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CDK11B
Identifiers
Aliases	CDK11B, CDC2L1, CDK11, CDK11-p110, CDK11-p46, CDK11-p58, CLK-1, PITSLREA, PK58, p58, p58CDC2L1, p58CLK-1, cyclin-dependent kinase 11B, cyclin dependent kinase 11B
External IDs	OMIM: 176873; MGI: 88353; HomoloGene: 137644; GeneCards: CDK11B; OMA:CDK11B - orthologs
EC number	2.7.11.22
Gene location (Human)
Chr.	Chromosome 1 (human)
End	1,659,012 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	155,649,938 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; gastrocnemius muscle; ; gastric mucosa; ; left testis; ; muscle layer of sigmoid colon; ; right testis; ; granulocyte; ; mucosa of transverse colon; ; muscle of thigh; ; right lung;
	Top expressed in
	granulocyte; ; tail of embryo; ; neural layer of retina; ; saccule; ; genital tubercle; ; otic placode; ; ventricular zone; ; otic vesicle; ; epiblast; ; body of femur;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; kinase activity; nucleotide binding; transferase activity; protein serine/threonine kinase activity; ATP binding; protein kinase activity; cyclin-dependent protein serine/threonine kinase activity; RNA binding;
Cellular component	nucleus; cytoplasm;
Biological process	regulation of transcription, DNA-templated; phosphorylation; cell cycle; regulation of cell growth; cell population proliferation; regulation of mRNA processing; apoptotic process; protein phosphorylation; regulation of mitotic cell cycle; mitotic cell cycle; regulation of cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	984
	12537
	ENSG00000248333
	ENSMUSG00000029062
	P21127
	P24788
NM_001291345; NM_001787; NM_033486; NM_033487; NM_033488;
	NM_033489; NM_033490; NM_033492; NM_033493
	NM_007661; NM_001347308; NM_001355567; NM_001355568; NM_001355569
NP_001278274; NP_001778; NP_277021; NP_277022; NP_277024;
	NP_277025
	NP_001334237; NP_031687; NP_001342496; NP_001342497; NP_001342498
	Wikidata
View/Edit Human	View/Edit Mouse

PITSLRE serine/threonine-protein kinase CDC2L1 is an enzyme that in humans is encoded by the CDK11B gene.^[5]^[6]^[7]

This gene encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be essential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L2, a nearly identical gene in the same chromosomal region. The gene loci including this gene, CDC2L2, as well as metalloprotease MMP21/22, consist of two identical, tandemly linked genomic regions which are thought to be a part of the larger region that has been duplicated. This gene and CDC2L2 were shown to be deleted or altered frequently in neuroblastoma with amplified MYCN genes. The protein kinase encoded by this gene could be cleaved by caspases and was demonstrated to play roles in cell apoptosis. Several alternatively spliced variants of this gene have been reported.^[7]

Interactions

CDC2L1 has been shown to interact with Cyclin D3.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000248333 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029062 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Eipers PG, Barnoski BL, Han J, Carroll AJ, Kidd VJ (Mar 1992). "Localization of the expressed human p58 protein kinase chromosomal gene to chromosome 1p36 and a highly related sequence to chromosome 15". Genomics. 11 (3): 621–9. doi:10.1016/0888-7543(91)90069-Q. PMID 1774066.
^ Mikolajczyk M, Shi J, Vaillancourt RR, Sachs NA, Nelson M (Sep 2003). "The cyclin-dependent kinase 11(p46) isoform interacts with RanBPM". Biochem. Biophys. Res. Commun. 310 (1): 14–8. doi:10.1016/j.bbrc.2003.08.116. PMID 14511641.
^ ^a ^b "Entrez Gene: CDC2L1 cell division cycle 2-like 1 (PITSLRE proteins)".
^ Zhang, Songwen; Cai Mingmei; Zhang Si; Xu Songli; Chen She; Chen Xiaoning; Chen Chun; Gu Jianxin (Sep 2002). "Interaction of p58(PITSLRE), a G2/M-specific protein kinase, with cyclin D3". J. Biol. Chem. 277 (38): 35314–22. doi:10.1074/jbc.M202179200. ISSN 0021-9258. PMID 12082095.