Fludiazepam

Fludiazepam
Alerta sobre risco à saúde
Nome IUPAC 7-chloro-5-(2-fluorophenyl)-1-methyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one
Identificadores
Número CAS 3900-31-0
PubChem 3369
DrugBank DB01567
ChemSpider 3252
ChEBI 31618
Código ATC N05BA17
SMILES
Primeiro nome comercial ou de referência Erispan (Japão, Taiwan)
Propriedades
Fórmula química C16H12ClFN2O
Massa molar 302.73 g mol-1
Farmacologia
Metabolismo ​​Hepático
Excreção Renal
Página de dados suplementares
Estrutura e propriedades n, εr, etc.
Dados termodinâmicos Phase behaviour
Solid, liquid, gas
Dados espectrais UV, IV, RMN, EM
Exceto onde denotado, os dados referem-se a
materiais sob condições normais de temperatura e pressão

Referências e avisos gerais sobre esta caixa.
Alerta sobre risco à saúde.

Fludiazepam,[1] comercializado sob o nome de Erispan (エリスパン)[2][3] é uma benzodiazepina potente derivada do 2ʹ-fluoro do diazepam,[4] originalmente desenvolvido por Hoffman-La Roche na década de 1960.[5] É comercializado no Japão e em Taiwan. Ele exerce suas propriedades farmacológicas através do aumento da inibição GABAérgica.[6] O fludiazepam tem 4 vezes mais afinidade de ligação com os receptores GABA que o diazepam.[7] Possui propriedades ansiolíticas,[8][9][10] anticonvulsivantes, sedativas, hipnóticas e relaxantes musculoesqueléticas.[11] O fludiazepam tem sido usado recreacionalmente.[12]

Ver também

Referências

  1. US Patent 3371085 5-aryl-3h-1,4-benzodiazepin-2(1h)-ones
  2. Su TP, Chen TJ, Hwang SJ, Chou LF, Fan AP, Chen YC. «Utilization of psychotropic drugs in Taiwan: an overview of outpatient sector in 2000». Zhonghua Yi Xue Za Zhi (Chinese Medical Journal; Free China ed). 65: 378–91. PMID 12455808 
  3. «Benzodiazepine Names». non-benzodiazepines.org.uk. Consultado em 29 de dezembro de 2008. Cópia arquivada em 8 de dezembro de 2008 
  4. Neville GA, Beckstead HD, Shurvell HF. «A Fourier transform-Raman and infrared vibrational study of delorazepam, fludiazepam, flurazepam, and tetrazepam». Journal of Pharmaceutical Sciences. 83: 143–51. PMID 7909552. doi:10.1002/jps.2600830207 
  5. US Patent 3299053 -ARYL-JH-L,X-BENZODIAZEPIN-Z(LH)-ONES
  6. Tsuchiya T, Fukushima H. «Effects of benzodiazepines and pentobarbitone on the gaba-ergic recurrent inhibition of hippocampal neurons». European Journal of Pharmacology. 48: 421–4. PMID 648585. doi:10.1016/0014-2999(78)90169-3 
  7. Nakatsuka I, Shimizu H, Asami Y, Katoh T, Hirose A, Yoshitake A. «Benzodiazepines and their metabolites: relationship between binding affinity to the benzodiazepine receptor and pharmacological activity». Life Sciences. 36: 113–9. PMID 2857046. doi:10.1016/0024-3205(85)90089-X 
  8. Okada S, Ichiki K, Tanokuchi S, Ishii K, Hamada H, Ota Z (1994). «Effect of an anxiolytic on lipid profile in non-insulin-dependent diabetes mellitus». The Journal of International Medical Research. 22: 338–42. PMID 7895897. doi:10.1177/030006059402200605 
  9. Okada S, Ichiki K, Tanokuchi S, Ishii K, Hamada H, Ota Z (1995). «Improvement of stress reduces glycosylated haemoglobin levels in patients with type 2 diabetes». The Journal of International Medical Research. 23: 119–22. PMID 7601294. doi:10.1177/030006059502300205 
  10. Okada S, Ichiki K, Tanokuchi S, Ishii K, Hamada H, Ota Z (1995). «How blood pressure in patients with non-insulin-dependent diabetes mellitus is influenced by stress». The Journal of International Medical Research. 23: 377–80. PMID 8529781. doi:10.1177/030006059502300508 
  11. Inoue H, Maeno Y, Iwasa M, Matoba R, Nagao M. «Screening and determination of benzodiazepines in whole blood using solid-phase extraction and gas chromatography/mass spectrometry». Forensic Science International. 113: 367–73. PMID 10978650. doi:10.1016/S0379-0738(00)00226-7 
  12. Shimamine M, Masunari T, Nakahara Y (1993). «[Studies on identification of drugs of abuse by diode array detection. I. Screening-test and identification of benzodiazepines by HPLC-DAD with ICOS software system]». Eisei Shikenjo Hokoku. Bulletin of National Institute of Hygienic Sciences: 47–56. PMID 7920567 
Ícone de esboço Este artigo sobre fármacos é um esboço. Você pode ajudar a Wikipédia expandindo-o.

