sci. (England) 115 (Pt 23): 4483–93. DOI:10.1242/jcs.00093. ISSN 0021-9533. PMID 12414994.

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RGS20

Interakcije

Reference

Literatura

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