Mitogen-activated protein kinase 4 is an enzyme that in humans is encoded by the MAPK4gene.[5][6]
Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus where it phosphorylates nuclear targets.[6]
The Arabidopsis MAPK4 is important in signalling [7]
Mechanistically, MAPK4 directly bound and activated AKT by phosphorylation of the activation loop at threonine 308. It also activated mTORC2 to phosphorylate AKT at serine 473 for full activation. MAPK4 overexpression induced oncogenic outcomes, including transforming prostate epithelial cells into anchorage-independent growth, and MAPK4 knockdown inhibited cancer cell proliferation, anchorage-independent growth, and xenograft growth.[8]
Robinson MJ, Cobb MH (April 1997). "Mitogen-activated protein kinase pathways". Current Opinion in Cell Biology. 9 (2): 180–6. doi:10.1016/S0955-0674(97)80061-0. PMID9069255.
Gonzalez FA, Raden DL, Rigby MR, Davis RJ (June 1992). "Heterogeneous expression of four MAP kinase isoforms in human tissues". FEBS Letters. 304 (2–3): 170–8. doi:10.1016/0014-5793(92)80612-K. PMID1319925. S2CID42548392.
Sun M, Wei Y, Yao L, Xie J, Chen X, Wang H, et al. (February 2006). "Identification of extracellular signal-regulated kinase 3 as a new interaction partner of cyclin D3". Biochemical and Biophysical Research Communications. 340 (1): 209–14. doi:10.1016/j.bbrc.2005.12.003. PMID16360641.