Read other articles:

I Saw the LightTheatrical release posterSutradaraMarc AbrahamProduser Marc Abraham Aaron L. Gilbert Brett Ratner G. Marq Roswell Ditulis olehMarc AbrahamBerdasarkanHank Williams: The Biographyoleh Colin EscottGeorge MerrittWilliam MacEwenPemeran Tom Hiddleston Elizabeth Olsen Cherry Jones Bradley Whitford Maddie Hasson Wrenn Schmidt Penata musikAaron ZigmanSinematograferDante SpinottiPenyuntingAlan HeimPerusahaanproduksi Bron Studios CW Media Finance RatPac Entertainment DistributorSony...

 

Raden AdipatiWira Tanu Datar IV [[Bupati Cianjur]] 4Masa jabatan1727–1761Wakil PresidenWira Nata PendahuluR.A. Wira Tanu IIIPenggantiR.A. Wira Tanu Datar V Informasi pribadiLahirCianjurMeninggalCianjurProfesiBangsawan, UlamaSunting kotak info • L • B Raden Adipati Wira Tanu Datar IV adalah bupati Cianjur keempat yang memerintah pada tahun 1727 s.d. 1761 Kehidupan Awal Raden Adipati Wira Tanu Datar IV nama aslinya adalah Raden Sabirudin. Penetapan Raden Sabirudin sebagai re...

 

العلاقات الزيمبابوية الشمال مقدونية زيمبابوي شمال مقدونيا   زيمبابوي   شمال مقدونيا تعديل مصدري - تعديل   العلاقات الزيمبابوية الشمال مقدونية هي العلاقات الثنائية التي تجمع بين زيمبابوي وشمال مقدونيا.[1][2][3][4][5] مقارنة بين البلدين هذه مقا�...

American professional wrestler and YouTuber (born 1995) Logan PaulPaul in 2019BornLogan Alexander Paul (1995-04-01) April 1, 1995 (age 29)Westlake, Ohio, U.S.Occupations Media/online personality Influencer actor professional wrestler RelativesJake Paul (brother)YouTube informationChannels Logan Paul Impaulsive Years active2007–presentGenres Comedy vlog Subscribers 23.5 million Total views 5.9 billion Creator Awards100,000 subscribers20161,000,000 subscribers201610,000,000 sub...

 

LGBT rights in IdahoIdaho (US)StatusLegal since 2003; codified 2022(Lawrence v. Texas)Gender identityCase law in the state requires the state to change birth certificates for transgender peopleDiscrimination protectionsProtections in employment; some municipalities have passed further protectionsFamily rightsRecognition of relationshipsSame-sex marriage since 2014AdoptionSame-sex couples may adopt jointly Lesbian, gay, bisexual and transgender (LGBT) people in the U.S. state of Idaho face so...

