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CAMK4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2W4O
Identifiers
Aliases	CAMK4, CaMK IV, CaMK-GR, IV, caMK, calcium/calmodulin-dependent protein kinase IV, calcium/calmodulin dependent protein kinase IV, CaMKIV
External IDs	OMIM: 114080; MGI: 88258; HomoloGene: 100780; GeneCards: CAMK4; OMA:CAMK4 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	111,494,886 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	33,324,281 bp
RNA expression pattern
	Top expressed in
	cerebellar vermis; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; middle temporal gyrus; ; left testis; ; right testis; ; paraflocculus of cerebellum; ; ganglionic eminence; ; nucleus accumbens; ; superior frontal gyrus;
	Top expressed in
	cerebellar cortex; ; superior frontal gyrus; ; thymus; ; primary visual cortex; ; lobe of cerebellum; ; seminiferous tubule; ; dentate gyrus of hippocampal formation granule cell; ; cerebellar vermis; ; spermatid; ; olfactory tubercle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; calcium-dependent protein serine/threonine kinase activity; calmodulin binding; kinase activity; protein serine/threonine kinase activity; calmodulin-dependent protein kinase activity; ATP binding;
Cellular component	cytoplasm; cytosol; nucleoplasm; extracellular exosome; nucleus; fibrillar center; postsynapse; glutamatergic synapse;
Biological process	intracellular signal transduction; adaptive immune response; myeloid dendritic cell cytokine production; phosphorylation; immune system process; myeloid dendritic cell differentiation; positive regulation of transcription, DNA-templated; regulation of T cell differentiation in thymus; protein phosphorylation; regulation of osteoclast differentiation; long-term memory; peptidyl-serine phosphorylation; protein autophosphorylation; inflammatory response; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	814
	12326
	ENSG00000152495
	ENSMUSG00000038128
	Q16566
	P08414; Q8BGR3
	NM_001744; NM_001323374; NM_001323375; NM_001323376; NM_001323377
	NM_009793
	NP_001310303; NP_001310304; NP_001310305; NP_001310306; NP_001735
	NP_033923
	Wikidata
View/Edit Human	View/Edit Mouse

Calcium/calmodulin-dependent protein kinase type IV is an enzyme that in humans is encoded by the CAMK4 gene.^[5]

The product of this gene belongs to the serine/threonine protein kinase cluster, and to the Ca²⁺/calmodulin-dependent protein kinase (CAMK) group. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons, and male germ cells.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000152495 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038128 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sikela JM, Law ML, Kao FT, Hartz JA, Wei Q, Hahn WE (Mar 1989). "Chromosomal localization of the human gene for brain Ca²⁺/calmodulin-dependent protein kinase type IV". Genomics. 4 (1): 21–7. doi:10.1016/0888-7543(89)90309-1. PMID 2536634.
^ "Entrez Gene: CAMK4 calcium/calmodulin-dependent protein kinase IV".

