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WEE1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1X8B, 2IN6, 2IO6, 2Z2W, 3BI6, 3BIZ, 3CQE, 3CR0
Identifiers
Aliases	WEE1, WEE1A, WEE1hu, WEE1 G2 checkpoint kinase
External IDs	OMIM: 193525; MGI: 103075; HomoloGene: 31152; GeneCards: WEE1; OMA:WEE1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	9,593,457 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	109,742,493 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; skin of thigh; ; mucosa of paranasal sinus; ; tail of epididymis; ; gastric mucosa; ; buccal mucosa cell; ; embryo; ; ganglionic eminence; ; bronchial epithelial cell; ; skin of abdomen;
	Top expressed in
	decidua; ; gastrula; ; primitive streak; ; cumulus cell; ; parotid gland; ; endocardial cushion; ; vas deferens; ; pontine nuclei; ; maxillary prominence; ; mandibular prominence;
	More reference expression data
	n/a
Gene ontology
Molecular function	metal ion binding; nucleotide binding; protein tyrosine kinase activity; protein kinase activity; transferase activity; magnesium ion binding; non-membrane spanning protein tyrosine kinase activity; ATP binding; protein binding; kinase activity;
Cellular component	nucleolus; nucleoplasm; cytoplasm; nucleus;
Biological process	cell cycle; neuron projection morphogenesis; establishment of cell polarity; cell division; G2/M transition of mitotic cell cycle; microtubule cytoskeleton organization; peptidyl-tyrosine phosphorylation; protein phosphorylation; phosphorylation; mitotic cell cycle; G1/S transition of mitotic cell cycle; negative regulation of G1/S transition of mitotic cell cycle; mitotic cell cycle checkpoint signaling;
	Sources:Amigo / QuickGO
Orthologs
	7465
	22390
	ENSG00000166483
	ENSMUSG00000031016
	P30291
	P47810
	NM_001143976; NM_003390
	NM_009516; NM_001355058
	NP_001137448; NP_003381
	NP_033542; NP_001341987
	Wikidata
View/Edit Human	View/Edit Mouse

WEE1 homolog (S. pombe), also known as WEE1, is a protein which in humans is encoded by the WEE1 gene.^[5]

Function

This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase.^[6]

Interactions

Wee1-like protein kinase has been shown to interact with YWHAB^[7] and PIN1.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000166483 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031016 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Igarashi M, Nagata A, Jinno S, Suto K, Okayama H (September 1991). "Wee1(+)-like gene in human cells". Nature. 353 (6339): 80–3. Bibcode:1991Natur.353...80I. doi:10.1038/353080a0. PMID 1840647. S2CID 2920330.
^ "Entrez Gene: WEE1 WEE1 homolog (S. pombe)".
^ Wang, Y; Jacobs C; Hook K E; Duan H; Booher R N; Sun Y (April 2000). "Binding of 14-3-3beta to the carboxyl terminus of Wee1 increases Wee1 stability, kinase activity, and G2-M cell population". Cell Growth Differ. 11 (4). UNITED STATES: 211–9. ISSN 1044-9523. PMID 10775038.
^ Shen, M; Stukenberg P T; Kirschner M W; Lu K P (March 1998). "The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins". Genes Dev. 12 (5). UNITED STATES: 706–20. doi:10.1101/gad.12.5.706. ISSN 0890-9369. PMC 316589. PMID 9499405.