 

Pour les articles homonymes, voir Robert Robinson (basket-ball) et Robinson. Robert RobinsonRobert Robinson.FonctionPrésident de la Royal Society1945-1950Henry Hallett DaleEdgar Douglas AdrianBiographieNaissance 13 septembre 1886Rufford (en)Décès 8 février 1975 (à 88 ans)Great MissendenSépulture Cimetière de Kensal GreenNationalité britanniqueFormation Université de Manchester (doctorat ès sciences) (jusqu'en 1910)Fulneck School (en)Brookfield Community School (en)Activité Ch...

School in AustraliaNewcastle High SchoolLocation160–200 Parkway Avenue, Hamilton South,Hunter Region, New South WalesAustraliaCoordinates32°55′56″S 151°45′28″E / 32.9322°S 151.7578°E / -32.9322; 151.7578InformationFormer nameNewcastle Girls' High SchoolTypeGovernment-funded co-educational comprehensive secondary day schoolMottoLatin: Remis Velisque(With Oars and Sails; with all one's might[1][2])Established1929; 95 years ago&...

 

Untuk kegunaan lain, lihat Romanesque (disambiguasi). Ukiran dari Biara Maria Laach, di Eifel, Rhineland. Seni rupa Romanesque adalah sebuah seni rupa di Eropa dari sekitar 1000 Masehi sampai berkembangnya gaya Gothik pada abad ke-13, atau kemudian, tergantung pada wilayahnya. Periode sebelumnya dikenal sebagai periode Pra-Romanesque. Istilah tersebut dicetuskan oleh para sejarawan seni rupa abad ke-19, khususnya untuk arsitektur Romanesque, yang masih menampilkan beberapa dasar gaya arsitekt...

 

Pour les articles homonymes, voir Boulard. Geoffroy Boulard Fonctions Maire du 17e arrondissement de Paris En fonction depuis le 11 juillet 2017(6 ans, 9 mois et 28 jours) Réélection 28 juin 2020 Prédécesseur Brigitte Kuster Vice-président de la Métropoledu Grand Paris En fonction depuis le 20 juillet 2020(3 ans, 9 mois et 19 jours) Élection 20 juillet 2020 Président Patrick Ollier Conseiller de Paris En fonction depuis le 30 mars 2014(10 ans, ...

此条目序言章节没有充分总结全文内容要点。 (2019年3月21日)请考虑扩充序言,清晰概述条目所有重點。请在条目的讨论页讨论此问题。 哈萨克斯坦總統哈薩克總統旗現任Қасым-Жомарт Кемелұлы Тоқаев卡瑟姆若马尔特·托卡耶夫自2019年3月20日在任任期7年首任努尔苏丹·纳扎尔巴耶夫设立1990年4月24日(哈薩克蘇維埃社會主義共和國總統) 哈萨克斯坦 哈萨克斯坦政府...

 

One of the four major ancient Greek tribes For the rugby union club, see Hull Ionians. Ἴων redirects here. For the dialogue, see Ion (dialogue). Ionian soldier (Old Persian cuneiform 𐎹𐎢𐎴, Yaunā)[1] of the Achaemenid army, circa 480 BCE. Xerxes I tomb relief. Part of a series on the History of Greece Neolithic Greece Pelasgians Greek Bronze Age Helladic Cycladic Minoan Mycenaean Greece 1750 BC–1050 BC Ancient Greece Greek Dark Ages 1050 BC–750 BC Archaic Greece 800 BC...

 

Rancho Ex-Mission San Fernando was a 116,858-acre (472.91 km2) Mexican land grant in present-day Los Angeles County, California, granted in 1846 by Governor Pío Pico to Eulogio F. de Celis.[1] The grant derives its name from the secularized Mission San Fernando Rey de España, but was called ex-Mission because of a division made of the lands held in the name of the mission—the church retaining the grounds immediately around, and all of the lands outside of this were called ex-...

