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PRKCD
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2YUU, 1YRK
Identifiers
Aliases	PRKCD, ALPS3, CVID9, MAY1, PKCD, nPKC-delta, protein kinase C delta
External IDs	OMIM: 176977; MGI: 97598; HomoloGene: 55963; GeneCards: PRKCD; OMA:PRKCD - orthologs
EC number	2.7.10.2
Gene location (Human)
Chr.	Chromosome 3 (human)
End	53,192,717 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	30,348,167 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; right adrenal cortex; ; right uterine tube; ; mucosa of transverse colon; ; left adrenal gland; ; left adrenal cortex; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; rectum;
	Top expressed in
	lateral geniculate nucleus; ; granulocyte; ; medial dorsal nucleus; ; medial geniculate nucleus; ; lateral septal nucleus; ; pyloric antrum; ; seminiferous tubule; ; epithelium of stomach; ; large intestine; ; colon;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	kinase activity; ATP binding; protein kinase activity; non-membrane spanning protein tyrosine kinase activity; metal ion binding; kinase binding; enzyme binding; insulin receptor substrate binding; transferase activity; protein binding; calcium-independent protein kinase C activity; protein kinase binding; nucleotide binding; enzyme activator activity; protein serine/threonine kinase activity; protein kinase C activity;
Cellular component	cytoplasm; cytosol; membrane; cell-cell junction; perinuclear region of cytoplasm; nucleus; nuclear matrix; endoplasmic reticulum; extracellular exosome; plasma membrane; nucleoplasm; extracellular region; azurophil granule lumen;
Biological process	intrinsic apoptotic signaling pathway in response to oxidative stress; termination of signal transduction; interferon-gamma-mediated signaling pathway; negative regulation of protein binding; positive regulation of endodeoxyribonuclease activity; platelet activation; protein phosphorylation; cellular senescence; negative regulation of insulin receptor signaling pathway; positive regulation of sphingomyelin catabolic process; cell chemotaxis; cell cycle; negative regulation of inflammatory response; positive regulation of protein dephosphorylation; Fc-gamma receptor signaling pathway involved in phagocytosis; positive regulation of apoptotic signaling pathway; stimulatory C-type lectin receptor signaling pathway; cellular response to hydroperoxide; negative regulation of peptidyl-tyrosine phosphorylation; defense response to bacterium; negative regulation of MAP kinase activity; positive regulation of response to DNA damage stimulus; positive regulation of protein import into nucleus; interleukin-10 production; regulation of actin cytoskeleton organization; negative regulation of actin filament polymerization; regulation of mRNA stability; phosphorylation; protein stabilization; regulation of signaling receptor activity; negative regulation of filopodium assembly; cellular response to angiotensin; interleukin-12 production; peptidyl-threonine phosphorylation; positive regulation of ceramide biosynthetic process; neutrophil activation; intracellular signal transduction; negative regulation of glial cell apoptotic process; negative regulation of platelet aggregation; positive regulation of phospholipid scramblase activity; B cell proliferation; immunoglobulin mediated immune response; positive regulation of glucosylceramide catabolic process; peptidyl-tyrosine phosphorylation; positive regulation of superoxide anion generation; activation of protein kinase activity; signal transduction; cellular response to hydrogen peroxide; peptidyl-serine phosphorylation; apoptotic process; neutrophil degranulation; execution phase of apoptosis;
	Sources:Amigo / QuickGO
Orthologs
	5580
	18753
	ENSG00000163932
	ENSMUSG00000021948
	Q05655
	P28867
NM_006254; NM_212539; NM_001316327; NM_001354676; NM_001354678;
	NM_001354679; NM_001354680
	NM_011103; NM_001310682
NP_001303256; NP_006245; NP_997704; NP_001341605; NP_001341607;
	NP_001341608; NP_001341609
	NP_001297611; NP_035233
	Wikidata
View/Edit Human	View/Edit Mouse

Protein kinase C delta type (or PKC-δ) is an enzyme that in humans is encoded by the PRKCD gene.^[5]

Function

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by the second messenger diacylglycerol.^[6] PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types.^[7] Protein kinase C delta is also regulated by phosphorylation on various serine/threonine (e.g. T50, T141, S304, T451, T505, S506, T507, S643, S664) and tyrosine residues including Y311 (by SRC).^[8]^[9]