Bredt DS, Ferris CD, Snyder SH (1992). "Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites". J. Biol. Chem. 267 (16): 10976–81. doi:10.1016/S0021-9258(19)49862-1. PMID 1375933.
Jensen KF, Ohmstede CA, Fisher RS, Sahyoun N (1991). "Nuclear and axonal localization of Ca²⁺/calmodulin-dependent protein kinase type Gr in rat cerebellar cortex". Proc. Natl. Acad. Sci. U.S.A. 88 (7): 2850–3. Bibcode:1991PNAS...88.2850J. doi:10.1073/pnas.88.7.2850. PMC 51337. PMID 2011593.
Selbert MA, Anderson KA, Huang QH, et al. (1995). "Phosphorylation and activation of Ca²⁺-calmodulin-dependent protein kinase IV by Ca²⁺-calmodulin-dependent protein kinase Ia kinase. Phosphorylation of threonine 196 is essential for activation". J. Biol. Chem. 270 (29): 17616–21. doi:10.1074/jbc.270.29.17616. PMID 7615569.
Kitani T, Okuno S, Fujisawa H (1994). "cDNA cloning and expression of human calmodulin-dependent protein kinase IV". J. Biochem. 115 (4): 637–40. doi:10.1093/oxfordjournals.jbchem.a124387. PMID 8089075.
Mosialos G, Hanissian SH, Jawahar S, et al. (1994). "A Ca²⁺/calmodulin-dependent protein kinase, CaM kinase-Gr, expressed after transformation of primary human B lymphocytes by Epstein-Barr virus (EBV) is induced by the EBV oncogene LMP1". J. Virol. 68 (3): 1697–705. doi:10.1128/JVI.68.3.1697-1705.1994. PMC 236629. PMID 8107230.
Bland MM, Monroe RS, Ohmstede CA (1994). "The cDNA sequence and characterization of the Ca²⁺/calmodulin-dependent protein kinase-Gr from human brain and thymus". Gene. 142 (2): 191–7. doi:10.1016/0378-1119(94)90260-7. PMID 8194751.
Tokumitsu H, Soderling TR (1996). "Requirements for calcium and calmodulin in the calmodulin kinase activation cascade". J. Biol. Chem. 271 (10): 5617–22. doi:10.1074/jbc.271.10.5617. PMID 8621423.
Chatila T, Anderson KA, Ho N, Means AR (1996). "A unique phosphorylation-dependent mechanism for the activation of Ca²⁺/calmodulin-dependent protein kinase type IV/GR". J. Biol. Chem. 271 (35): 21542–8. doi:10.1074/jbc.271.35.21542. PMID 8702940.
Melander Gradin H, Marklund U, Larsson N, et al. (1997). "Regulation of microtubule dynamics by Ca²⁺/calmodulin-dependent kinase IV/Gr-dependent phosphorylation of oncoprotein 18". Mol. Cell. Biol. 17 (6): 3459–67. doi:10.1128/mcb.17.6.3459. PMC 232199. PMID 9154845.
Matsushita M, Nairn AC (1998). "Characterization of the mechanism of regulation of Ca²⁺/ calmodulin-dependent protein kinase I by calmodulin and by Ca²⁺/calmodulin-dependent protein kinase kinase". J. Biol. Chem. 273 (34): 21473–81. doi:10.1074/jbc.273.34.21473. PMID 9705275.
Anderson KA, Means RL, Huang QH, et al. (1998). "Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca²⁺/calmodulin-dependent protein kinase kinase beta". J. Biol. Chem. 273 (48): 31880–9. doi:10.1074/jbc.273.48.31880. PMID 9822657.
Hayashi Y, Nishio M, Naito Y, et al. (1999). "Regulation of neuronal nitric-oxide synthase by calmodulin kinases". J. Biol. Chem. 274 (29): 20597–602. doi:10.1074/jbc.274.29.20597. PMID 10400690.
Blaeser F, Ho N, Prywes R, Chatila TA (2000). "Ca²⁺-dependent gene expression mediated by MEF2 transcription factors". J. Biol. Chem. 275 (1): 197–209. doi:10.1074/jbc.275.1.197. PMID 10617605.
Moreno CS, Park S, Nelson K, et al. (2000). "WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A". J. Biol. Chem. 275 (8): 5257–63. doi:10.1074/jbc.275.8.5257. PMC 3505218. PMID 10681496.
Komeima K, Hayashi Y, Naito Y, Watanabe Y (2000). "Inhibition of neuronal nitric-oxide synthase by calcium/ calmodulin-dependent protein kinase IIalpha through Ser847 phosphorylation in NG108-15 neuronal cells". J. Biol. Chem. 275 (36): 28139–43. doi:10.1074/jbc.M003198200. PMID 10874031.
Wu JY, Ribar TJ, Cummings DE, et al. (2000). "Spermiogenesis and exchange of basic nuclear proteins are impaired in male germ cells lacking Camk4". Nat. Genet. 25 (4): 448–52. doi:10.1038/78153. PMID 10932193. S2CID 10803791.
Jang MK, Goo YH, Sohn YC, et al. (2001). "Ca²⁺/calmodulin-dependent protein kinase IV stimulates nuclear factor-kappa B transactivation via phosphorylation of the p65 subunit". J. Biol. Chem. 276 (23): 20005–10. doi:10.1074/jbc.M010211200. PMID 11274168.
Hsu LS, Chen GD, Lee LS, et al. (2001). "Human Ca²⁺/calmodulin-dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity". J. Biol. Chem. 276 (33): 31113–23. doi:10.1074/jbc.M011720200. PMID 11395482.
Zhao X, Ito A, Kane CD, et al. (2001). "The modular nature of histone deacetylase HDAC4 confers phosphorylation-dependent intracellular trafficking". J. Biol. Chem. 276 (37): 35042–8. doi:10.1074/jbc.M105086200. PMID 11470791.
Ainhoa Bilbaoa; Jan Rodriguez Parkitnab; David Engblomb; Stéphanie Perreau-Lenza; Carles Sanchis-Seguraa; Miriam Schneidera; Witold Konopkab; Magdalena Westphalb; Gerome Breenc; Sylvane Desrivieresc; Matthias Klugmannd; Camila Guindalinie; Homero Valladag; Ronaldo Laranjeirae; Fernando Rodriguez de Fonsecah; Gunter Schumannc; Günther Schützb & Rainer Spanagela (2008). "Loss of the Ca²⁺/calmodulin-dependent protein kinase type IV in dopaminoceptive neurons enhances behavioral effects of cocaine". Proceedings of the National Academy of Sciences of the United States of America. 105 (45). PNAS: 17549–54. Bibcode:2008PNAS..10517549B. doi:10.1073/pnas.0803959105. PMC 2582267. PMID 19001277.
Feliciano DM, Edelman AM (2009). "Repression of Ca²⁺/calmodulin-dependent protein kinase IV signaling accelerates retinoic acid-induced differentiation of human neuroblastoma cells". J. Biol. Chem. 284 (39): 26466–81. doi:10.1074/jbc.M109.027680. PMC 2785335. PMID 19633294.

External links

Human CAMK4 genome location and CAMK4 gene details page in the UCSC Genome Browser.

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000152495 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038128 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2536634-5] Sikela JM, Law ML, Kao FT, Hartz JA, Wei Q, Hahn WE (Mar 1989). "Chromosomal localization of the human gene for brain Ca²⁺/calmodulin-dependent protein kinase type IV". Genomics. 4 (1): 21–7. doi:10.1016/0888-7543(89)90309-1. PMID 2536634.

[entrez-6] "Entrez Gene: CAMK4 calcium/calmodulin-dependent protein kinase IV".

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CAMK4

References

Further reading

External links