بانكوك في خطرBangkok Dangerous (بالإنجليزية) معلومات عامةالصنف الفني حركة، جريمة، إثارةتاريخ الصدور 2008مدة العرض 100 دقيقةاللغة الأصلية الإنجليزيةالعرض أبيض وأسود مأخوذ عن Bangkok Dangerous (en) البلد الولايات المتحدةمواقع التصوير جمهورية التشيك — تايلاند موقع الويب bangkokdangerousmovie.net الطاقما...

 

Peacekeeping Operation by United Nation Organisation For the specific UN missions to Haiti, see MINUSTAH and MINUJUSTH. The United Nations Mission in Haiti (UNMIH) was a peacekeeping operation carried out by the United Nations between September 1993 and June 1996. The Mission was reestablished (MINUSTAH) in April 2004, after a rebellion took over most of Haiti and President Bertrand Aristide resigned.[1] This mandate ended in 2017, replaced by United Nations Mission for Justice Suppor...

 

1985 story collection by Samuel R. Delany This article includes a list of references, related reading, or external links, but its sources remain unclear because it lacks inline citations. Please help improve this article by introducing more precise citations. (September 2023) (Learn how and when to remove this message) Flight from Nevèrÿon Cover from the first editionAuthorSamuel R. DelanyCover artistRowena MorrillLanguageEnglishSeriesReturn to NevèrÿonGenreSword and SorceryPublisher...

Renania Settentrionale-Vestfalialand(DE) Land Nordrhein-Westfalen LocalizzazioneStato Germania AmministrazioneCapoluogoDüsseldorf Ministro presidenteHendrik Wüst (CDU) dal 27 ottobre 2021 TerritorioCoordinatedel capoluogo51°28′N 7°33′E51°28′N, 7°33′E (Renania Settentrionale-Vestfalia) Altitudine45 m s.l.m. Superficie34 112,52 km² Abitanti17 924 591[1] (31-12-2021) Densità525,45 ab./km² Distretti gov.5 distretti governat...

 

Questa voce sull'argomento stagioni delle società calcistiche italiane è solo un abbozzo. Contribuisci a migliorarla secondo le convenzioni di Wikipedia. Segui i suggerimenti del progetto di riferimento. Voce principale: Associazione Sportiva Lucchese Libertas 1905. Unione Sportiva Lucchese LibertasStagione 1975-1976Sport calcio Squadra Lucchese Allenatore Tito Corsi Presidente Vasco Vannucchi Serie C5º posto nel girone B. Maggiori presenzeCampionato: Stanzial (38) Miglior marca...

 

Chinese general (1913-1985) Liang XingchuLiang Xingchu in 1955Native name梁兴初Born(1913-08-23)August 23, 1913Ji'an County, Jiangxi, ChinaDiedOctober 5, 1985(1985-10-05) (aged 72)Beijing, ChinaAllegiance People's Republic of ChinaRankLieutenant generalCommandsChengdu Military RegionBattles/warsChinese Civil WarSecond Sino-Japanese WarKorean WarAwardsOrder of Bayi (Second Class)Order of Independence and Freedom (First Class)Order of Liberation (First Class) Liang Xingchu (Chinese&...

ملوك آشور أزراح ملوك آشور معلومات شخصية تعديل مصدري - تعديل   أزراح، أو آ-زا-را-آح، كان الملك الأشوري من الفترة المبكرة وفقا لقائمة ملوك آشور الذي ذكر فيها أنه الخامس عشر من أصل سبعة عشر ملكا مِن مَن عاشوا في الخيم.[1][2] وكثيرا ما تم تفسيره على أنها قائمة أسلاف الملك...

 

جرانيتاملصق الفيلممعلومات عامةالصنف الفني دراما ، رومانسيتاريخ الصدور 2001مدة العرض 100 دقيقةاللغة الأصلية العربيةالبلد  مصرالطاقمالمخرج عمر عبدالعزيز (مخرج) عمر الشيخ (مخرج مساعد) نشأت عبداللطيف (مخرج مساعد)الحوار ناصر عبدالرحمنالسيناريو ناصر عبدالرحمنالموسيقى عزت ال�...